Macarron User Manual

Abstract

Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.

If you have questions, please direct it to: Macarron Forum

Installation

Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:

if(!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("Macarron")

Running Macarron

Macarron can be run from the command line or as an R function. Both methods require the same arguments, have the same options, and use the same default settings. The package includes the wrapper Macarron() as well as functions which perform different steps in the Macarron framework.

Input CSV files

Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.

  1. Metabolic features abundances
    • Must contain features in rows and samples in columns.
    • First column must identify features.
  2. Metabolic features annotations
    • Must contain features in rows and annotations in columns.
    • First column must identify features.
    • Second column must contain either HMDB ID or PubChem Compound Identifier (CID).
    • Third column must contain the name of the metabolite.
    • Fourth column must contain a continuous chemical property such as m/z or RT or shift/ppm.
    • Other annotations such as RT, m/z or other identifiers can be listed column 4 onward.
  3. Sample metadata
    • Must contain samples in rows and metadata in columns.
    • First column must identify samples.
    • Second column must contain categorical metadata relevant to prioritization such as phenotypes, exposures or environments.
  4. Chemical taxonomy
    • First column must contain the HMDB ID or PubChem CID. IDs must be consistent between annotation and taxonomy files.
    • Second and third columns must contain chemical subclass and class of the respective metabolite.

If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID (see Advanced Topics).

Output Files

By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv. Another file, prioritized_metabolites_characterizable.csv is a subset of prioritized_metabolites_all.csv and only contains metabolic features which covary with at least one annotated metabolite. The columns in these output files are:

  • Feature_index: Lists the identifier of the metabolic feature found in column 1 of abundance and annotation files.
  • HMDB_ID (or PubChem ID): Public database identifier from column 2 of annotation file (column 1 of annotation dataframe).
  • Metabolite name: From column 2 of annotation dataframe.
  • mz: The continuous numerical chemical property from column 3 of the annotation dataframe.
  • Priority_score: 1 indicates most prioritized. It is the percentile from the meta-rank of AVA, q-value and effect size.
  • Status: Direction of perturbation (differential abundance) in the phenotype (or environment) of interest compared to reference phenotype.
  • Module: ID of the covariance module a metabolic feature is a member of. Module = 0 indicates a singleton i.e., a metabolic feature that is not assigned to any module.
  • Anchor (of a module): Metabolic feature that has the highest abundance in any phenotype.
  • Related_classes: Chemical taxonomy of the annotated features that covary with a metabolic feature.
  • Covaries_with_standard: 1 (yes) and 0 (no). Column specifies if the metabolic feature covaries with at least one annotated (standard) metabolite.
  • AVA: Abundance versus anchor which is a ratio of the highest abundance (in any phenotype) of a metabolic feature and highest abundance of the covarying anchor. Naturally, the AVA of an anchor metabolite is 1.
  • qvalue: Estimated from multivariate linear model using Maaslin2.
  • effect_size
  • Remaining columns from the annotation dataframe are appended.

Run a demo in R

Using CSV files as inputs

Example (demo) input files can be found under inst/extdata folder of the Macarron source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv, demo_annotations.csv, demo_metadata.csv, and demo_taxonomy.csv.

library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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## Loading required package: GenomicRanges
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prism_abundances <- system.file(
    'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
    'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
    'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
                                        input_annotations = prism_annotations,
                                        input_metadata = prism_metadata,
                                        input_taxonomy = mets_taxonomy)
## 2026-10-08 09:59:53.597563 INFO::Creating output folder.
## 2026-10-08 09:59:53.602546 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2026-10-08 09:59:53.623809 INFO::Summarized Experiment created.
## 2026-10-08 09:59:53.624405 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2026-10-08 09:59:55.688925 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2026-10-08 09:59:55.689811 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
## 2026-10-08 09:59:56.455348 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2026-10-08 09:59:57.154769 INFO::Writing function arguments to log file
## 2026-10-08 09:59:57.156808 INFO::Verifying options selected are valid
## 2026-10-08 09:59:57.171815 INFO::Determining format of input files
## 2026-10-08 09:59:57.172346 INFO::Input format is data samples as columns and metadata samples as rows
## 2026-10-08 09:59:57.179516 INFO::Formula for fixed effects: expr ~  diagnosis + age + antibiotics
## 2026-10-08 09:59:57.180137 INFO::Filter data based on min abundance and min prevalence
## 2026-10-08 09:59:57.180408 INFO::Total samples in data: 102
## 2026-10-08 09:59:57.180623 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2026-10-08 09:59:57.185789 INFO::Total filtered features: 0
## 2026-10-08 09:59:57.186131 INFO::Filtered feature names from abundance and prevalence filtering:
## 2026-10-08 09:59:57.195024 INFO::Total filtered features with variance filtering: 10
## 2026-10-08 09:59:57.195412 INFO::Filtered feature names from variance filtering: F1, F59, F74, F416, F577, F629, F672, F744, F754, F846
## 2026-10-08 09:59:57.195643 INFO::Running selected normalization method: NONE
## 2026-10-08 09:59:57.195885 INFO::Applying z-score to standardize continuous metadata
## 2026-10-08 09:59:57.204906 INFO::Running selected transform method: NONE
## 2026-10-08 09:59:57.205253 INFO::Running selected analysis method: LM
## 2026-10-08 09:59:57.207541 INFO::Fitting model to feature number 1, F2
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## 2026-10-08 09:59:57.429552 INFO::Fitting model to feature number 158, F167
## 2026-10-08 09:59:57.430725 INFO::Fitting model to feature number 159, F168
## 2026-10-08 09:59:57.4319 INFO::Fitting model to feature number 160, F169
## 2026-10-08 09:59:57.433081 INFO::Fitting model to feature number 161, F170
## 2026-10-08 09:59:57.434285 INFO::Fitting model to feature number 162, F171
## 2026-10-08 09:59:57.435492 INFO::Fitting model to feature number 163, F172
## 2026-10-08 09:59:57.436733 INFO::Fitting model to feature number 164, F173
## 2026-10-08 09:59:57.43795 INFO::Fitting model to feature number 165, F174
## 2026-10-08 09:59:57.43919 INFO::Fitting model to feature number 166, F175
## 2026-10-08 09:59:57.440423 INFO::Fitting model to feature number 167, F176
## 2026-10-08 09:59:57.441644 INFO::Fitting model to feature number 168, F177
## 2026-10-08 09:59:57.442849 INFO::Fitting model to feature number 169, F178
## 2026-10-08 09:59:57.444118 INFO::Fitting model to feature number 170, F179
## 2026-10-08 09:59:57.445333 INFO::Fitting model to feature number 171, F180
## 2026-10-08 09:59:57.446526 INFO::Fitting model to feature number 172, F181
## 2026-10-08 09:59:57.447737 INFO::Fitting model to feature number 173, F182
## 2026-10-08 09:59:57.44893 INFO::Fitting model to feature number 174, F183
## 2026-10-08 09:59:57.450152 INFO::Fitting model to feature number 175, F184
## 2026-10-08 09:59:57.451361 INFO::Fitting model to feature number 176, F185
## 2026-10-08 09:59:57.452589 INFO::Fitting model to feature number 177, F186
## 2026-10-08 09:59:57.453931 INFO::Fitting model to feature number 178, F187
## 2026-10-08 09:59:57.455977 INFO::Fitting model to feature number 179, F188
## 2026-10-08 09:59:57.457531 INFO::Fitting model to feature number 180, F189
## 2026-10-08 09:59:57.458788 INFO::Fitting model to feature number 181, F190
## 2026-10-08 09:59:57.460039 INFO::Fitting model to feature number 182, F191
## 2026-10-08 09:59:57.461287 INFO::Fitting model to feature number 183, F192
## 2026-10-08 09:59:57.46253 INFO::Fitting model to feature number 184, F193
## 2026-10-08 09:59:57.463874 INFO::Fitting model to feature number 185, F194
## 2026-10-08 09:59:57.465256 INFO::Fitting model to feature number 186, F195
## 2026-10-08 09:59:57.466472 INFO::Fitting model to feature number 187, F196
## 2026-10-08 09:59:57.467688 INFO::Fitting model to feature number 188, F197
## 2026-10-08 09:59:57.468935 INFO::Fitting model to feature number 189, F198
## 2026-10-08 09:59:57.470186 INFO::Fitting model to feature number 190, F199
## 2026-10-08 09:59:57.471455 INFO::Fitting model to feature number 191, F200
## 2026-10-08 09:59:57.472703 INFO::Fitting model to feature number 192, F201
## 2026-10-08 09:59:57.474009 INFO::Fitting model to feature number 193, F202
## 2026-10-08 09:59:57.475268 INFO::Fitting model to feature number 194, F203
## 2026-10-08 09:59:57.476549 INFO::Fitting model to feature number 195, F204
## 2026-10-08 09:59:57.477803 INFO::Fitting model to feature number 196, F206
## 2026-10-08 09:59:57.479209 INFO::Fitting model to feature number 197, F207
## 2026-10-08 09:59:57.480434 INFO::Fitting model to feature number 198, F208
## 2026-10-08 09:59:57.481684 INFO::Fitting model to feature number 199, F209
## 2026-10-08 09:59:57.482919 INFO::Fitting model to feature number 200, F210
## 2026-10-08 09:59:57.484143 INFO::Fitting model to feature number 201, F211
## 2026-10-08 09:59:57.485373 INFO::Fitting model to feature number 202, F212
## 2026-10-08 09:59:57.486598 INFO::Fitting model to feature number 203, F213
## 2026-10-08 09:59:57.487817 INFO::Fitting model to feature number 204, F214
## 2026-10-08 09:59:57.489037 INFO::Fitting model to feature number 205, F215
## 2026-10-08 09:59:57.490256 INFO::Fitting model to feature number 206, F216
## 2026-10-08 09:59:57.491471 INFO::Fitting model to feature number 207, F217
## 2026-10-08 09:59:57.492675 INFO::Fitting model to feature number 208, F218
## 2026-10-08 09:59:57.493876 INFO::Fitting model to feature number 209, F219
## 2026-10-08 09:59:57.495106 INFO::Fitting model to feature number 210, F220
## 2026-10-08 09:59:57.496348 INFO::Fitting model to feature number 211, F221
## 2026-10-08 09:59:57.497556 INFO::Fitting model to feature number 212, F222
## 2026-10-08 09:59:57.498765 INFO::Fitting model to feature number 213, F223
## 2026-10-08 09:59:57.499968 INFO::Fitting model to feature number 214, F224
## 2026-10-08 09:59:57.501174 INFO::Fitting model to feature number 215, F225
## 2026-10-08 09:59:57.502392 INFO::Fitting model to feature number 216, F226
## 2026-10-08 09:59:57.503634 INFO::Fitting model to feature number 217, F227
## 2026-10-08 09:59:57.504884 INFO::Fitting model to feature number 218, F228
## 2026-10-08 09:59:57.506094 INFO::Fitting model to feature number 219, F229
## 2026-10-08 09:59:57.507303 INFO::Fitting model to feature number 220, F230
## 2026-10-08 09:59:57.508521 INFO::Fitting model to feature number 221, F231
## 2026-10-08 09:59:57.509728 INFO::Fitting model to feature number 222, F232
## 2026-10-08 09:59:57.51092 INFO::Fitting model to feature number 223, F233
## 2026-10-08 09:59:57.512131 INFO::Fitting model to feature number 224, F234
## 2026-10-08 09:59:57.513331 INFO::Fitting model to feature number 225, F235
## 2026-10-08 09:59:57.514515 INFO::Fitting model to feature number 226, F236
## 2026-10-08 09:59:57.515693 INFO::Fitting model to feature number 227, F237
## 2026-10-08 09:59:57.516864 INFO::Fitting model to feature number 228, F238
## 2026-10-08 09:59:57.518044 INFO::Fitting model to feature number 229, F239
## 2026-10-08 09:59:57.519226 INFO::Fitting model to feature number 230, F240
## 2026-10-08 09:59:57.520418 INFO::Fitting model to feature number 231, F241
## 2026-10-08 09:59:57.521629 INFO::Fitting model to feature number 232, F242
## 2026-10-08 09:59:57.522851 INFO::Fitting model to feature number 233, F243
## 2026-10-08 09:59:57.524098 INFO::Fitting model to feature number 234, F244
## 2026-10-08 09:59:57.525334 INFO::Fitting model to feature number 235, F245
## 2026-10-08 09:59:57.526504 INFO::Fitting model to feature number 236, F246
## 2026-10-08 09:59:57.52768 INFO::Fitting model to feature number 237, F247
## 2026-10-08 09:59:57.528881 INFO::Fitting model to feature number 238, F248
## 2026-10-08 09:59:57.530089 INFO::Fitting model to feature number 239, F249
## 2026-10-08 09:59:57.531284 INFO::Fitting model to feature number 240, F250
## 2026-10-08 09:59:57.532495 INFO::Fitting model to feature number 241, F252
## 2026-10-08 09:59:57.533701 INFO::Fitting model to feature number 242, F253
## 2026-10-08 09:59:57.534896 INFO::Fitting model to feature number 243, F254
## 2026-10-08 09:59:57.536099 INFO::Fitting model to feature number 244, F255
## 2026-10-08 09:59:57.537326 INFO::Fitting model to feature number 245, F256
## 2026-10-08 09:59:57.538509 INFO::Fitting model to feature number 246, F257
## 2026-10-08 09:59:57.539684 INFO::Fitting model to feature number 247, F259
## 2026-10-08 09:59:57.540851 INFO::Fitting model to feature number 248, F260
## 2026-10-08 09:59:57.542008 INFO::Fitting model to feature number 249, F261
## 2026-10-08 09:59:57.543179 INFO::Fitting model to feature number 250, F262
## 2026-10-08 09:59:57.544376 INFO::Fitting model to feature number 251, F263
## 2026-10-08 09:59:57.54554 INFO::Fitting model to feature number 252, F264
## 2026-10-08 09:59:57.546702 INFO::Fitting model to feature number 253, F265
## 2026-10-08 09:59:57.547873 INFO::Fitting model to feature number 254, F266
## 2026-10-08 09:59:57.549037 INFO::Fitting model to feature number 255, F267
## 2026-10-08 09:59:57.55022 INFO::Fitting model to feature number 256, F269
## 2026-10-08 09:59:57.551393 INFO::Fitting model to feature number 257, F270
## 2026-10-08 09:59:57.552561 INFO::Fitting model to feature number 258, F271
## 2026-10-08 09:59:57.553757 INFO::Fitting model to feature number 259, F272
## 2026-10-08 09:59:57.554941 INFO::Fitting model to feature number 260, F273
## 2026-10-08 09:59:57.556142 INFO::Fitting model to feature number 261, F274
## 2026-10-08 09:59:57.55739 INFO::Fitting model to feature number 262, F276
## 2026-10-08 09:59:57.558572 INFO::Fitting model to feature number 263, F277
## 2026-10-08 09:59:57.559752 INFO::Fitting model to feature number 264, F278
## 2026-10-08 09:59:57.560925 INFO::Fitting model to feature number 265, F279
## 2026-10-08 09:59:57.562101 INFO::Fitting model to feature number 266, F280
## 2026-10-08 09:59:57.56329 INFO::Fitting model to feature number 267, F281
## 2026-10-08 09:59:57.564466 INFO::Fitting model to feature number 268, F282
## 2026-10-08 09:59:57.565645 INFO::Fitting model to feature number 269, F283
## 2026-10-08 09:59:57.566807 INFO::Fitting model to feature number 270, F284
## 2026-10-08 09:59:57.567957 INFO::Fitting model to feature number 271, F285
## 2026-10-08 09:59:57.569129 INFO::Fitting model to feature number 272, F286
## 2026-10-08 09:59:57.570343 INFO::Fitting model to feature number 273, F287
## 2026-10-08 09:59:57.571507 INFO::Fitting model to feature number 274, F288
## 2026-10-08 09:59:57.572681 INFO::Fitting model to feature number 275, F289
## 2026-10-08 09:59:57.573858 INFO::Fitting model to feature number 276, F290
## 2026-10-08 09:59:57.575019 INFO::Fitting model to feature number 277, F292
## 2026-10-08 09:59:57.57618 INFO::Fitting model to feature number 278, F293
## 2026-10-08 09:59:57.57736 INFO::Fitting model to feature number 279, F294
## 2026-10-08 09:59:57.57853 INFO::Fitting model to feature number 280, F295
## 2026-10-08 09:59:57.579706 INFO::Fitting model to feature number 281, F296
## 2026-10-08 09:59:57.580873 INFO::Fitting model to feature number 282, F297
## 2026-10-08 09:59:57.582041 INFO::Fitting model to feature number 283, F298
## 2026-10-08 09:59:57.583212 INFO::Fitting model to feature number 284, F299
## 2026-10-08 09:59:57.584382 INFO::Fitting model to feature number 285, F300
## 2026-10-08 09:59:57.585568 INFO::Fitting model to feature number 286, F301
## 2026-10-08 09:59:57.586763 INFO::Fitting model to feature number 287, F302
## 2026-10-08 09:59:57.587935 INFO::Fitting model to feature number 288, F303
## 2026-10-08 09:59:57.589103 INFO::Fitting model to feature number 289, F304
## 2026-10-08 09:59:57.590304 INFO::Fitting model to feature number 290, F305
## 2026-10-08 09:59:57.591532 INFO::Fitting model to feature number 291, F306
## 2026-10-08 09:59:57.592683 INFO::Fitting model to feature number 292, F307
## 2026-10-08 09:59:57.593847 INFO::Fitting model to feature number 293, F308
## 2026-10-08 09:59:57.595002 INFO::Fitting model to feature number 294, F309
## 2026-10-08 09:59:57.596158 INFO::Fitting model to feature number 295, F310
## 2026-10-08 09:59:57.59733 INFO::Fitting model to feature number 296, F311
## 2026-10-08 09:59:57.598485 INFO::Fitting model to feature number 297, F312
## 2026-10-08 09:59:57.599647 INFO::Fitting model to feature number 298, F313
## 2026-10-08 09:59:57.600828 INFO::Fitting model to feature number 299, F315
## 2026-10-08 09:59:57.60199 INFO::Fitting model to feature number 300, F316
## 2026-10-08 09:59:57.603194 INFO::Fitting model to feature number 301, F317
## 2026-10-08 09:59:57.604398 INFO::Fitting model to feature number 302, F318
## 2026-10-08 09:59:57.605626 INFO::Fitting model to feature number 303, F319
## 2026-10-08 09:59:57.606825 INFO::Fitting model to feature number 304, F320
## 2026-10-08 09:59:57.608023 INFO::Fitting model to feature number 305, F321
## 2026-10-08 09:59:57.609221 INFO::Fitting model to feature number 306, F322
## 2026-10-08 09:59:57.610429 INFO::Fitting model to feature number 307, F323
## 2026-10-08 09:59:57.611613 INFO::Fitting model to feature number 308, F324
## 2026-10-08 09:59:57.612786 INFO::Fitting model to feature number 309, F325
## 2026-10-08 09:59:57.61395 INFO::Fitting model to feature number 310, F326
## 2026-10-08 09:59:57.615161 INFO::Fitting model to feature number 311, F327
## 2026-10-08 09:59:57.616412 INFO::Fitting model to feature number 312, F328
## 2026-10-08 09:59:57.617667 INFO::Fitting model to feature number 313, F329
## 2026-10-08 09:59:57.618973 INFO::Fitting model to feature number 314, F330
## 2026-10-08 09:59:57.620308 INFO::Fitting model to feature number 315, F331
## 2026-10-08 09:59:57.621579 INFO::Fitting model to feature number 316, F332
## 2026-10-08 09:59:57.62285 INFO::Fitting model to feature number 317, F333
## 2026-10-08 09:59:57.624103 INFO::Fitting model to feature number 318, F334
## 2026-10-08 09:59:57.625381 INFO::Fitting model to feature number 319, F335
## 2026-10-08 09:59:57.626666 INFO::Fitting model to feature number 320, F336
## 2026-10-08 09:59:57.627977 INFO::Fitting model to feature number 321, F337
## 2026-10-08 09:59:57.629287 INFO::Fitting model to feature number 322, F338
## 2026-10-08 09:59:57.630543 INFO::Fitting model to feature number 323, F339
## 2026-10-08 09:59:57.63179 INFO::Fitting model to feature number 324, F340
## 2026-10-08 09:59:57.633053 INFO::Fitting model to feature number 325, F342
## 2026-10-08 09:59:57.634325 INFO::Fitting model to feature number 326, F343
## 2026-10-08 09:59:57.635636 INFO::Fitting model to feature number 327, F344
## 2026-10-08 09:59:57.636923 INFO::Fitting model to feature number 328, F345
## 2026-10-08 09:59:57.638216 INFO::Fitting model to feature number 329, F346
## 2026-10-08 09:59:57.650539 INFO::Fitting model to feature number 330, F347
## 2026-10-08 09:59:57.653264 INFO::Fitting model to feature number 331, F348
## 2026-10-08 09:59:57.654929 INFO::Fitting model to feature number 332, F350
## 2026-10-08 09:59:57.656474 INFO::Fitting model to feature number 333, F351
## 2026-10-08 09:59:57.657899 INFO::Fitting model to feature number 334, F352
## 2026-10-08 09:59:57.659271 INFO::Fitting model to feature number 335, F353
## 2026-10-08 09:59:57.660641 INFO::Fitting model to feature number 336, F355
## 2026-10-08 09:59:57.661991 INFO::Fitting model to feature number 337, F356
## 2026-10-08 09:59:57.663326 INFO::Fitting model to feature number 338, F357
## 2026-10-08 09:59:57.664596 INFO::Fitting model to feature number 339, F358
## 2026-10-08 09:59:57.665879 INFO::Fitting model to feature number 340, F359
## 2026-10-08 09:59:57.667121 INFO::Fitting model to feature number 341, F360
## 2026-10-08 09:59:57.668366 INFO::Fitting model to feature number 342, F361
## 2026-10-08 09:59:57.669637 INFO::Fitting model to feature number 343, F362
## 2026-10-08 09:59:57.670907 INFO::Fitting model to feature number 344, F363
## 2026-10-08 09:59:57.672131 INFO::Fitting model to feature number 345, F364
## 2026-10-08 09:59:57.673365 INFO::Fitting model to feature number 346, F365
## 2026-10-08 09:59:57.674595 INFO::Fitting model to feature number 347, F366
## 2026-10-08 09:59:57.675832 INFO::Fitting model to feature number 348, F367
## 2026-10-08 09:59:57.677081 INFO::Fitting model to feature number 349, F368
## 2026-10-08 09:59:57.678359 INFO::Fitting model to feature number 350, F369
## 2026-10-08 09:59:57.679594 INFO::Fitting model to feature number 351, F370
## 2026-10-08 09:59:57.680983 INFO::Fitting model to feature number 352, F371
## 2026-10-08 09:59:57.682415 INFO::Fitting model to feature number 353, F372
## 2026-10-08 09:59:57.683711 INFO::Fitting model to feature number 354, F373
## 2026-10-08 09:59:57.685035 INFO::Fitting model to feature number 355, F374
## 2026-10-08 09:59:57.686345 INFO::Fitting model to feature number 356, F375
## 2026-10-08 09:59:57.687626 INFO::Fitting model to feature number 357, F376
## 2026-10-08 09:59:57.688868 INFO::Fitting model to feature number 358, F377
## 2026-10-08 09:59:57.690121 INFO::Fitting model to feature number 359, F378
## 2026-10-08 09:59:57.691494 INFO::Fitting model to feature number 360, F379
## 2026-10-08 09:59:57.693371 INFO::Fitting model to feature number 361, F380
## 2026-10-08 09:59:57.694659 INFO::Fitting model to feature number 362, F381
## 2026-10-08 09:59:57.695918 INFO::Fitting model to feature number 363, F382
## 2026-10-08 09:59:57.69723 INFO::Fitting model to feature number 364, F383
## 2026-10-08 09:59:57.698765 INFO::Fitting model to feature number 365, F384
## 2026-10-08 09:59:57.700464 INFO::Fitting model to feature number 366, F386
## 2026-10-08 09:59:57.701928 INFO::Fitting model to feature number 367, F387
## 2026-10-08 09:59:57.703178 INFO::Fitting model to feature number 368, F388
## 2026-10-08 09:59:57.704592 INFO::Fitting model to feature number 369, F389
## 2026-10-08 09:59:57.705871 INFO::Fitting model to feature number 370, F390
## 2026-10-08 09:59:57.707121 INFO::Fitting model to feature number 371, F391
## 2026-10-08 09:59:57.708407 INFO::Fitting model to feature number 372, F392
## 2026-10-08 09:59:57.709688 INFO::Fitting model to feature number 373, F393
## 2026-10-08 09:59:57.710981 INFO::Fitting model to feature number 374, F394
## 2026-10-08 09:59:57.712665 INFO::Fitting model to feature number 375, F395
## 2026-10-08 09:59:57.714209 INFO::Fitting model to feature number 376, F396
## 2026-10-08 09:59:57.715731 INFO::Fitting model to feature number 377, F397
## 2026-10-08 09:59:57.717014 INFO::Fitting model to feature number 378, F398
## 2026-10-08 09:59:57.718418 INFO::Fitting model to feature number 379, F399
## 2026-10-08 09:59:57.719711 INFO::Fitting model to feature number 380, F400
## 2026-10-08 09:59:57.721024 INFO::Fitting model to feature number 381, F401
## 2026-10-08 09:59:57.722355 INFO::Fitting model to feature number 382, F402
## 2026-10-08 09:59:57.723678 INFO::Fitting model to feature number 383, F403
## 2026-10-08 09:59:57.724961 INFO::Fitting model to feature number 384, F404
## 2026-10-08 09:59:57.726239 INFO::Fitting model to feature number 385, F406
## 2026-10-08 09:59:57.727525 INFO::Fitting model to feature number 386, F407
## 2026-10-08 09:59:57.728796 INFO::Fitting model to feature number 387, F408
## 2026-10-08 09:59:57.730067 INFO::Fitting model to feature number 388, F409
## 2026-10-08 09:59:57.7313 INFO::Fitting model to feature number 389, F410
## 2026-10-08 09:59:57.732533 INFO::Fitting model to feature number 390, F411
## 2026-10-08 09:59:57.733766 INFO::Fitting model to feature number 391, F412
## 2026-10-08 09:59:57.734999 INFO::Fitting model to feature number 392, F413
## 2026-10-08 09:59:57.736252 INFO::Fitting model to feature number 393, F414
## 2026-10-08 09:59:57.737494 INFO::Fitting model to feature number 394, F415
## 2026-10-08 09:59:57.738747 INFO::Fitting model to feature number 395, F417
## 2026-10-08 09:59:57.739972 INFO::Fitting model to feature number 396, F418
## 2026-10-08 09:59:57.74119 INFO::Fitting model to feature number 397, F419
## 2026-10-08 09:59:57.74242 INFO::Fitting model to feature number 398, F420
## 2026-10-08 09:59:57.743637 INFO::Fitting model to feature number 399, F421
## 2026-10-08 09:59:57.744857 INFO::Fitting model to feature number 400, F422
## 2026-10-08 09:59:57.746125 INFO::Fitting model to feature number 401, F423
## 2026-10-08 09:59:57.747401 INFO::Fitting model to feature number 402, F425
## 2026-10-08 09:59:57.74862 INFO::Fitting model to feature number 403, F426
## 2026-10-08 09:59:57.749832 INFO::Fitting model to feature number 404, F428
## 2026-10-08 09:59:57.751043 INFO::Fitting model to feature number 405, F429
## 2026-10-08 09:59:57.752279 INFO::Fitting model to feature number 406, F430
## 2026-10-08 09:59:57.753514 INFO::Fitting model to feature number 407, F431
## 2026-10-08 09:59:57.754742 INFO::Fitting model to feature number 408, F432
## 2026-10-08 09:59:57.755948 INFO::Fitting model to feature number 409, F433
## 2026-10-08 09:59:57.757158 INFO::Fitting model to feature number 410, F434
## 2026-10-08 09:59:57.758387 INFO::Fitting model to feature number 411, F435
## 2026-10-08 09:59:57.759573 INFO::Fitting model to feature number 412, F436
## 2026-10-08 09:59:57.760756 INFO::Fitting model to feature number 413, F437
## 2026-10-08 09:59:57.76195 INFO::Fitting model to feature number 414, F438
## 2026-10-08 09:59:57.763168 INFO::Fitting model to feature number 415, F439
## 2026-10-08 09:59:57.764443 INFO::Fitting model to feature number 416, F440
## 2026-10-08 09:59:57.765686 INFO::Fitting model to feature number 417, F441
## 2026-10-08 09:59:57.76694 INFO::Fitting model to feature number 418, F442
## 2026-10-08 09:59:57.768171 INFO::Fitting model to feature number 419, F443
## 2026-10-08 09:59:57.769419 INFO::Fitting model to feature number 420, F444
## 2026-10-08 09:59:57.770635 INFO::Fitting model to feature number 421, F445
## 2026-10-08 09:59:57.771862 INFO::Fitting model to feature number 422, F446
## 2026-10-08 09:59:57.773094 INFO::Fitting model to feature number 423, F447
## 2026-10-08 09:59:57.774315 INFO::Fitting model to feature number 424, F448
## 2026-10-08 09:59:57.775536 INFO::Fitting model to feature number 425, F449
## 2026-10-08 09:59:57.776778 INFO::Fitting model to feature number 426, F450
## 2026-10-08 09:59:57.777984 INFO::Fitting model to feature number 427, F451
## 2026-10-08 09:59:57.779252 INFO::Fitting model to feature number 428, F452
## 2026-10-08 09:59:57.780541 INFO::Fitting model to feature number 429, F454
## 2026-10-08 09:59:57.781823 INFO::Fitting model to feature number 430, F455
## 2026-10-08 09:59:57.783069 INFO::Fitting model to feature number 431, F456
## 2026-10-08 09:59:57.784361 INFO::Fitting model to feature number 432, F457
## 2026-10-08 09:59:57.785577 INFO::Fitting model to feature number 433, F458
## 2026-10-08 09:59:57.786822 INFO::Fitting model to feature number 434, F459
## 2026-10-08 09:59:57.788063 INFO::Fitting model to feature number 435, F461
## 2026-10-08 09:59:57.789275 INFO::Fitting model to feature number 436, F462
## 2026-10-08 09:59:57.790478 INFO::Fitting model to feature number 437, F463
## 2026-10-08 09:59:57.791677 INFO::Fitting model to feature number 438, F464
## 2026-10-08 09:59:57.792913 INFO::Fitting model to feature number 439, F465
## 2026-10-08 09:59:57.794124 INFO::Fitting model to feature number 440, F466
## 2026-10-08 09:59:57.795368 INFO::Fitting model to feature number 441, F467
## 2026-10-08 09:59:57.796604 INFO::Fitting model to feature number 442, F468
## 2026-10-08 09:59:57.797827 INFO::Fitting model to feature number 443, F469
## 2026-10-08 09:59:57.799038 INFO::Fitting model to feature number 444, F470
## 2026-10-08 09:59:57.800248 INFO::Fitting model to feature number 445, F471
## 2026-10-08 09:59:57.801436 INFO::Fitting model to feature number 446, F474
## 2026-10-08 09:59:57.80263 INFO::Fitting model to feature number 447, F475
## 2026-10-08 09:59:57.803844 INFO::Fitting model to feature number 448, F476
## 2026-10-08 09:59:57.805031 INFO::Fitting model to feature number 449, F477
## 2026-10-08 09:59:57.806246 INFO::Fitting model to feature number 450, F478
## 2026-10-08 09:59:57.807438 INFO::Fitting model to feature number 451, F479
## 2026-10-08 09:59:57.808626 INFO::Fitting model to feature number 452, F480
## 2026-10-08 09:59:57.809851 INFO::Fitting model to feature number 453, F481
## 2026-10-08 09:59:57.81107 INFO::Fitting model to feature number 454, F482
## 2026-10-08 09:59:57.812351 INFO::Fitting model to feature number 455, F483
## 2026-10-08 09:59:57.813581 INFO::Fitting model to feature number 456, F484
## 2026-10-08 09:59:57.814782 INFO::Fitting model to feature number 457, F485
## 2026-10-08 09:59:57.815985 INFO::Fitting model to feature number 458, F486
## 2026-10-08 09:59:57.817369 INFO::Fitting model to feature number 459, F487
## 2026-10-08 09:59:57.818553 INFO::Fitting model to feature number 460, F488
## 2026-10-08 09:59:57.81975 INFO::Fitting model to feature number 461, F489
## 2026-10-08 09:59:57.820927 INFO::Fitting model to feature number 462, F490
## 2026-10-08 09:59:57.822128 INFO::Fitting model to feature number 463, F491
## 2026-10-08 09:59:57.823332 INFO::Fitting model to feature number 464, F492
## 2026-10-08 09:59:57.824541 INFO::Fitting model to feature number 465, F493
## 2026-10-08 09:59:57.825731 INFO::Fitting model to feature number 466, F494
## 2026-10-08 09:59:57.82694 INFO::Fitting model to feature number 467, F495
## 2026-10-08 09:59:57.828162 INFO::Fitting model to feature number 468, F496
## 2026-10-08 09:59:57.829381 INFO::Fitting model to feature number 469, F497
## 2026-10-08 09:59:57.830596 INFO::Fitting model to feature number 470, F498
## 2026-10-08 09:59:57.831785 INFO::Fitting model to feature number 471, F499
## 2026-10-08 09:59:57.83299 INFO::Fitting model to feature number 472, F500
## 2026-10-08 09:59:57.834217 INFO::Fitting model to feature number 473, F501
## 2026-10-08 09:59:57.835417 INFO::Fitting model to feature number 474, F502
## 2026-10-08 09:59:57.836641 INFO::Fitting model to feature number 475, F503
## 2026-10-08 09:59:57.837852 INFO::Fitting model to feature number 476, F504
## 2026-10-08 09:59:57.83905 INFO::Fitting model to feature number 477, F505
## 2026-10-08 09:59:57.840255 INFO::Fitting model to feature number 478, F506
## 2026-10-08 09:59:57.841464 INFO::Fitting model to feature number 479, F507
## 2026-10-08 09:59:57.842653 INFO::Fitting model to feature number 480, F508
## 2026-10-08 09:59:57.843853 INFO::Fitting model to feature number 481, F509
## 2026-10-08 09:59:57.845032 INFO::Fitting model to feature number 482, F510
## 2026-10-08 09:59:57.846286 INFO::Fitting model to feature number 483, F511
## 2026-10-08 09:59:57.847532 INFO::Fitting model to feature number 484, F512
## 2026-10-08 09:59:57.848716 INFO::Fitting model to feature number 485, F513
## 2026-10-08 09:59:57.849898 INFO::Fitting model to feature number 486, F514
## 2026-10-08 09:59:57.851083 INFO::Fitting model to feature number 487, F515
## 2026-10-08 09:59:57.852292 INFO::Fitting model to feature number 488, F516
## 2026-10-08 09:59:57.853498 INFO::Fitting model to feature number 489, F517
## 2026-10-08 09:59:57.854684 INFO::Fitting model to feature number 490, F518
## 2026-10-08 09:59:57.855877 INFO::Fitting model to feature number 491, F519
## 2026-10-08 09:59:57.857079 INFO::Fitting model to feature number 492, F520
## 2026-10-08 09:59:57.858298 INFO::Fitting model to feature number 493, F521
## 2026-10-08 09:59:57.85949 INFO::Fitting model to feature number 494, F522
## 2026-10-08 09:59:57.860673 INFO::Fitting model to feature number 495, F523
## 2026-10-08 09:59:57.861864 INFO::Fitting model to feature number 496, F524
## 2026-10-08 09:59:57.863165 INFO::Fitting model to feature number 497, F525
## 2026-10-08 09:59:57.864391 INFO::Fitting model to feature number 498, F526
## 2026-10-08 09:59:57.865594 INFO::Fitting model to feature number 499, F527
## 2026-10-08 09:59:57.866786 INFO::Fitting model to feature number 500, F528
## 2026-10-08 09:59:57.868003 INFO::Fitting model to feature number 501, F529
## 2026-10-08 09:59:57.869229 INFO::Fitting model to feature number 502, F530
## 2026-10-08 09:59:57.870576 INFO::Fitting model to feature number 503, F531
## 2026-10-08 09:59:57.871939 INFO::Fitting model to feature number 504, F532
## 2026-10-08 09:59:57.873174 INFO::Fitting model to feature number 505, F533
## 2026-10-08 09:59:57.874374 INFO::Fitting model to feature number 506, F534
## 2026-10-08 09:59:57.87568 INFO::Fitting model to feature number 507, F535
## 2026-10-08 09:59:57.877268 INFO::Fitting model to feature number 508, F536
## 2026-10-08 09:59:57.87858 INFO::Fitting model to feature number 509, F537
## 2026-10-08 09:59:57.879834 INFO::Fitting model to feature number 510, F539
## 2026-10-08 09:59:57.88109 INFO::Fitting model to feature number 511, F540
## 2026-10-08 09:59:57.882569 INFO::Fitting model to feature number 512, F541
## 2026-10-08 09:59:57.883808 INFO::Fitting model to feature number 513, F543
## 2026-10-08 09:59:57.885032 INFO::Fitting model to feature number 514, F544
## 2026-10-08 09:59:57.886503 INFO::Fitting model to feature number 515, F545
## 2026-10-08 09:59:57.887761 INFO::Fitting model to feature number 516, F546
## 2026-10-08 09:59:57.889004 INFO::Fitting model to feature number 517, F547
## 2026-10-08 09:59:57.890229 INFO::Fitting model to feature number 518, F548
## 2026-10-08 09:59:57.891456 INFO::Fitting model to feature number 519, F549
## 2026-10-08 09:59:57.892974 INFO::Fitting model to feature number 520, F550
## 2026-10-08 09:59:57.894275 INFO::Fitting model to feature number 521, F551
## 2026-10-08 09:59:57.895581 INFO::Fitting model to feature number 522, F552
## 2026-10-08 09:59:57.896846 INFO::Fitting model to feature number 523, F553
## 2026-10-08 09:59:57.898097 INFO::Fitting model to feature number 524, F554
## 2026-10-08 09:59:57.899363 INFO::Fitting model to feature number 525, F555
## 2026-10-08 09:59:57.900613 INFO::Fitting model to feature number 526, F556
## 2026-10-08 09:59:57.90185 INFO::Fitting model to feature number 527, F557
## 2026-10-08 09:59:57.903121 INFO::Fitting model to feature number 528, F558
## 2026-10-08 09:59:57.904395 INFO::Fitting model to feature number 529, F559
## 2026-10-08 09:59:57.905652 INFO::Fitting model to feature number 530, F560
## 2026-10-08 09:59:57.906912 INFO::Fitting model to feature number 531, F561
## 2026-10-08 09:59:57.908195 INFO::Fitting model to feature number 532, F562
## 2026-10-08 09:59:57.909456 INFO::Fitting model to feature number 533, F563
## 2026-10-08 09:59:57.910706 INFO::Fitting model to feature number 534, F564
## 2026-10-08 09:59:57.911968 INFO::Fitting model to feature number 535, F566
## 2026-10-08 09:59:57.913239 INFO::Fitting model to feature number 536, F567
## 2026-10-08 09:59:57.914532 INFO::Fitting model to feature number 537, F568
## 2026-10-08 09:59:57.915812 INFO::Fitting model to feature number 538, F569
## 2026-10-08 09:59:57.917106 INFO::Fitting model to feature number 539, F570
## 2026-10-08 09:59:57.918377 INFO::Fitting model to feature number 540, F571
## 2026-10-08 09:59:57.919653 INFO::Fitting model to feature number 541, F572
## 2026-10-08 09:59:57.920904 INFO::Fitting model to feature number 542, F573
## 2026-10-08 09:59:57.92216 INFO::Fitting model to feature number 543, F574
## 2026-10-08 09:59:57.923419 INFO::Fitting model to feature number 544, F575
## 2026-10-08 09:59:57.924649 INFO::Fitting model to feature number 545, F576
## 2026-10-08 09:59:57.92586 INFO::Fitting model to feature number 546, F578
## 2026-10-08 09:59:57.927099 INFO::Fitting model to feature number 547, F579
## 2026-10-08 09:59:57.928332 INFO::Fitting model to feature number 548, F580
## 2026-10-08 09:59:57.929534 INFO::Fitting model to feature number 549, F581
## 2026-10-08 09:59:57.930762 INFO::Fitting model to feature number 550, F582
## 2026-10-08 09:59:57.931975 INFO::Fitting model to feature number 551, F583
## 2026-10-08 09:59:57.933183 INFO::Fitting model to feature number 552, F584
## 2026-10-08 09:59:57.934427 INFO::Fitting model to feature number 553, F585
## 2026-10-08 09:59:57.935648 INFO::Fitting model to feature number 554, F586
## 2026-10-08 09:59:57.93687 INFO::Fitting model to feature number 555, F587
## 2026-10-08 09:59:57.938082 INFO::Fitting model to feature number 556, F588
## 2026-10-08 09:59:57.93931 INFO::Fitting model to feature number 557, F589
## 2026-10-08 09:59:57.940518 INFO::Fitting model to feature number 558, F590
## 2026-10-08 09:59:57.941733 INFO::Fitting model to feature number 559, F591
## 2026-10-08 09:59:57.942955 INFO::Fitting model to feature number 560, F592
## 2026-10-08 09:59:57.944173 INFO::Fitting model to feature number 561, F593
## 2026-10-08 09:59:57.94541 INFO::Fitting model to feature number 562, F594
## 2026-10-08 09:59:57.946653 INFO::Fitting model to feature number 563, F595
## 2026-10-08 09:59:57.947895 INFO::Fitting model to feature number 564, F596
## 2026-10-08 09:59:57.949137 INFO::Fitting model to feature number 565, F597
## 2026-10-08 09:59:57.950389 INFO::Fitting model to feature number 566, F598
## 2026-10-08 09:59:57.951628 INFO::Fitting model to feature number 567, F599
## 2026-10-08 09:59:57.952871 INFO::Fitting model to feature number 568, F600
## 2026-10-08 09:59:57.954116 INFO::Fitting model to feature number 569, F601
## 2026-10-08 09:59:57.955365 INFO::Fitting model to feature number 570, F602
## 2026-10-08 09:59:57.956595 INFO::Fitting model to feature number 571, F603
## 2026-10-08 09:59:57.957855 INFO::Fitting model to feature number 572, F605
## 2026-10-08 09:59:57.959089 INFO::Fitting model to feature number 573, F606
## 2026-10-08 09:59:57.960329 INFO::Fitting model to feature number 574, F607
## 2026-10-08 09:59:57.961569 INFO::Fitting model to feature number 575, F608
## 2026-10-08 09:59:57.962797 INFO::Fitting model to feature number 576, F609
## 2026-10-08 09:59:57.964024 INFO::Fitting model to feature number 577, F610
## 2026-10-08 09:59:57.965262 INFO::Fitting model to feature number 578, F611
## 2026-10-08 09:59:57.966495 INFO::Fitting model to feature number 579, F612
## 2026-10-08 09:59:57.967794 INFO::Fitting model to feature number 580, F613
## 2026-10-08 09:59:57.969053 INFO::Fitting model to feature number 581, F614
## 2026-10-08 09:59:57.970318 INFO::Fitting model to feature number 582, F615
## 2026-10-08 09:59:57.971538 INFO::Fitting model to feature number 583, F616
## 2026-10-08 09:59:57.972765 INFO::Fitting model to feature number 584, F617
## 2026-10-08 09:59:57.973977 INFO::Fitting model to feature number 585, F618
## 2026-10-08 09:59:57.975296 INFO::Fitting model to feature number 586, F619
## 2026-10-08 09:59:57.98748 INFO::Fitting model to feature number 587, F620
## 2026-10-08 09:59:57.989317 INFO::Fitting model to feature number 588, F621
## 2026-10-08 09:59:57.990649 INFO::Fitting model to feature number 589, F622
## 2026-10-08 09:59:57.991947 INFO::Fitting model to feature number 590, F623
## 2026-10-08 09:59:57.993235 INFO::Fitting model to feature number 591, F624
## 2026-10-08 09:59:57.994526 INFO::Fitting model to feature number 592, F625
## 2026-10-08 09:59:57.995811 INFO::Fitting model to feature number 593, F626
## 2026-10-08 09:59:57.997092 INFO::Fitting model to feature number 594, F627
## 2026-10-08 09:59:57.99838 INFO::Fitting model to feature number 595, F628
## 2026-10-08 09:59:57.999658 INFO::Fitting model to feature number 596, F630
## 2026-10-08 09:59:58.000909 INFO::Fitting model to feature number 597, F631
## 2026-10-08 09:59:58.002153 INFO::Fitting model to feature number 598, F632
## 2026-10-08 09:59:58.003432 INFO::Fitting model to feature number 599, F633
## 2026-10-08 09:59:58.004686 INFO::Fitting model to feature number 600, F634
## 2026-10-08 09:59:58.005929 INFO::Fitting model to feature number 601, F635
## 2026-10-08 09:59:58.007152 INFO::Fitting model to feature number 602, F636
## 2026-10-08 09:59:58.00841 INFO::Fitting model to feature number 603, F637
## 2026-10-08 09:59:58.009681 INFO::Fitting model to feature number 604, F638
## 2026-10-08 09:59:58.010952 INFO::Fitting model to feature number 605, F639
## 2026-10-08 09:59:58.012235 INFO::Fitting model to feature number 606, F640
## 2026-10-08 09:59:58.0135 INFO::Fitting model to feature number 607, F641
## 2026-10-08 09:59:58.014843 INFO::Fitting model to feature number 608, F642
## 2026-10-08 09:59:58.016287 INFO::Fitting model to feature number 609, F643
## 2026-10-08 09:59:58.017737 INFO::Fitting model to feature number 610, F644
## 2026-10-08 09:59:58.019012 INFO::Fitting model to feature number 611, F645
## 2026-10-08 09:59:58.020392 INFO::Fitting model to feature number 612, F646
## 2026-10-08 09:59:58.021665 INFO::Fitting model to feature number 613, F647
## 2026-10-08 09:59:58.022939 INFO::Fitting model to feature number 614, F648
## 2026-10-08 09:59:58.024258 INFO::Fitting model to feature number 615, F649
## 2026-10-08 09:59:58.02555 INFO::Fitting model to feature number 616, F650
## 2026-10-08 09:59:58.026822 INFO::Fitting model to feature number 617, F651
## 2026-10-08 09:59:58.028095 INFO::Fitting model to feature number 618, F652
## 2026-10-08 09:59:58.029402 INFO::Fitting model to feature number 619, F653
## 2026-10-08 09:59:58.030663 INFO::Fitting model to feature number 620, F654
## 2026-10-08 09:59:58.031911 INFO::Fitting model to feature number 621, F655
## 2026-10-08 09:59:58.03318 INFO::Fitting model to feature number 622, F656
## 2026-10-08 09:59:58.034425 INFO::Fitting model to feature number 623, F657
## 2026-10-08 09:59:58.035636 INFO::Fitting model to feature number 624, F658
## 2026-10-08 09:59:58.03687 INFO::Fitting model to feature number 625, F659
## 2026-10-08 09:59:58.038079 INFO::Fitting model to feature number 626, F660
## 2026-10-08 09:59:58.039396 INFO::Fitting model to feature number 627, F661
## 2026-10-08 09:59:58.040644 INFO::Fitting model to feature number 628, F662
## 2026-10-08 09:59:58.041924 INFO::Fitting model to feature number 629, F663
## 2026-10-08 09:59:58.043222 INFO::Fitting model to feature number 630, F664
## 2026-10-08 09:59:58.044489 INFO::Fitting model to feature number 631, F665
## 2026-10-08 09:59:58.045929 INFO::Fitting model to feature number 632, F666
## 2026-10-08 09:59:58.047396 INFO::Fitting model to feature number 633, F667
## 2026-10-08 09:59:58.048759 INFO::Fitting model to feature number 634, F668
## 2026-10-08 09:59:58.050045 INFO::Fitting model to feature number 635, F669
## 2026-10-08 09:59:58.051398 INFO::Fitting model to feature number 636, F670
## 2026-10-08 09:59:58.052661 INFO::Fitting model to feature number 637, F671
## 2026-10-08 09:59:58.053919 INFO::Fitting model to feature number 638, F673
## 2026-10-08 09:59:58.055143 INFO::Fitting model to feature number 639, F674
## 2026-10-08 09:59:58.056435 INFO::Fitting model to feature number 640, F675
## 2026-10-08 09:59:58.057716 INFO::Fitting model to feature number 641, F676
## 2026-10-08 09:59:58.058955 INFO::Fitting model to feature number 642, F677
## 2026-10-08 09:59:58.06021 INFO::Fitting model to feature number 643, F678
## 2026-10-08 09:59:58.061439 INFO::Fitting model to feature number 644, F679
## 2026-10-08 09:59:58.062665 INFO::Fitting model to feature number 645, F680
## 2026-10-08 09:59:58.063879 INFO::Fitting model to feature number 646, F681
## 2026-10-08 09:59:58.06508 INFO::Fitting model to feature number 647, F682
## 2026-10-08 09:59:58.066282 INFO::Fitting model to feature number 648, F683
## 2026-10-08 09:59:58.067483 INFO::Fitting model to feature number 649, F684
## 2026-10-08 09:59:58.068674 INFO::Fitting model to feature number 650, F685
## 2026-10-08 09:59:58.069908 INFO::Fitting model to feature number 651, F686
## 2026-10-08 09:59:58.071126 INFO::Fitting model to feature number 652, F687
## 2026-10-08 09:59:58.072353 INFO::Fitting model to feature number 653, F688
## 2026-10-08 09:59:58.07356 INFO::Fitting model to feature number 654, F689
## 2026-10-08 09:59:58.074757 INFO::Fitting model to feature number 655, F690
## 2026-10-08 09:59:58.075966 INFO::Fitting model to feature number 656, F691
## 2026-10-08 09:59:58.077183 INFO::Fitting model to feature number 657, F692
## 2026-10-08 09:59:58.078456 INFO::Fitting model to feature number 658, F693
## 2026-10-08 09:59:58.079659 INFO::Fitting model to feature number 659, F694
## 2026-10-08 09:59:58.080855 INFO::Fitting model to feature number 660, F695
## 2026-10-08 09:59:58.08205 INFO::Fitting model to feature number 661, F696
## 2026-10-08 09:59:58.083288 INFO::Fitting model to feature number 662, F697
## 2026-10-08 09:59:58.084504 INFO::Fitting model to feature number 663, F698
## 2026-10-08 09:59:58.085742 INFO::Fitting model to feature number 664, F699
## 2026-10-08 09:59:58.086987 INFO::Fitting model to feature number 665, F700
## 2026-10-08 09:59:58.088233 INFO::Fitting model to feature number 666, F701
## 2026-10-08 09:59:58.089458 INFO::Fitting model to feature number 667, F702
## 2026-10-08 09:59:58.090671 INFO::Fitting model to feature number 668, F704
## 2026-10-08 09:59:58.091887 INFO::Fitting model to feature number 669, F705
## 2026-10-08 09:59:58.093102 INFO::Fitting model to feature number 670, F706
## 2026-10-08 09:59:58.094341 INFO::Fitting model to feature number 671, F707
## 2026-10-08 09:59:58.095641 INFO::Fitting model to feature number 672, F708
## 2026-10-08 09:59:58.09696 INFO::Fitting model to feature number 673, F709
## 2026-10-08 09:59:58.098255 INFO::Fitting model to feature number 674, F710
## 2026-10-08 09:59:58.099535 INFO::Fitting model to feature number 675, F711
## 2026-10-08 09:59:58.10082 INFO::Fitting model to feature number 676, F712
## 2026-10-08 09:59:58.102076 INFO::Fitting model to feature number 677, F713
## 2026-10-08 09:59:58.103352 INFO::Fitting model to feature number 678, F714
## 2026-10-08 09:59:58.104612 INFO::Fitting model to feature number 679, F715
## 2026-10-08 09:59:58.105849 INFO::Fitting model to feature number 680, F716
## 2026-10-08 09:59:58.107121 INFO::Fitting model to feature number 681, F717
## 2026-10-08 09:59:58.108406 INFO::Fitting model to feature number 682, F718
## 2026-10-08 09:59:58.109685 INFO::Fitting model to feature number 683, F719
## 2026-10-08 09:59:58.110948 INFO::Fitting model to feature number 684, F720
## 2026-10-08 09:59:58.112254 INFO::Fitting model to feature number 685, F721
## 2026-10-08 09:59:58.113529 INFO::Fitting model to feature number 686, F722
## 2026-10-08 09:59:58.11485 INFO::Fitting model to feature number 687, F723
## 2026-10-08 09:59:58.11616 INFO::Fitting model to feature number 688, F724
## 2026-10-08 09:59:58.117484 INFO::Fitting model to feature number 689, F725
## 2026-10-08 09:59:58.118756 INFO::Fitting model to feature number 690, F726
## 2026-10-08 09:59:58.120044 INFO::Fitting model to feature number 691, F727
## 2026-10-08 09:59:58.121331 INFO::Fitting model to feature number 692, F728
## 2026-10-08 09:59:58.122583 INFO::Fitting model to feature number 693, F729
## 2026-10-08 09:59:58.123846 INFO::Fitting model to feature number 694, F730
## 2026-10-08 09:59:58.125115 INFO::Fitting model to feature number 695, F731
## 2026-10-08 09:59:58.126418 INFO::Fitting model to feature number 696, F732
## 2026-10-08 09:59:58.127676 INFO::Fitting model to feature number 697, F733
## 2026-10-08 09:59:58.128931 INFO::Fitting model to feature number 698, F734
## 2026-10-08 09:59:58.130219 INFO::Fitting model to feature number 699, F735
## 2026-10-08 09:59:58.131545 INFO::Fitting model to feature number 700, F736
## 2026-10-08 09:59:58.132854 INFO::Fitting model to feature number 701, F737
## 2026-10-08 09:59:58.134114 INFO::Fitting model to feature number 702, F739
## 2026-10-08 09:59:58.135396 INFO::Fitting model to feature number 703, F740
## 2026-10-08 09:59:58.136672 INFO::Fitting model to feature number 704, F741
## 2026-10-08 09:59:58.137945 INFO::Fitting model to feature number 705, F742
## 2026-10-08 09:59:58.139219 INFO::Fitting model to feature number 706, F743
## 2026-10-08 09:59:58.140496 INFO::Fitting model to feature number 707, F745
## 2026-10-08 09:59:58.141752 INFO::Fitting model to feature number 708, F746
## 2026-10-08 09:59:58.143035 INFO::Fitting model to feature number 709, F747
## 2026-10-08 09:59:58.144307 INFO::Fitting model to feature number 710, F748
## 2026-10-08 09:59:58.145564 INFO::Fitting model to feature number 711, F749
## 2026-10-08 09:59:58.146878 INFO::Fitting model to feature number 712, F750
## 2026-10-08 09:59:58.148118 INFO::Fitting model to feature number 713, F751
## 2026-10-08 09:59:58.149363 INFO::Fitting model to feature number 714, F752
## 2026-10-08 09:59:58.150618 INFO::Fitting model to feature number 715, F753
## 2026-10-08 09:59:58.152004 INFO::Fitting model to feature number 716, F755
## 2026-10-08 09:59:58.153334 INFO::Fitting model to feature number 717, F756
## 2026-10-08 09:59:58.154578 INFO::Fitting model to feature number 718, F757
## 2026-10-08 09:59:58.155805 INFO::Fitting model to feature number 719, F758
## 2026-10-08 09:59:58.157021 INFO::Fitting model to feature number 720, F759
## 2026-10-08 09:59:58.15825 INFO::Fitting model to feature number 721, F760
## 2026-10-08 09:59:58.159467 INFO::Fitting model to feature number 722, F761
## 2026-10-08 09:59:58.160677 INFO::Fitting model to feature number 723, F762
## 2026-10-08 09:59:58.161915 INFO::Fitting model to feature number 724, F763
## 2026-10-08 09:59:58.163137 INFO::Fitting model to feature number 725, F764
## 2026-10-08 09:59:58.164362 INFO::Fitting model to feature number 726, F765
## 2026-10-08 09:59:58.165593 INFO::Fitting model to feature number 727, F766
## 2026-10-08 09:59:58.166814 INFO::Fitting model to feature number 728, F767
## 2026-10-08 09:59:58.168054 INFO::Fitting model to feature number 729, F768
## 2026-10-08 09:59:58.169279 INFO::Fitting model to feature number 730, F769
## 2026-10-08 09:59:58.170501 INFO::Fitting model to feature number 731, F770
## 2026-10-08 09:59:58.17171 INFO::Fitting model to feature number 732, F771
## 2026-10-08 09:59:58.172933 INFO::Fitting model to feature number 733, F772
## 2026-10-08 09:59:58.174169 INFO::Fitting model to feature number 734, F773
## 2026-10-08 09:59:58.175411 INFO::Fitting model to feature number 735, F774
## 2026-10-08 09:59:58.176642 INFO::Fitting model to feature number 736, F775
## 2026-10-08 09:59:58.177864 INFO::Fitting model to feature number 737, F776
## 2026-10-08 09:59:58.179083 INFO::Fitting model to feature number 738, F777
## 2026-10-08 09:59:58.180345 INFO::Fitting model to feature number 739, F778
## 2026-10-08 09:59:58.181615 INFO::Fitting model to feature number 740, F779
## 2026-10-08 09:59:58.182866 INFO::Fitting model to feature number 741, F780
## 2026-10-08 09:59:58.184116 INFO::Fitting model to feature number 742, F781
## 2026-10-08 09:59:58.185362 INFO::Fitting model to feature number 743, F782
## 2026-10-08 09:59:58.18664 INFO::Fitting model to feature number 744, F783
## 2026-10-08 09:59:58.187878 INFO::Fitting model to feature number 745, F784
## 2026-10-08 09:59:58.189116 INFO::Fitting model to feature number 746, F785
## 2026-10-08 09:59:58.190371 INFO::Fitting model to feature number 747, F786
## 2026-10-08 09:59:58.191652 INFO::Fitting model to feature number 748, F787
## 2026-10-08 09:59:58.192911 INFO::Fitting model to feature number 749, F788
## 2026-10-08 09:59:58.194141 INFO::Fitting model to feature number 750, F789
## 2026-10-08 09:59:58.19539 INFO::Fitting model to feature number 751, F790
## 2026-10-08 09:59:58.19667 INFO::Fitting model to feature number 752, F791
## 2026-10-08 09:59:58.197959 INFO::Fitting model to feature number 753, F792
## 2026-10-08 09:59:58.199225 INFO::Fitting model to feature number 754, F793
## 2026-10-08 09:59:58.200479 INFO::Fitting model to feature number 755, F794
## 2026-10-08 09:59:58.201739 INFO::Fitting model to feature number 756, F795
## 2026-10-08 09:59:58.203006 INFO::Fitting model to feature number 757, F796
## 2026-10-08 09:59:58.204309 INFO::Fitting model to feature number 758, F797
## 2026-10-08 09:59:58.205582 INFO::Fitting model to feature number 759, F798
## 2026-10-08 09:59:58.206857 INFO::Fitting model to feature number 760, F799
## 2026-10-08 09:59:58.208153 INFO::Fitting model to feature number 761, F800
## 2026-10-08 09:59:58.209424 INFO::Fitting model to feature number 762, F801
## 2026-10-08 09:59:58.210672 INFO::Fitting model to feature number 763, F802
## 2026-10-08 09:59:58.211917 INFO::Fitting model to feature number 764, F803
## 2026-10-08 09:59:58.213231 INFO::Fitting model to feature number 765, F804
## 2026-10-08 09:59:58.214508 INFO::Fitting model to feature number 766, F805
## 2026-10-08 09:59:58.215755 INFO::Fitting model to feature number 767, F806
## 2026-10-08 09:59:58.216995 INFO::Fitting model to feature number 768, F808
## 2026-10-08 09:59:58.218248 INFO::Fitting model to feature number 769, F809
## 2026-10-08 09:59:58.219508 INFO::Fitting model to feature number 770, F810
## 2026-10-08 09:59:58.220755 INFO::Fitting model to feature number 771, F811
## 2026-10-08 09:59:58.221995 INFO::Fitting model to feature number 772, F812
## 2026-10-08 09:59:58.223243 INFO::Fitting model to feature number 773, F813
## 2026-10-08 09:59:58.224465 INFO::Fitting model to feature number 774, F814
## 2026-10-08 09:59:58.225687 INFO::Fitting model to feature number 775, F815
## 2026-10-08 09:59:58.226905 INFO::Fitting model to feature number 776, F816
## 2026-10-08 09:59:58.228131 INFO::Fitting model to feature number 777, F817
## 2026-10-08 09:59:58.229375 INFO::Fitting model to feature number 778, F818
## 2026-10-08 09:59:58.230614 INFO::Fitting model to feature number 779, F819
## 2026-10-08 09:59:58.231859 INFO::Fitting model to feature number 780, F820
## 2026-10-08 09:59:58.233103 INFO::Fitting model to feature number 781, F821
## 2026-10-08 09:59:58.23435 INFO::Fitting model to feature number 782, F822
## 2026-10-08 09:59:58.235577 INFO::Fitting model to feature number 783, F823
## 2026-10-08 09:59:58.236838 INFO::Fitting model to feature number 784, F824
## 2026-10-08 09:59:58.238079 INFO::Fitting model to feature number 785, F825
## 2026-10-08 09:59:58.239335 INFO::Fitting model to feature number 786, F826
## 2026-10-08 09:59:58.240554 INFO::Fitting model to feature number 787, F827
## 2026-10-08 09:59:58.241786 INFO::Fitting model to feature number 788, F828
## 2026-10-08 09:59:58.24301 INFO::Fitting model to feature number 789, F829
## 2026-10-08 09:59:58.244232 INFO::Fitting model to feature number 790, F830
## 2026-10-08 09:59:58.245472 INFO::Fitting model to feature number 791, F831
## 2026-10-08 09:59:58.246692 INFO::Fitting model to feature number 792, F832
## 2026-10-08 09:59:58.247913 INFO::Fitting model to feature number 793, F833
## 2026-10-08 09:59:58.249151 INFO::Fitting model to feature number 794, F834
## 2026-10-08 09:59:58.250386 INFO::Fitting model to feature number 795, F835
## 2026-10-08 09:59:58.251611 INFO::Fitting model to feature number 796, F836
## 2026-10-08 09:59:58.252847 INFO::Fitting model to feature number 797, F837
## 2026-10-08 09:59:58.254101 INFO::Fitting model to feature number 798, F838
## 2026-10-08 09:59:58.255365 INFO::Fitting model to feature number 799, F839
## 2026-10-08 09:59:58.256599 INFO::Fitting model to feature number 800, F840
## 2026-10-08 09:59:58.25782 INFO::Fitting model to feature number 801, F841
## 2026-10-08 09:59:58.259038 INFO::Fitting model to feature number 802, F842
## 2026-10-08 09:59:58.260273 INFO::Fitting model to feature number 803, F843
## 2026-10-08 09:59:58.261503 INFO::Fitting model to feature number 804, F844
## 2026-10-08 09:59:58.262749 INFO::Fitting model to feature number 805, F845
## 2026-10-08 09:59:58.26399 INFO::Fitting model to feature number 806, F847
## 2026-10-08 09:59:58.265236 INFO::Fitting model to feature number 807, F848
## 2026-10-08 09:59:58.266467 INFO::Fitting model to feature number 808, F849
## 2026-10-08 09:59:58.2677 INFO::Fitting model to feature number 809, F850
## 2026-10-08 09:59:58.268965 INFO::Fitting model to feature number 810, F851
## 2026-10-08 09:59:58.270228 INFO::Fitting model to feature number 811, F852
## 2026-10-08 09:59:58.271465 INFO::Fitting model to feature number 812, F853
## 2026-10-08 09:59:58.272685 INFO::Fitting model to feature number 813, F854
## 2026-10-08 09:59:58.273902 INFO::Fitting model to feature number 814, F855
## 2026-10-08 09:59:58.275129 INFO::Fitting model to feature number 815, F856
## 2026-10-08 09:59:58.276385 INFO::Fitting model to feature number 816, F857
## 2026-10-08 09:59:58.277586 INFO::Fitting model to feature number 817, F858
## 2026-10-08 09:59:58.278792 INFO::Fitting model to feature number 818, F859
## 2026-10-08 09:59:58.280013 INFO::Fitting model to feature number 819, F860
## 2026-10-08 09:59:58.281237 INFO::Fitting model to feature number 820, F861
## 2026-10-08 09:59:58.282441 INFO::Fitting model to feature number 821, F862
## 2026-10-08 09:59:58.283642 INFO::Fitting model to feature number 822, F863
## 2026-10-08 09:59:58.28486 INFO::Fitting model to feature number 823, F864
## 2026-10-08 09:59:58.286088 INFO::Fitting model to feature number 824, F865
## 2026-10-08 09:59:58.287371 INFO::Fitting model to feature number 825, F866
## 2026-10-08 09:59:58.2886 INFO::Fitting model to feature number 826, F867
## 2026-10-08 09:59:58.289833 INFO::Fitting model to feature number 827, F868
## 2026-10-08 09:59:58.291053 INFO::Fitting model to feature number 828, F869
## 2026-10-08 09:59:58.292293 INFO::Fitting model to feature number 829, F870
## 2026-10-08 09:59:58.293522 INFO::Fitting model to feature number 830, F871
## 2026-10-08 09:59:58.294746 INFO::Fitting model to feature number 831, F872
## 2026-10-08 09:59:58.295974 INFO::Fitting model to feature number 832, F873
## 2026-10-08 09:59:58.297213 INFO::Fitting model to feature number 833, F874
## 2026-10-08 09:59:58.298435 INFO::Fitting model to feature number 834, F875
## 2026-10-08 09:59:58.299671 INFO::Fitting model to feature number 835, F876
## 2026-10-08 09:59:58.300932 INFO::Fitting model to feature number 836, F877
## 2026-10-08 09:59:58.302274 INFO::Fitting model to feature number 837, F878
## 2026-10-08 09:59:58.31436 INFO::Fitting model to feature number 838, F879
## 2026-10-08 09:59:58.316152 INFO::Fitting model to feature number 839, F880
## 2026-10-08 09:59:58.317482 INFO::Fitting model to feature number 840, F881
## 2026-10-08 09:59:58.318795 INFO::Fitting model to feature number 841, F882
## 2026-10-08 09:59:58.320097 INFO::Fitting model to feature number 842, F883
## 2026-10-08 09:59:58.321436 INFO::Fitting model to feature number 843, F884
## 2026-10-08 09:59:58.322735 INFO::Fitting model to feature number 844, F885
## 2026-10-08 09:59:58.324053 INFO::Fitting model to feature number 845, F886
## 2026-10-08 09:59:58.325369 INFO::Fitting model to feature number 846, F887
## 2026-10-08 09:59:58.326656 INFO::Fitting model to feature number 847, F888
## 2026-10-08 09:59:58.327948 INFO::Fitting model to feature number 848, F889
## 2026-10-08 09:59:58.329241 INFO::Fitting model to feature number 849, F890
## 2026-10-08 09:59:58.330512 INFO::Fitting model to feature number 850, F891
## 2026-10-08 09:59:58.331788 INFO::Fitting model to feature number 851, F892
## 2026-10-08 09:59:58.333042 INFO::Fitting model to feature number 852, F893
## 2026-10-08 09:59:58.334312 INFO::Fitting model to feature number 853, F894
## 2026-10-08 09:59:58.335568 INFO::Fitting model to feature number 854, F895
## 2026-10-08 09:59:58.33684 INFO::Fitting model to feature number 855, F896
## 2026-10-08 09:59:58.338109 INFO::Fitting model to feature number 856, F897
## 2026-10-08 09:59:58.339395 INFO::Fitting model to feature number 857, F898
## 2026-10-08 09:59:58.340661 INFO::Fitting model to feature number 858, F899
## 2026-10-08 09:59:58.341945 INFO::Fitting model to feature number 859, F900
## 2026-10-08 09:59:58.411614 INFO::Counting total values for each feature
## 2026-10-08 09:59:58.457942 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2026-10-08 09:59:58.491945 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2026-10-08 09:59:58.5253 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2026-10-08 09:59:58.559391 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2026-10-08 09:59:58.579642 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2026-10-08 09:59:58.596125 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2026-10-08 09:59:58.601674 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2026-10-08 09:59:58.604207 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2026-10-08 09:59:58.611662 INFO::Plotting associations from most to least significant, grouped by metadata
## 2026-10-08 09:59:58.61206 INFO::Plotting data for metadata number 1, diagnosis
## 2026-10-08 09:59:58.627959 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2026-10-08 09:59:58.808626 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2026-10-08 09:59:58.926743 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2026-10-08 09:59:59.036933 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2026-10-08 09:59:59.154845 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2026-10-08 09:59:59.263917 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2026-10-08 09:59:59.381624 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2026-10-08 09:59:59.49245 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2026-10-08 09:59:59.606291 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2026-10-08 09:59:59.721793 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2026-10-08 09:59:59.836249 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2026-10-08 09:59:59.957047 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2026-10-08 10:00:00.070965 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2026-10-08 10:00:00.316448 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2026-10-08 10:00:00.428293 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2026-10-08 10:00:00.549023 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2026-10-08 10:00:00.660179 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2026-10-08 10:00:00.769181 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2026-10-08 10:00:00.888309 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2026-10-08 10:00:00.998019 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2026-10-08 10:00:01.11737 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2026-10-08 10:00:01.226497 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2026-10-08 10:00:01.342445 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2026-10-08 10:00:01.452256 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2026-10-08 10:00:01.567814 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2026-10-08 10:00:01.677817 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2026-10-08 10:00:01.784727 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2026-10-08 10:00:01.900695 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2026-10-08 10:00:02.008801 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2026-10-08 10:00:02.125346 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2026-10-08 10:00:02.23396 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2026-10-08 10:00:02.348733 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2026-10-08 10:00:02.464679 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2026-10-08 10:00:02.585625 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2026-10-08 10:00:02.695439 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2026-10-08 10:00:02.813121 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2026-10-08 10:00:02.982608 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2026-10-08 10:00:03.103401 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2026-10-08 10:00:03.226668 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2026-10-08 10:00:03.348639 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2026-10-08 10:00:03.495483 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2026-10-08 10:00:03.607693 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2026-10-08 10:00:03.728474 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2026-10-08 10:00:03.843928 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2026-10-08 10:00:03.976205 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2026-10-08 10:00:04.09434 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2026-10-08 10:00:04.220032 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2026-10-08 10:00:04.337174 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2026-10-08 10:00:04.460938 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2026-10-08 10:00:04.576721 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2026-10-08 10:00:04.699454 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2026-10-08 10:00:04.81321 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2026-10-08 10:00:04.930867 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2026-10-08 10:00:05.04106 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2026-10-08 10:00:05.159139 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2026-10-08 10:00:05.27203 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2026-10-08 10:00:05.389993 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2026-10-08 10:00:05.499424 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2026-10-08 10:00:05.667722 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2026-10-08 10:00:05.784914 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2026-10-08 10:00:05.899391 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2026-10-08 10:00:06.032813 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2026-10-08 10:00:06.146677 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2026-10-08 10:00:06.277816 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2026-10-08 10:00:06.430834 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2026-10-08 10:00:06.580673 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2026-10-08 10:00:06.695587 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2026-10-08 10:00:06.821685 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2026-10-08 10:00:06.942079 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2026-10-08 10:00:07.053791 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2026-10-08 10:00:07.184645 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2026-10-08 10:00:07.294751 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2026-10-08 10:00:07.422164 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2026-10-08 10:00:07.541278 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2026-10-08 10:00:07.671117 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2026-10-08 10:00:07.78718 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2026-10-08 10:00:07.917209 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2026-10-08 10:00:08.031566 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2026-10-08 10:00:08.151166 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2026-10-08 10:00:08.273833 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2026-10-08 10:00:08.387225 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2026-10-08 10:00:08.516374 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2026-10-08 10:00:08.626609 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2026-10-08 10:00:08.761413 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2026-10-08 10:00:08.87716 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2026-10-08 10:00:09.006223 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2026-10-08 10:00:09.118081 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2026-10-08 10:00:09.244724 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2026-10-08 10:00:09.356841 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2026-10-08 10:00:09.482236 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2026-10-08 10:00:09.597453 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2026-10-08 10:00:09.723664 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2026-10-08 10:00:09.837407 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2026-10-08 10:00:09.965744 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2026-10-08 10:00:10.076737 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2026-10-08 10:00:10.202794 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2026-10-08 10:00:10.314707 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2026-10-08 10:00:10.442716 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2026-10-08 10:00:10.557926 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2026-10-08 10:00:10.685591 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2026-10-08 10:00:10.801218 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2026-10-08 10:00:10.928644 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2026-10-08 10:00:11.045375 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2026-10-08 10:00:11.225803 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2026-10-08 10:00:11.344678 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2026-10-08 10:00:11.464144 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2026-10-08 10:00:11.599673 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2026-10-08 10:00:11.729155 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2026-10-08 10:00:11.863286 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2026-10-08 10:00:11.981742 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2026-10-08 10:00:12.113981 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2026-10-08 10:00:12.23062 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2026-10-08 10:00:12.352021 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2026-10-08 10:00:12.474668 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2026-10-08 10:00:12.594476 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2026-10-08 10:00:12.737762 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2026-10-08 10:00:12.864111 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2026-10-08 10:00:13.002798 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2026-10-08 10:00:13.122344 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2026-10-08 10:00:13.255104 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2026-10-08 10:00:13.418588 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2026-10-08 10:00:13.550526 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2026-10-08 10:00:13.671026 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2026-10-08 10:00:13.79876 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2026-10-08 10:00:13.924762 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2026-10-08 10:00:14.044428 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2026-10-08 10:00:14.178367 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2026-10-08 10:00:14.296641 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2026-10-08 10:00:14.43063 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2026-10-08 10:00:14.549393 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2026-10-08 10:00:14.68377 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2026-10-08 10:00:14.8046 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2026-10-08 10:00:14.93479 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2026-10-08 10:00:15.053468 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2026-10-08 10:00:15.185914 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2026-10-08 10:00:15.308146 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2026-10-08 10:00:15.437553 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2026-10-08 10:00:15.557682 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2026-10-08 10:00:15.683897 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2026-10-08 10:00:15.804133 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2026-10-08 10:00:15.934595 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2026-10-08 10:00:16.055694 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2026-10-08 10:00:16.184193 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2026-10-08 10:00:16.303762 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2026-10-08 10:00:16.431601 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2026-10-08 10:00:16.552304 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2026-10-08 10:00:16.681283 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2026-10-08 10:00:16.803936 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2026-10-08 10:00:17.556487 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2026-10-08 10:00:17.668779 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2026-10-08 10:00:17.780846 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2026-10-08 10:00:17.895526 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2026-10-08 10:00:18.006918 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2026-10-08 10:00:18.157096 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2026-10-08 10:00:18.267627 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2026-10-08 10:00:18.383702 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2026-10-08 10:00:18.491808 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2026-10-08 10:00:18.607882 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2026-10-08 10:00:18.715226 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2026-10-08 10:00:18.825688 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2026-10-08 10:00:18.939033 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2026-10-08 10:00:19.049575 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2026-10-08 10:00:19.162495 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2026-10-08 10:00:19.271272 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2026-10-08 10:00:19.386715 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2026-10-08 10:00:19.492178 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2026-10-08 10:00:19.606648 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2026-10-08 10:00:19.713841 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2026-10-08 10:00:19.823382 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2026-10-08 10:00:19.93605 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2026-10-08 10:00:20.04693 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2026-10-08 10:00:20.162884 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2026-10-08 10:00:20.268726 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2026-10-08 10:00:20.378567 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2026-10-08 10:00:20.487293 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2026-10-08 10:00:20.600042 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2026-10-08 10:00:20.7083 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2026-10-08 10:00:20.832773 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2026-10-08 10:00:20.938733 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2026-10-08 10:00:21.05638 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2026-10-08 10:00:21.167649 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2026-10-08 10:00:21.28248 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2026-10-08 10:00:21.389683 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2026-10-08 10:00:21.497931 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2026-10-08 10:00:21.608085 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2026-10-08 10:00:21.718379 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2026-10-08 10:00:21.829553 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2026-10-08 10:00:21.939408 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2026-10-08 10:00:22.052033 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2026-10-08 10:00:22.160225 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2026-10-08 10:00:22.272017 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2026-10-08 10:00:22.38452 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2026-10-08 10:00:22.502065 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2026-10-08 10:00:22.620168 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2026-10-08 10:00:22.801279 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2026-10-08 10:00:22.924479 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2026-10-08 10:00:23.059193 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2026-10-08 10:00:23.181622 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2026-10-08 10:00:23.306967 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2026-10-08 10:00:23.425449 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2026-10-08 10:00:23.537151 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2026-10-08 10:00:23.667836 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2026-10-08 10:00:23.784442 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2026-10-08 10:00:23.919437 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2026-10-08 10:00:24.03991 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2026-10-08 10:00:24.173173 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2026-10-08 10:00:24.294944 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2026-10-08 10:00:24.425084 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2026-10-08 10:00:24.544429 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2026-10-08 10:00:24.657156 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2026-10-08 10:00:24.790483 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2026-10-08 10:00:24.90584 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2026-10-08 10:00:25.033949 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2026-10-08 10:00:25.149267 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2026-10-08 10:00:25.277161 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2026-10-08 10:00:25.393058 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2026-10-08 10:00:25.523671 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2026-10-08 10:00:25.638067 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2026-10-08 10:00:25.760578 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2026-10-08 10:00:25.878699 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2026-10-08 10:00:26.000375 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2026-10-08 10:00:26.1207 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2026-10-08 10:00:26.231788 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2026-10-08 10:00:26.359969 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2026-10-08 10:00:26.468363 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2026-10-08 10:00:26.595148 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2026-10-08 10:00:26.709716 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2026-10-08 10:00:26.833011 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2026-10-08 10:00:26.943032 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2026-10-08 10:00:27.069714 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2026-10-08 10:00:27.183601 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2026-10-08 10:00:27.312398 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2026-10-08 10:00:27.430577 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2026-10-08 10:00:27.56083 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2026-10-08 10:00:27.678457 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2026-10-08 10:00:27.807396 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2026-10-08 10:00:27.925668 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2026-10-08 10:00:28.055257 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2026-10-08 10:00:28.169503 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2026-10-08 10:00:28.348672 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2026-10-08 10:00:28.465771 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2026-10-08 10:00:28.604581 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2026-10-08 10:00:28.72219 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2026-10-08 10:00:28.837117 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2026-10-08 10:00:28.976972 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2026-10-08 10:00:29.095687 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2026-10-08 10:00:29.236009 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2026-10-08 10:00:29.355787 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2026-10-08 10:00:29.495357 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2026-10-08 10:00:29.612766 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2026-10-08 10:00:29.744528 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2026-10-08 10:00:29.873026 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2026-10-08 10:00:29.988956 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2026-10-08 10:00:30.128898 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2026-10-08 10:00:30.249189 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2026-10-08 10:00:30.38604 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2026-10-08 10:00:30.504063 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2026-10-08 10:00:30.640779 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2026-10-08 10:00:30.756082 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2026-10-08 10:00:30.895804 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2026-10-08 10:00:31.015307 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2026-10-08 10:00:31.15178 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2026-10-08 10:00:31.274507 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2026-10-08 10:00:31.396783 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2026-10-08 10:00:31.532132 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2026-10-08 10:00:31.647856 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2026-10-08 10:00:31.796755 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2026-10-08 10:00:31.923299 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2026-10-08 10:00:32.065306 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2026-10-08 10:00:32.186738 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2026-10-08 10:00:32.328896 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2026-10-08 10:00:32.456303 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2026-10-08 10:00:32.603171 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2026-10-08 10:00:32.727521 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2026-10-08 10:00:32.867678 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2026-10-08 10:00:32.996623 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2026-10-08 10:00:33.151062 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2026-10-08 10:00:33.284016 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2026-10-08 10:00:33.43345 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2026-10-08 10:00:33.557551 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2026-10-08 10:00:33.703035 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2026-10-08 10:00:33.835441 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2026-10-08 10:00:33.983838 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2026-10-08 10:00:34.112498 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2026-10-08 10:00:34.31681 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2026-10-08 10:00:34.438476 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2026-10-08 10:00:34.571155 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2026-10-08 10:00:34.699467 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2026-10-08 10:00:34.824055 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2026-10-08 10:00:34.970632 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2026-10-08 10:00:35.099165 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2026-10-08 10:00:35.24738 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2026-10-08 10:00:35.376188 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2026-10-08 10:00:35.518434 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2026-10-08 10:00:35.640641 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2026-10-08 10:00:35.769123 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2026-10-08 10:00:35.903815 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2026-10-08 10:00:36.023783 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2026-10-08 10:00:36.166225 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2026-10-08 10:00:36.286843 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2026-10-08 10:00:36.428756 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2026-10-08 10:00:36.550763 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2026-10-08 10:00:36.691634 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2026-10-08 10:00:36.81472 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2026-10-08 10:00:36.956798 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2026-10-08 10:00:37.083385 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2026-10-08 10:00:37.216549 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2026-10-08 10:00:37.343484 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2026-10-08 10:00:37.502129 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2026-10-08 10:00:37.650752 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2026-10-08 10:00:37.773787 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2026-10-08 10:00:37.916964 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2026-10-08 10:00:38.039037 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2026-10-08 10:00:38.178666 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2026-10-08 10:00:38.298869 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2026-10-08 10:00:38.440687 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2026-10-08 10:00:38.563127 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2026-10-08 10:00:38.7029 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2026-10-08 10:00:38.823034 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2026-10-08 10:00:38.96183 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2026-10-08 10:00:39.083048 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2026-10-08 10:00:39.227979 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2026-10-08 10:00:39.350685 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2026-10-08 10:00:39.489865 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2026-10-08 10:00:39.610691 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2026-10-08 10:00:39.750224 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2026-10-08 10:00:39.875068 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2026-10-08 10:00:40.013697 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2026-10-08 10:00:40.137071 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2026-10-08 10:00:40.332251 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2026-10-08 10:00:40.45832 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2026-10-08 10:00:40.589375 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2026-10-08 10:00:40.735639 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2026-10-08 10:00:40.859711 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2026-10-08 10:00:41.016121 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2026-10-08 10:00:41.142576 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2026-10-08 10:00:41.298282 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2026-10-08 10:00:41.425034 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2026-10-08 10:00:41.575557 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2026-10-08 10:00:41.710344 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2026-10-08 10:00:41.841425 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2026-10-08 10:00:41.995742 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2026-10-08 10:00:42.130975 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2026-10-08 10:00:42.286136 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2026-10-08 10:00:42.412689 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2026-10-08 10:00:42.57231 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2026-10-08 10:00:42.703038 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2026-10-08 10:00:42.865166 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2026-10-08 10:00:42.996334 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2026-10-08 10:00:43.152376 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2026-10-08 10:00:43.289878 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2026-10-08 10:00:43.42603 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2026-10-08 10:00:43.573811 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2026-10-08 10:00:43.697912 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2026-10-08 10:00:43.863099 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2026-10-08 10:00:43.991901 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2026-10-08 10:00:44.150184 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2026-10-08 10:00:44.279576 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2026-10-08 10:00:44.438862 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2026-10-08 10:00:44.563365 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2026-10-08 10:00:44.716186 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2026-10-08 10:00:44.843889 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2026-10-08 10:00:45.000117 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2026-10-08 10:00:45.126136 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2026-10-08 10:00:45.277339 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2026-10-08 10:00:45.401807 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2026-10-08 10:00:45.553994 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2026-10-08 10:00:45.677215 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2026-10-08 10:00:45.82661 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2026-10-08 10:00:45.95135 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2026-10-08 10:00:46.101644 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2026-10-08 10:00:46.226207 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2026-10-08 10:00:46.373601 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2026-10-08 10:00:46.495289 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2026-10-08 10:00:46.706863 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2026-10-08 10:00:46.833685 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2026-10-08 10:00:46.980926 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2026-10-08 10:00:47.115261 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2026-10-08 10:00:47.23932 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2026-10-08 10:00:47.391451 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2026-10-08 10:00:47.5203 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2026-10-08 10:00:47.671674 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2026-10-08 10:00:47.801231 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2026-10-08 10:00:47.954706 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2026-10-08 10:00:48.078897 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2026-10-08 10:00:48.213617 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2026-10-08 10:00:48.348582 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2026-10-08 10:00:48.467699 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2026-10-08 10:00:48.618039 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2026-10-08 10:00:48.740646 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2026-10-08 10:00:48.890268 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2026-10-08 10:00:49.016237 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2026-10-08 10:00:49.165418 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2026-10-08 10:00:49.285827 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2026-10-08 10:00:49.435013 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2026-10-08 10:00:49.571339 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2026-10-08 10:00:49.721584 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2026-10-08 10:00:49.856929 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2026-10-08 10:00:49.992406 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2026-10-08 10:00:50.136127 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2026-10-08 10:00:50.261046 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2026-10-08 10:00:50.413191 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2026-10-08 10:00:50.538426 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2026-10-08 10:00:50.684889 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2026-10-08 10:00:50.816911 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2026-10-08 10:00:51.025523 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2026-10-08 10:00:51.154297 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2026-10-08 10:00:51.299904 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2026-10-08 10:00:51.422228 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2026-10-08 10:00:51.571421 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2026-10-08 10:00:51.69824 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2026-10-08 10:00:51.845162 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2026-10-08 10:00:51.96963 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2026-10-08 10:00:52.116919 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2026-10-08 10:00:52.244206 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2026-10-08 10:00:52.394264 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2026-10-08 10:00:52.520252 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2026-10-08 10:00:52.671013 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2026-10-08 10:00:52.803464 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2026-10-08 10:00:53.555246 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2026-10-08 10:00:53.665893 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2026-10-08 10:00:53.785137 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2026-10-08 10:00:53.897758 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2026-10-08 10:00:54.01096 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2026-10-08 10:00:54.127341 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2026-10-08 10:00:54.239045 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2026-10-08 10:00:54.354284 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2026-10-08 10:00:54.464546 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2026-10-08 10:00:54.583582 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2026-10-08 10:00:54.693466 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2026-10-08 10:00:54.809993 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2026-10-08 10:00:54.914392 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2026-10-08 10:00:55.022699 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2026-10-08 10:00:55.137305 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2026-10-08 10:00:55.2466 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2026-10-08 10:00:55.365213 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2026-10-08 10:00:55.477993 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2026-10-08 10:00:55.596235 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2026-10-08 10:00:55.706591 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2026-10-08 10:00:55.824441 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2026-10-08 10:00:55.934616 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2026-10-08 10:00:56.053032 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2026-10-08 10:00:56.161793 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2026-10-08 10:00:56.273363 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2026-10-08 10:00:56.386589 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2026-10-08 10:00:56.513168 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2026-10-08 10:00:56.628304 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2026-10-08 10:00:56.737172 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2026-10-08 10:00:56.852725 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2026-10-08 10:00:56.967635 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2026-10-08 10:00:57.085253 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2026-10-08 10:00:57.195257 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2026-10-08 10:00:57.312694 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2026-10-08 10:00:57.422036 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2026-10-08 10:00:57.538957 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2026-10-08 10:00:57.651125 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2026-10-08 10:00:57.771326 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2026-10-08 10:00:57.88241 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2026-10-08 10:00:58.003733 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2026-10-08 10:00:58.111429 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2026-10-08 10:00:58.227909 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2026-10-08 10:00:58.33754 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2026-10-08 10:00:58.460509 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2026-10-08 10:00:58.570513 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2026-10-08 10:00:58.745422 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2026-10-08 10:00:58.86753 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2026-10-08 10:00:58.984887 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2026-10-08 10:00:59.118936 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2026-10-08 10:00:59.232968 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2026-10-08 10:00:59.361674 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2026-10-08 10:00:59.481152 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2026-10-08 10:00:59.611642 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2026-10-08 10:00:59.731628 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2026-10-08 10:00:59.858158 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2026-10-08 10:00:59.979897 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2026-10-08 10:01:00.087631 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2026-10-08 10:01:00.257457 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2026-10-08 10:01:00.373393 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2026-10-08 10:01:00.51065 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2026-10-08 10:01:00.63113 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2026-10-08 10:01:00.822454 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2026-10-08 10:01:00.945302 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2026-10-08 10:01:01.075364 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2026-10-08 10:01:01.199167 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2026-10-08 10:01:01.323868 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2026-10-08 10:01:01.45929 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2026-10-08 10:01:01.581916 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2026-10-08 10:01:01.723383 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2026-10-08 10:01:01.845405 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2026-10-08 10:01:01.983283 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2026-10-08 10:01:02.10655 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2026-10-08 10:01:02.239092 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2026-10-08 10:01:02.357204 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2026-10-08 10:01:02.490728 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2026-10-08 10:01:02.614413 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2026-10-08 10:01:02.747208 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2026-10-08 10:01:02.870757 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2026-10-08 10:01:03.008216 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2026-10-08 10:01:03.136754 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2026-10-08 10:01:03.272757 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2026-10-08 10:01:03.396361 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2026-10-08 10:01:03.529123 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2026-10-08 10:01:03.652943 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2026-10-08 10:01:03.78532 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2026-10-08 10:01:03.91404 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2026-10-08 10:01:04.043869 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2026-10-08 10:01:04.17074 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2026-10-08 10:01:04.305544 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2026-10-08 10:01:04.436238 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2026-10-08 10:01:04.614602 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2026-10-08 10:01:04.756094 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2026-10-08 10:01:04.881576 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2026-10-08 10:01:05.040271 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2026-10-08 10:01:05.166155 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2026-10-08 10:01:05.366497 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2026-10-08 10:01:05.503937 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2026-10-08 10:01:05.652453 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2026-10-08 10:01:05.776131 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2026-10-08 10:01:05.907649 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2026-10-08 10:01:06.047867 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2026-10-08 10:01:06.195971 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2026-10-08 10:01:06.365514 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2026-10-08 10:01:06.491933 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2026-10-08 10:01:06.639557 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2026-10-08 10:01:06.764034 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2026-10-08 10:01:06.906902 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2026-10-08 10:01:07.033283 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2026-10-08 10:01:07.184651 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2026-10-08 10:01:07.324005 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2026-10-08 10:01:07.470222 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2026-10-08 10:01:07.628577 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2026-10-08 10:01:07.761701 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2026-10-08 10:01:07.92038 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2026-10-08 10:01:08.048284 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2026-10-08 10:01:08.20208 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2026-10-08 10:01:08.331802 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2026-10-08 10:01:08.485388 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2026-10-08 10:01:08.611209 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2026-10-08 10:01:08.768085 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2026-10-08 10:01:08.893278 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2026-10-08 10:01:09.042055 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2026-10-08 10:01:09.167493 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2026-10-08 10:01:09.318744 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2026-10-08 10:01:09.44322 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2026-10-08 10:01:09.586067 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2026-10-08 10:01:09.715314 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2026-10-08 10:01:09.858898 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2026-10-08 10:01:09.990849 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2026-10-08 10:01:10.131116 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2026-10-08 10:01:10.262574 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2026-10-08 10:01:10.395489 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2026-10-08 10:01:10.527595 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2026-10-08 10:01:10.662121 INFO::Creating boxplot for categorical data, diagnosis vs F730
## 2026-10-08 10:01:12.185668 INFO::Plotting data for metadata number 2, antibiotics
## 2026-10-08 10:01:12.186695 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2026-10-08 10:01:12.334932 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2026-10-08 10:01:12.463444 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2026-10-08 10:01:12.598602 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2026-10-08 10:01:12.74394 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2026-10-08 10:01:12.875066 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2026-10-08 10:01:13.035588 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2026-10-08 10:01:13.166829 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2026-10-08 10:01:13.319305 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2026-10-08 10:01:13.448065 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2026-10-08 10:01:13.597415 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2026-10-08 10:01:13.742289 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2026-10-08 10:01:13.895638 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2026-10-08 10:01:14.02484 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2026-10-08 10:01:14.178557 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2026-10-08 10:01:14.309401 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2026-10-08 10:01:14.456856 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2026-10-08 10:01:14.585685 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2026-10-08 10:01:14.73723 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2026-10-08 10:01:14.869294 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2026-10-08 10:01:15.019579 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2026-10-08 10:01:15.150969 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2026-10-08 10:01:15.30173 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2026-10-08 10:01:15.434805 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2026-10-08 10:01:15.584131 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2026-10-08 10:01:15.716636 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2026-10-08 10:01:15.869845 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2026-10-08 10:01:16.006278 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2026-10-08 10:01:16.162083 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2026-10-08 10:01:16.300205 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2026-10-08 10:01:16.460288 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2026-10-08 10:01:16.604829 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2026-10-08 10:01:16.760774 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2026-10-08 10:01:16.899438 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2026-10-08 10:01:17.065594 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2026-10-08 10:01:17.206538 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2026-10-08 10:01:17.373501 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2026-10-08 10:01:17.508301 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2026-10-08 10:01:17.757994 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2026-10-08 10:01:17.893151 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2026-10-08 10:01:18.062053 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2026-10-08 10:01:18.198689 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2026-10-08 10:01:18.372185 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2026-10-08 10:01:18.506009 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2026-10-08 10:01:18.675354 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2026-10-08 10:01:18.816567 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2026-10-08 10:01:18.988989 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2026-10-08 10:01:19.129232 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2026-10-08 10:01:19.300028 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2026-10-08 10:01:19.439654 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2026-10-08 10:01:19.613219 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2026-10-08 10:01:19.747975 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2026-10-08 10:01:19.92268 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2026-10-08 10:01:20.06094 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2026-10-08 10:01:20.230311 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2026-10-08 10:01:20.366843 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2026-10-08 10:01:20.53091 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2026-10-08 10:01:20.663677 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2026-10-08 10:01:20.836017 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2026-10-08 10:01:20.974523 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2026-10-08 10:01:21.143268 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2026-10-08 10:01:21.279896 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2026-10-08 10:01:21.450319 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2026-10-08 10:01:21.590215 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2026-10-08 10:01:21.768177 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2026-10-08 10:01:21.910336 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2026-10-08 10:01:22.085114 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2026-10-08 10:01:22.223702 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2026-10-08 10:01:22.388038 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2026-10-08 10:01:22.523496 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2026-10-08 10:01:22.694264 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2026-10-08 10:01:22.828964 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2026-10-08 10:01:23.005103 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2026-10-08 10:01:23.153713 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2026-10-08 10:01:23.311506 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2026-10-08 10:01:23.474345 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2026-10-08 10:01:23.617945 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2026-10-08 10:01:23.784841 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2026-10-08 10:01:23.924559 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2026-10-08 10:01:24.154663 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2026-10-08 10:01:24.292498 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2026-10-08 10:01:24.46081 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2026-10-08 10:01:24.601407 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2026-10-08 10:01:24.768366 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2026-10-08 10:01:24.90791 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2026-10-08 10:01:25.076987 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2026-10-08 10:01:25.216844 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2026-10-08 10:01:25.386507 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2026-10-08 10:01:25.529177 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2026-10-08 10:01:25.693784 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2026-10-08 10:01:25.837655 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2026-10-08 10:01:26.001758 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2026-10-08 10:01:26.146991 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2026-10-08 10:01:26.31163 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2026-10-08 10:01:26.459661 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2026-10-08 10:01:26.623232 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2026-10-08 10:01:26.767316 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2026-10-08 10:01:26.933217 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2026-10-08 10:01:27.078021 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2026-10-08 10:01:27.246135 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2026-10-08 10:01:27.385189 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2026-10-08 10:01:27.556252 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2026-10-08 10:01:27.696695 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2026-10-08 10:01:27.865638 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2026-10-08 10:01:28.001284 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2026-10-08 10:01:28.173841 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2026-10-08 10:01:28.311409 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2026-10-08 10:01:28.480704 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2026-10-08 10:01:28.62136 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2026-10-08 10:01:28.831751 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2026-10-08 10:01:28.981003 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2026-10-08 10:01:29.14745 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2026-10-08 10:01:29.279429 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2026-10-08 10:01:29.484318 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2026-10-08 10:01:29.638418 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2026-10-08 10:01:29.791965 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2026-10-08 10:01:29.954573 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2026-10-08 10:01:30.093839 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2026-10-08 10:01:30.252691 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2026-10-08 10:01:30.391934 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2026-10-08 10:01:31.185886 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2026-10-08 10:01:31.302044 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2026-10-08 10:01:31.426287 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2026-10-08 10:01:31.545392 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2026-10-08 10:01:31.672721 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2026-10-08 10:01:31.793214 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2026-10-08 10:01:31.92295 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2026-10-08 10:01:32.04203 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2026-10-08 10:01:32.166924 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2026-10-08 10:01:32.292869 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2026-10-08 10:01:32.417114 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2026-10-08 10:01:32.556647 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2026-10-08 10:01:32.680777 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2026-10-08 10:01:32.810791 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2026-10-08 10:01:32.938426 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2026-10-08 10:01:33.071825 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2026-10-08 10:01:33.197496 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2026-10-08 10:01:33.334135 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2026-10-08 10:01:33.458408 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2026-10-08 10:01:33.587358 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2026-10-08 10:01:33.709092 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2026-10-08 10:01:33.839167 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2026-10-08 10:01:33.964618 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2026-10-08 10:01:34.100019 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2026-10-08 10:01:34.223338 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2026-10-08 10:01:34.356159 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2026-10-08 10:01:34.479667 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2026-10-08 10:01:34.670149 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2026-10-08 10:01:34.794677 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2026-10-08 10:01:34.923397 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2026-10-08 10:01:35.043008 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2026-10-08 10:01:35.175449 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2026-10-08 10:01:35.29692 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2026-10-08 10:01:35.429035 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2026-10-08 10:01:35.551795 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2026-10-08 10:01:35.681435 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2026-10-08 10:01:35.802968 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2026-10-08 10:01:35.931862 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2026-10-08 10:01:36.051041 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2026-10-08 10:01:36.181844 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2026-10-08 10:01:36.303273 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2026-10-08 10:01:36.438317 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2026-10-08 10:01:36.560442 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2026-10-08 10:01:36.756529 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2026-10-08 10:01:36.95531 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2026-10-08 10:01:37.097697 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2026-10-08 10:01:37.225468 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2026-10-08 10:01:37.341919 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2026-10-08 10:01:37.48274 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2026-10-08 10:01:37.603154 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2026-10-08 10:01:37.750994 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2026-10-08 10:01:37.873326 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2026-10-08 10:01:38.011337 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2026-10-08 10:01:38.13662 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2026-10-08 10:01:38.283603 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2026-10-08 10:01:38.412003 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2026-10-08 10:01:38.547392 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2026-10-08 10:01:38.676506 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2026-10-08 10:01:38.816334 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2026-10-08 10:01:38.942363 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2026-10-08 10:01:39.075696 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2026-10-08 10:01:39.209235 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2026-10-08 10:01:39.348926 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2026-10-08 10:01:39.494822 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2026-10-08 10:01:39.619555 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2026-10-08 10:01:39.770041 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2026-10-08 10:01:39.930747 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2026-10-08 10:01:40.077888 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2026-10-08 10:01:40.195371 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2026-10-08 10:01:40.334898 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2026-10-08 10:01:40.453532 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2026-10-08 10:01:40.599814 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2026-10-08 10:01:40.722192 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2026-10-08 10:01:40.864851 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2026-10-08 10:01:40.989195 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2026-10-08 10:01:41.134887 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2026-10-08 10:01:41.264055 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2026-10-08 10:01:41.414798 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2026-10-08 10:01:41.546439 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2026-10-08 10:01:41.697442 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2026-10-08 10:01:41.825145 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2026-10-08 10:01:41.978496 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2026-10-08 10:01:42.100775 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2026-10-08 10:01:42.245027 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2026-10-08 10:01:42.373171 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2026-10-08 10:01:42.512762 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2026-10-08 10:01:42.697319 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2026-10-08 10:01:42.841357 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2026-10-08 10:01:42.968776 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2026-10-08 10:01:43.131387 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2026-10-08 10:01:43.281496 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2026-10-08 10:01:43.445238 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2026-10-08 10:01:43.586903 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2026-10-08 10:01:43.747131 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2026-10-08 10:01:43.884907 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2026-10-08 10:01:44.047767 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2026-10-08 10:01:44.179377 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2026-10-08 10:01:44.333923 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2026-10-08 10:01:44.463983 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2026-10-08 10:01:44.666176 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2026-10-08 10:01:44.814428 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2026-10-08 10:01:44.947325 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2026-10-08 10:01:45.099604 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2026-10-08 10:01:45.225214 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2026-10-08 10:01:45.439423 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2026-10-08 10:01:45.576097 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2026-10-08 10:01:45.732668 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2026-10-08 10:01:45.862783 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2026-10-08 10:01:46.017537 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2026-10-08 10:01:46.150961 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2026-10-08 10:01:46.304415 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2026-10-08 10:01:46.433907 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2026-10-08 10:01:46.590541 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2026-10-08 10:01:46.720704 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2026-10-08 10:01:46.873158 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2026-10-08 10:01:47.00329 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2026-10-08 10:01:47.158411 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2026-10-08 10:01:47.295028 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2026-10-08 10:01:47.447994 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2026-10-08 10:01:47.581945 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2026-10-08 10:01:47.744714 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2026-10-08 10:01:47.883613 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2026-10-08 10:01:48.044502 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2026-10-08 10:01:48.183683 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2026-10-08 10:01:48.34546 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2026-10-08 10:01:48.480597 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2026-10-08 10:01:48.639126 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2026-10-08 10:01:48.773507 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2026-10-08 10:01:48.932862 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2026-10-08 10:01:49.067007 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2026-10-08 10:01:49.289237 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2026-10-08 10:01:49.427206 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2026-10-08 10:01:49.582796 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2026-10-08 10:01:49.71507 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2026-10-08 10:01:49.871996 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2026-10-08 10:01:50.006654 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2026-10-08 10:01:50.161615 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2026-10-08 10:01:50.290816 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2026-10-08 10:01:50.443318 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2026-10-08 10:01:50.575957 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2026-10-08 10:01:50.713437 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2026-10-08 10:01:50.863968 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2026-10-08 10:01:50.994483 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2026-10-08 10:01:51.151584 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2026-10-08 10:01:51.283016 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2026-10-08 10:01:51.442229 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2026-10-08 10:01:51.575277 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2026-10-08 10:01:51.734355 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2026-10-08 10:01:51.863058 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2026-10-08 10:01:52.061619 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2026-10-08 10:01:52.196209 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2026-10-08 10:01:52.351011 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2026-10-08 10:01:52.485284 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2026-10-08 10:01:52.645688 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2026-10-08 10:01:52.779866 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2026-10-08 10:01:52.934374 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2026-10-08 10:01:53.082543 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2026-10-08 10:01:53.240602 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2026-10-08 10:01:53.377964 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2026-10-08 10:01:53.534312 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2026-10-08 10:01:53.670082 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2026-10-08 10:01:53.82926 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2026-10-08 10:01:53.985099 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2026-10-08 10:01:54.14614 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2026-10-08 10:01:54.283895 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2026-10-08 10:01:54.437733 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2026-10-08 10:01:54.570425 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2026-10-08 10:01:54.723656 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2026-10-08 10:01:54.857057 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2026-10-08 10:01:55.010883 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2026-10-08 10:01:55.144574 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2026-10-08 10:01:55.297725 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2026-10-08 10:01:55.432729 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2026-10-08 10:01:55.653482 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2026-10-08 10:01:55.78806 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2026-10-08 10:01:56.008457 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2026-10-08 10:01:56.156131 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2026-10-08 10:01:56.323385 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2026-10-08 10:01:56.455832 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2026-10-08 10:01:56.616474 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2026-10-08 10:01:56.760373 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2026-10-08 10:01:56.908409 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2026-10-08 10:01:57.065607 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2026-10-08 10:01:57.200934 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2026-10-08 10:01:57.371276 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2026-10-08 10:01:57.506099 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2026-10-08 10:01:57.682136 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2026-10-08 10:01:57.822021 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2026-10-08 10:01:57.996614 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2026-10-08 10:01:58.132931 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2026-10-08 10:01:58.303293 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2026-10-08 10:01:58.440212 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2026-10-08 10:01:58.605897 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2026-10-08 10:01:58.739604 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2026-10-08 10:01:58.90708 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2026-10-08 10:01:59.041698 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2026-10-08 10:01:59.207443 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2026-10-08 10:01:59.343524 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2026-10-08 10:01:59.512589 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2026-10-08 10:01:59.647805 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2026-10-08 10:01:59.816297 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2026-10-08 10:01:59.952036 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2026-10-08 10:02:00.120177 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2026-10-08 10:02:00.265065 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2026-10-08 10:02:00.430532 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2026-10-08 10:02:00.566059 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2026-10-08 10:02:00.7343 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2026-10-08 10:02:00.873354 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2026-10-08 10:02:01.041349 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2026-10-08 10:02:01.175709 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2026-10-08 10:02:01.343356 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2026-10-08 10:02:01.478602 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2026-10-08 10:02:01.654598 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2026-10-08 10:02:01.790029 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2026-10-08 10:02:01.959985 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2026-10-08 10:02:02.096739 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2026-10-08 10:02:02.327905 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2026-10-08 10:02:02.467332 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2026-10-08 10:02:02.638392 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2026-10-08 10:02:02.773633 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2026-10-08 10:02:02.937362 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2026-10-08 10:02:03.073801 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2026-10-08 10:02:03.226321 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2026-10-08 10:02:03.377749 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2026-10-08 10:02:03.515363 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2026-10-08 10:02:03.684738 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2026-10-08 10:02:03.824933 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2026-10-08 10:02:04.006787 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2026-10-08 10:02:04.160415 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2026-10-08 10:02:04.337667 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2026-10-08 10:02:04.481526 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2026-10-08 10:02:04.657935 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2026-10-08 10:02:04.803859 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2026-10-08 10:02:04.975733 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2026-10-08 10:02:05.117411 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2026-10-08 10:02:05.291257 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2026-10-08 10:02:05.432854 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2026-10-08 10:02:05.610041 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2026-10-08 10:02:05.756389 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2026-10-08 10:02:05.936376 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2026-10-08 10:02:06.080493 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2026-10-08 10:02:06.253552 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2026-10-08 10:02:06.396418 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2026-10-08 10:02:06.569952 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2026-10-08 10:02:06.712312 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2026-10-08 10:02:06.88425 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2026-10-08 10:02:07.025307 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2026-10-08 10:02:07.196661 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2026-10-08 10:02:07.336932 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2026-10-08 10:02:07.505278 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2026-10-08 10:02:07.644492 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2026-10-08 10:02:07.820762 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2026-10-08 10:02:07.961305 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2026-10-08 10:02:08.130539 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2026-10-08 10:02:08.270078 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2026-10-08 10:02:08.44521 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2026-10-08 10:02:08.585145 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2026-10-08 10:02:08.792688 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2026-10-08 10:02:08.937312 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2026-10-08 10:02:09.770918 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2026-10-08 10:02:09.891123 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2026-10-08 10:02:10.01826 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2026-10-08 10:02:10.141432 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2026-10-08 10:02:10.267301 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2026-10-08 10:02:10.385215 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2026-10-08 10:02:10.5131 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2026-10-08 10:02:10.631285 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2026-10-08 10:02:10.755901 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2026-10-08 10:02:10.885633 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2026-10-08 10:02:11.010508 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2026-10-08 10:02:11.134515 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2026-10-08 10:02:11.257015 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2026-10-08 10:02:11.382075 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2026-10-08 10:02:11.500499 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2026-10-08 10:02:11.625469 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2026-10-08 10:02:11.74511 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2026-10-08 10:02:11.871925 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2026-10-08 10:02:11.993159 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2026-10-08 10:02:12.125586 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2026-10-08 10:02:12.250783 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2026-10-08 10:02:12.382869 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2026-10-08 10:02:12.509986 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2026-10-08 10:02:12.646722 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2026-10-08 10:02:12.769392 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2026-10-08 10:02:12.903537 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2026-10-08 10:02:13.027457 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2026-10-08 10:02:13.159284 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2026-10-08 10:02:13.290746 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2026-10-08 10:02:13.418767 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2026-10-08 10:02:13.549451 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2026-10-08 10:02:13.677047 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2026-10-08 10:02:13.811692 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2026-10-08 10:02:13.941228 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2026-10-08 10:02:14.069641 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2026-10-08 10:02:14.197801 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2026-10-08 10:02:14.32703 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2026-10-08 10:02:14.456696 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2026-10-08 10:02:14.603595 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2026-10-08 10:02:14.731397 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2026-10-08 10:02:14.863609 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2026-10-08 10:02:14.987951 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2026-10-08 10:02:15.114733 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2026-10-08 10:02:15.301912 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2026-10-08 10:02:15.438847 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2026-10-08 10:02:15.56535 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2026-10-08 10:02:15.708588 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2026-10-08 10:02:15.828865 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2026-10-08 10:02:15.968888 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2026-10-08 10:02:16.093103 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2026-10-08 10:02:16.231772 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2026-10-08 10:02:16.362032 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2026-10-08 10:02:16.498368 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2026-10-08 10:02:16.629687 INFO::Creating boxplot for categorical data, antibiotics vs F367
## 2026-10-08 10:02:17.917382 INFO::Plotting data for metadata number 3, age
## 2026-10-08 10:02:17.918522 INFO::Creating scatter plot for continuous data, age vs F340
## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.
## ℹ The deprecated feature was likely used in the Maaslin2 package.
##   Please report the issue at <https://github.com/biobakery/maaslin2/issues>.
## This warning is displayed once per session.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:18.084401 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:18.266891 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:18.403214 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:18.534926 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:18.670117 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:18.80222 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:18.932866 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:19.068574 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:19.178275 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:19.320112 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:19.439208 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:19.580279 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:19.702715 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:19.84867 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:19.962003 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:20.100473 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:20.22092 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:20.365447 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:20.493647 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:20.623924 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:20.751005 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:20.885359 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:21.013039 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:21.147234 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:21.344681 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:21.470289 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:21.592303 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:21.743234 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:21.872934 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:22.013051 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:22.131869 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:22.280327 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:22.406587 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:22.558511 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:22.692378 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:22.843449 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:22.974525 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:23.126553 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:23.265978 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:23.416683 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:23.544915 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:23.698015 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:23.825631 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:23.978921 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:24.117104 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:24.270109 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:24.396366 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:24.544412 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:24.674327 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:24.822209 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:24.954736 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:25.096535 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:25.219463 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:25.366358 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:25.489426 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:25.638239 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:25.764563 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:25.963357 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:26.093657 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:26.237052 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:26.364551 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:26.513675 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:26.630606 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:26.841846 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:26.994579 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:27.138366 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:27.351328 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:27.482148 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:27.638021 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:27.769489 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:27.898458 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:28.050695 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:28.184376 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:28.340491 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:28.462478 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:28.607507 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:28.731982 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:28.879507 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:29.012482 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:29.165915 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:29.296934 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:29.451566 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:29.586087 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:29.735384 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:29.863717 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:30.011042 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:30.147636 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:30.292463 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:30.42285 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:30.567653 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:30.701291 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:30.846667 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:30.971386 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:31.126684 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:31.260104 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:31.412693 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:31.550695 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:31.707549 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:31.83681 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:31.997227 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:32.126557 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:32.281839 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:32.408516 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:32.567038 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:32.694559 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:32.841867 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:32.98416 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:33.119179 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:33.336691 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:33.476651 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:33.613102 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:33.770102 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:33.902084 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:34.070821 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:34.207208 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:34.375647 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:34.503731 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:34.660919 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:34.79007 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:34.962096 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:35.098658 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:35.272928 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:35.402117 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:35.571564 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:35.698427 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:35.868851 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:35.995146 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:36.155982 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:36.284888 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:36.43878 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:36.57857 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:36.745475 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:36.87796 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:37.035481 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:37.163875 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:37.332719 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:37.458962 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:37.620232 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:37.755668 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:37.92798 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:38.064961 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:38.230955 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:38.359184 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:38.529301 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:38.662632 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:38.830053 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:38.972828 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:39.122757 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:39.280903 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:39.429854 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:39.666972 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:39.798583 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:39.972692 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:40.101032 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:40.260883 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:40.400503 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## 2026-10-08 10:02:40.538029 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:40.706272 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:40.838097 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:41.014863 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:41.160819 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2026-10-08 10:02:41.364367 INFO::Creating scatter plot for continuous data, age vs F393
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## Initiating effect size calculations
## Calculating mean abundance in: IBD
## Calculating mean abundance in: Control
## Calculating effect size in: IBD
## Initiating prioritization
## Calculating meta-rank and prioritizing metabolic features
## 2026-10-08 10:02:42.876188 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2026-10-08 10:02:42.879689 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2026-10-08 10:02:42.889096 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv

Using dataframes as inputs

abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames 
taxonomy_df = read.csv(file = mets_taxonomy)

# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df)

Running Macarron as individual functions

The Macarron::Macarron() function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:

# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
                       input_annotations = annotations_df,
                       input_metadata = metadata_df)

# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)

# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]

# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
                    mod.assn = prism_modules)

# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules)

# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
                   mac.qval = prism_qval)

# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
                                mod.assn = prism_modules,
                                mac.ava = prism_ava,
                                mac.qval = prism_qval,
                                mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]

# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)

Session info from running the demo in R can be displayed with the following command.

sessionInfo()
## R version 4.6.1 (2026-06-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 26.04.1 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.32.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] Macarron_1.16.0             SummarizedExperiment_1.42.0
##  [3] Biobase_2.72.0              GenomicRanges_1.64.0       
##  [5] Seqinfo_1.2.0               IRanges_2.46.0             
##  [7] S4Vectors_0.50.3            BiocGenerics_0.58.1        
##  [9] generics_0.1.4              MatrixGenerics_1.24.0      
## [11] matrixStats_1.5.0           BiocStyle_2.40.0           
## 
## loaded via a namespace (and not attached):
##  [1] mnormt_2.1.2          DBI_1.3.0             pbapply_1.7-5        
##  [4] gridExtra_2.3.1       rlang_1.3.0           magrittr_2.0.5       
##  [7] otel_0.2.0            compiler_4.6.1        mgcv_1.9-4           
## [10] vctrs_0.7.3           stringr_1.6.0         pkgconfig_2.0.3      
## [13] crayon_1.5.3          fastmap_1.2.0         backports_1.5.1      
## [16] XVector_0.52.0        labeling_0.4.3        rmarkdown_2.32       
## [19] preprocessCore_1.74.0 xfun_0.61             cachem_1.1.0         
## [22] jsonlite_2.0.0        DelayedArray_0.38.2   BiocParallel_1.46.0  
## [25] psych_2.6.9           parallel_4.6.1        Maaslin2_1.26.0      
## [28] cluster_2.1.8.3       R6_2.6.1              biglm_0.9-3          
## [31] bslib_0.12.0          stringi_1.8.9         RColorBrewer_1.1-3   
## [34] rpart_4.1.27          jquerylib_0.1.4       Rcpp_1.1.2           
## [37] iterators_1.0.14      knitr_1.52            WGCNA_1.74           
## [40] base64enc_0.1-6       Matrix_1.7-6          splines_4.6.1        
## [43] nnet_7.3-21           tidyselect_1.2.1      rstudioapi_0.19.0    
## [46] abind_1.4-8           yaml_2.3.12           doParallel_1.0.17    
## [49] codetools_0.2-20      plyr_1.8.9            lattice_0.23-1       
## [52] tibble_3.3.1          withr_3.0.3           S7_0.2.2             
## [55] evaluate_1.0.5        foreign_0.8-91        survival_3.8-12      
## [58] pillar_1.11.1         BiocManager_1.30.27   checkmate_2.3.4      
## [61] foreach_1.5.2         pcaPP_2.0-7           ggplot2_4.0.3        
## [64] scales_1.4.0          glue_1.8.1            Hmisc_5.3-0          
## [67] maketools_1.3.2       tools_4.6.1           robustbase_0.99-7    
## [70] sys_3.4.3             data.table_1.18.6.1   buildtools_1.0.0     
## [73] mvtnorm_1.4-2         fastcluster_1.3.0     grid_4.6.1           
## [76] impute_1.86.0         optparse_1.8.2        colorspace_2.1-3     
## [79] nlme_3.1-171          htmlTable_2.5.0       Formula_1.2-6        
## [82] cli_3.6.6             S4Arrays_1.12.1       dplyr_1.2.1          
## [85] gtable_0.3.6          DEoptimR_1.2-2        logging_0.10-111     
## [88] dynamicTreeCut_1.63-1 hash_2.2.6.4          sass_0.4.10          
## [91] digest_0.6.39         SparseArray_1.12.3    htmlwidgets_1.6.4    
## [94] farver_2.1.2          htmltools_0.5.9       lifecycle_1.0.5

Advanced Topics

Generating the input chemical taxonomy file

The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID(). This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.

prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
annotations_df <- read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
taxonomy_df <- decorateID(input_annotations = annotations_df)

Accessory output files

Macarron.log

A record of all chosen parameters and steps that were followed during execution.

modules_measures_of_success.csv

This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:

  • Total modules: Number of modules.
  • Singletons: Number of metabolic features that were not assigned to any module at MMS.
  • % Annotated modules: Percentage of modules that contained at least one annotated metabolic feature.
  • % Consistent assignments: Percentage of times the same metabolic feature was assigned to the same module e.g. if three metabolic features represent glucose, they should all be in the same module. This percentage must be high.
  • Max classes per module: The highest number of chemical classes observed in any module. This is evaluated using the chemical taxonomy of covarying annotated features.
  • 90p classes per module: 90th percentile of classes per module; captures the chemical homogeneity of the modules.
  • Max subclasses per module: The highest number of chemical subclasses observed in any module.
  • 90p subclasses per module: 90th percentile of subclasses per module; captures the chemical homogeneity of the modules.
  • % Features in HAM: Macarron first finds homogeneously annoted modules (HAMs): These are modules in which >75% annotated features have the same chemical class indicating that they are chemically homogeneous. It then calculates how many features the HAMs account for.

Maaslin2 results

This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.

Changing defaults

Filtering metabolic features based on prevalence

Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence argument.

prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df,
                                        min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
                      min_prevalence = 0.5)

Minimum module size

By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA and dynamicTreeCut.

# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)

# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df,
                            min_module_size = 10)

Specifying fixed effects, random effects and reference

Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories. Defaults can be changed with the arguments fixed_effects, random_effects and reference. In the demo example, fixed effects and reference can be defined as follows:

prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules,
                      metadata_variable = "diagnosis",
                      fixed_effects = c("diagnosis","age","antibiotics"),
                      reference = c("diagnosis,Control";"antibiotics,No"))

Command line invocation

The package source contains a script MacarronCMD.R in inst/scripts to invoke Macarron in the command line using Rscript. The inst/scripts folder also contains a README file that comprehensively documents the usage of the script.