Package: CONSTANd Type: Package Title: Data normalization by matrix raking Version: 1.20.0 Date: 2020-10-30 Authors@R: c(person("Joris", "Van Houtven", email="joris.vanhoutven@uhasselt.be", role=c("aut","trl")), person("Geert Jan", "Bex", email="geertjan.bex@uhasselt.be", role=c("trl")), person("Dirk", "Valkenborg", email="dirk.valkenborg@uhasselt.be", role=c("aut", "cre"))) Description: Normalizes a data matrix `data` by raking (using the RAS method by Bacharach, see references) the Nrows by Ncols matrix such that the row means and column means equal 1. The result is a normalized data matrix `K=RAS`, a product of row mulipliers `R` and column multipliers `S` with the original matrix `A`. Missing information needs to be presented as `NA` values and not as zero values, because CONSTANd is able to ignore missing values when calculating the mean. Using CONSTANd normalization allows for the direct comparison of values between samples within the same and even across different CONSTANd-normalized data matrices. License: file LICENSE Encoding: UTF-8 biocViews: MassSpectrometry, Cheminformatics, Normalization, Preprocessing, DifferentialExpression, Genetics, Transcriptomics, Proteomics NeedsCompilation: no Depends: R (>= 4.1) Suggests: BiocStyle, knitr, rmarkdown, tidyr, ggplot2, gridExtra, magick, Cairo, limma SystemRequirements: BugReports: https://github.com/PDiracDelta/CONSTANd/issues URL: qcquan.net/constand VignetteBuilder: knitr Repository: Bioconductor 3.23 Date/Publication: 2026-04-28 12:54:46 UTC RemoteUrl: https://github.com/bioc/CONSTANd RemoteRef: RELEASE_3_23 RemoteSha: 400ef7bcace0eb05560481b179f780fd60156326 Packaged: 2026-07-05 00:13:48 UTC; root Author: Joris Van Houtven [aut, trl], Geert Jan Bex [trl], Dirk Valkenborg [aut, cre] Maintainer: Dirk Valkenborg