Package: DCATS Type: Package Title: Differential Composition Analysis Transformed by a Similarity matrix Version: 1.10.0 Authors@R: c( person("Xinyi", "Lin", , "linxy29@connect.hku.hk", role = c("aut", "cre"), comment = c(ORCID = "0000-0002-7780-2461")), person("Chuen", "Chau", email = "hadley@posit.co", role = "aut"), person("Yuanhua", "Huang", email = "jenny@posit.co", role = "aut"), person("Joshua W.K. Ho", role = "aut")) Description: Methods to detect the differential composition abundances between conditions in singel-cell RNA-seq experiments, with or without replicates. It aims to correct bias introduced by missclaisification and enable controlling of confounding covariates. To avoid the influence of proportion change from big cell types, DCATS can use either total cell number or specific reference group as normalization term. Depends: R (>= 4.1.0), stats License: MIT + file LICENSE Imports: MCMCpack, matrixStats, robustbase, aod, e1071 Suggests: testthat (>= 3.0.0), knitr, Seurat, SeuratObject, tidyverse, rmarkdown, BiocStyle VignetteBuilder: knitr RoxygenNote: 7.2.3 biocViews: SingleCell, Normalization Encoding: UTF-8 Config/testthat/edition: 3 Repository: Bioconductor 3.23 Date/Publication: 2026-04-28 13:00:56 UTC RemoteUrl: https://github.com/bioc/DCATS RemoteRef: RELEASE_3_23 RemoteSha: 80b8b0addfe4a84eb4bc14bbcdb7850fcad2e9c7 NeedsCompilation: no Packaged: 2026-07-02 09:27:11 UTC; root Author: Xinyi Lin [aut, cre] (ORCID: ), Chuen Chau [aut], Yuanhua Huang [aut], Joshua W.K. Ho [aut] Maintainer: Xinyi Lin