Abstract

Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.

If you have questions, please direct it to: Macarron Forum

Installation

Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:

if(!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("Macarron")

Running Macarron

Macarron can be run from the command line or as an R function. Both methods require the same arguments, have the same options, and use the same default settings. The package includes the wrapper Macarron() as well as functions which perform different steps in the Macarron framework.

Input CSV files

Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.

Metabolic features abundances
- Must contain features in rows and samples in columns.
- First column must identify features.
Metabolic features annotations
- Must contain features in rows and annotations in columns.
- First column must identify features.
- Second column must contain either HMDB ID or PubChem Compound Identifier (CID).
- Third column must contain the name of the metabolite.
- Fourth column must contain a continuous chemical property such as m/z or RT or shift/ppm.
- Other annotations such as RT, m/z or other identifiers can be listed column 4 onward.
Sample metadata
- Must contain samples in rows and metadata in columns.
- First column must identify samples.
- Second column must contain categorical metadata relevant to prioritization such as phenotypes, exposures or environments.
Chemical taxonomy
- First column must contain the HMDB ID or PubChem CID. IDs must be consistent between annotation and taxonomy files.
- Second and third columns must contain chemical subclass and class of the respective metabolite.

If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID (see Advanced Topics).

Output Files

By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv. Another file, prioritized_metabolites_characterizable.csv is a subset of prioritized_metabolites_all.csv and only contains metabolic features which covary with at least one annotated metabolite. The columns in these output files are:

Feature_index: Lists the identifier of the metabolic feature found in column 1 of abundance and annotation files.
HMDB_ID (or PubChem ID): Public database identifier from column 2 of annotation file (column 1 of annotation dataframe).
Metabolite name: From column 2 of annotation dataframe.
mz: The continuous numerical chemical property from column 3 of the annotation dataframe.
Priority_score: 1 indicates most prioritized. It is the percentile from the meta-rank of AVA, q-value and effect size.
Status: Direction of perturbation (differential abundance) in the phenotype (or environment) of interest compared to reference phenotype.
Module: ID of the covariance module a metabolic feature is a member of. Module = 0 indicates a singleton i.e., a metabolic feature that is not assigned to any module.
Anchor (of a module): Metabolic feature that has the highest abundance in any phenotype.
Related_classes: Chemical taxonomy of the annotated features that covary with a metabolic feature.
Covaries_with_standard: 1 (yes) and 0 (no). Column specifies if the metabolic feature covaries with at least one annotated (standard) metabolite.
AVA: Abundance versus anchor which is a ratio of the highest abundance (in any phenotype) of a metabolic feature and highest abundance of the covarying anchor. Naturally, the AVA of an anchor metabolite is 1.
qvalue: Estimated from multivariate linear model using Maaslin2.
effect_size
Remaining columns from the annotation dataframe are appended.

Run a demo in R

Using CSV files as inputs

Example (demo) input files can be found under inst/extdata folder of the Macarron source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv, demo_annotations.csv, demo_metadata.csv, and demo_taxonomy.csv.

library(Macarron)

## Loading required package: SummarizedExperiment

## Loading required package: MatrixGenerics

## Loading required package: matrixStats

## 
## Attaching package: 'MatrixGenerics'

## The following objects are masked from 'package:matrixStats':
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##     colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats,
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## Attaching package: 'Biobase'

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prism_abundances <- system.file(
    'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
    'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
    'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
                                        input_annotations = prism_annotations,
                                        input_metadata = prism_metadata,
                                        input_taxonomy = mets_taxonomy)

## 2026-05-31 06:37:31.820243 INFO::Creating output folder.
## 2026-05-31 06:37:31.828075 INFO::Writing function arguments to log file

## Samples with both abundances and metadata: 102

## 2026-05-31 06:37:31.869095 INFO::Summarized Experiment created.
## 2026-05-31 06:37:31.870291 INFO::Metadata chosen for prevalence filtering: diagnosis

## 869 features pass chosen minimum prevalence threshold of 0.7.

## Calculating pairwise correlations in phenotype: IBD

## Calculating pairwise correlations in phenotype: Control

## Distance matrix with 869 features created.

## 2026-05-31 06:37:34.674675 INFO::Distance matrix with 869 metabolic features created.

## Initiating module detection

## 2026-05-31 06:37:34.675684 INFO::Minimum module size used for this dataset: 10

## Tree constructed

## Evaluating measures of success

##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
## 2026-05-31 06:37:35.650991 INFO::Total number of modules detected: 30

## Initiating AVA calculations

## Finding anchors

## Calculating AVA

## Initiating q-value calculations

## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2026-05-31 06:37:36.917669 INFO::Writing function arguments to log file
## 2026-05-31 06:37:36.921448 INFO::Verifying options selected are valid
## 2026-05-31 06:37:36.94634 INFO::Determining format of input files
## 2026-05-31 06:37:36.947056 INFO::Input format is data samples as columns and metadata samples as rows
## 2026-05-31 06:37:36.958355 INFO::Formula for fixed effects: expr ~  diagnosis + age + antibiotics
## 2026-05-31 06:37:36.959342 INFO::Filter data based on min abundance and min prevalence
## 2026-05-31 06:37:36.959783 INFO::Total samples in data: 102
## 2026-05-31 06:37:36.960204 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2026-05-31 06:37:36.968412 INFO::Total filtered features: 0
## 2026-05-31 06:37:36.969032 INFO::Filtered feature names from abundance and prevalence filtering:
## 2026-05-31 06:37:36.984255 INFO::Total filtered features with variance filtering: 10
## 2026-05-31 06:37:36.984941 INFO::Filtered feature names from variance filtering: F1, F59, F74, F416, F577, F629, F672, F744, F754, F846
## 2026-05-31 06:37:36.985404 INFO::Running selected normalization method: NONE
## 2026-05-31 06:37:36.985853 INFO::Applying z-score to standardize continuous metadata
## 2026-05-31 06:37:36.999835 INFO::Running selected transform method: NONE
## 2026-05-31 06:37:37.000438 INFO::Running selected analysis method: LM
## 2026-05-31 06:37:37.004087 INFO::Fitting model to feature number 1, F2
## 2026-05-31 06:37:37.010801 INFO::Fitting model to feature number 2, F3
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## 2026-05-31 06:37:37.38637 INFO::Fitting model to feature number 160, F169
## 2026-05-31 06:37:37.388572 INFO::Fitting model to feature number 161, F170
## 2026-05-31 06:37:37.390749 INFO::Fitting model to feature number 162, F171
## 2026-05-31 06:37:37.392944 INFO::Fitting model to feature number 163, F172
## 2026-05-31 06:37:37.395159 INFO::Fitting model to feature number 164, F173
## 2026-05-31 06:37:37.397364 INFO::Fitting model to feature number 165, F174
## 2026-05-31 06:37:37.39959 INFO::Fitting model to feature number 166, F175
## 2026-05-31 06:37:37.401841 INFO::Fitting model to feature number 167, F176
## 2026-05-31 06:37:37.404078 INFO::Fitting model to feature number 168, F177
## 2026-05-31 06:37:37.406311 INFO::Fitting model to feature number 169, F178
## 2026-05-31 06:37:37.4085 INFO::Fitting model to feature number 170, F179
## 2026-05-31 06:37:37.410679 INFO::Fitting model to feature number 171, F180
## 2026-05-31 06:37:37.412866 INFO::Fitting model to feature number 172, F181
## 2026-05-31 06:37:37.415047 INFO::Fitting model to feature number 173, F182
## 2026-05-31 06:37:37.417351 INFO::Fitting model to feature number 174, F183
## 2026-05-31 06:37:37.419578 INFO::Fitting model to feature number 175, F184
## 2026-05-31 06:37:37.42178 INFO::Fitting model to feature number 176, F185
## 2026-05-31 06:37:37.423996 INFO::Fitting model to feature number 177, F186
## 2026-05-31 06:37:37.426204 INFO::Fitting model to feature number 178, F187
## 2026-05-31 06:37:37.428566 INFO::Fitting model to feature number 179, F188
## 2026-05-31 06:37:37.430775 INFO::Fitting model to feature number 180, F189
## 2026-05-31 06:37:37.432991 INFO::Fitting model to feature number 181, F190
## 2026-05-31 06:37:37.435206 INFO::Fitting model to feature number 182, F191
## 2026-05-31 06:37:37.437387 INFO::Fitting model to feature number 183, F192
## 2026-05-31 06:37:37.439559 INFO::Fitting model to feature number 184, F193
## 2026-05-31 06:37:37.441769 INFO::Fitting model to feature number 185, F194
## 2026-05-31 06:37:37.443995 INFO::Fitting model to feature number 186, F195
## 2026-05-31 06:37:37.446219 INFO::Fitting model to feature number 187, F196
## 2026-05-31 06:37:37.448443 INFO::Fitting model to feature number 188, F197
## 2026-05-31 06:37:37.450662 INFO::Fitting model to feature number 189, F198
## 2026-05-31 06:37:37.452875 INFO::Fitting model to feature number 190, F199
## 2026-05-31 06:37:37.455083 INFO::Fitting model to feature number 191, F200
## 2026-05-31 06:37:37.457309 INFO::Fitting model to feature number 192, F201
## 2026-05-31 06:37:37.459514 INFO::Fitting model to feature number 193, F202
## 2026-05-31 06:37:37.461731 INFO::Fitting model to feature number 194, F203
## 2026-05-31 06:37:37.463937 INFO::Fitting model to feature number 195, F204
## 2026-05-31 06:37:37.466161 INFO::Fitting model to feature number 196, F206
## 2026-05-31 06:37:37.468349 INFO::Fitting model to feature number 197, F207
## 2026-05-31 06:37:37.470544 INFO::Fitting model to feature number 198, F208
## 2026-05-31 06:37:37.472765 INFO::Fitting model to feature number 199, F209
## 2026-05-31 06:37:37.474959 INFO::Fitting model to feature number 200, F210
## 2026-05-31 06:37:37.477174 INFO::Fitting model to feature number 201, F211
## 2026-05-31 06:37:37.479377 INFO::Fitting model to feature number 202, F212
## 2026-05-31 06:37:37.481565 INFO::Fitting model to feature number 203, F213
## 2026-05-31 06:37:37.483781 INFO::Fitting model to feature number 204, F214
## 2026-05-31 06:37:37.485994 INFO::Fitting model to feature number 205, F215
## 2026-05-31 06:37:37.488294 INFO::Fitting model to feature number 206, F216
## 2026-05-31 06:37:37.490477 INFO::Fitting model to feature number 207, F217
## 2026-05-31 06:37:37.492666 INFO::Fitting model to feature number 208, F218
## 2026-05-31 06:37:37.494877 INFO::Fitting model to feature number 209, F219
## 2026-05-31 06:37:37.497085 INFO::Fitting model to feature number 210, F220
## 2026-05-31 06:37:37.499286 INFO::Fitting model to feature number 211, F221
## 2026-05-31 06:37:37.501481 INFO::Fitting model to feature number 212, F222
## 2026-05-31 06:37:37.503716 INFO::Fitting model to feature number 213, F223
## 2026-05-31 06:37:37.505918 INFO::Fitting model to feature number 214, F224
## 2026-05-31 06:37:37.508131 INFO::Fitting model to feature number 215, F225
## 2026-05-31 06:37:37.510324 INFO::Fitting model to feature number 216, F226
## 2026-05-31 06:37:37.512531 INFO::Fitting model to feature number 217, F227
## 2026-05-31 06:37:37.514717 INFO::Fitting model to feature number 218, F228
## 2026-05-31 06:37:37.516928 INFO::Fitting model to feature number 219, F229
## 2026-05-31 06:37:37.519146 INFO::Fitting model to feature number 220, F230
## 2026-05-31 06:37:37.521353 INFO::Fitting model to feature number 221, F231
## 2026-05-31 06:37:37.523561 INFO::Fitting model to feature number 222, F232
## 2026-05-31 06:37:37.525762 INFO::Fitting model to feature number 223, F233
## 2026-05-31 06:37:37.527998 INFO::Fitting model to feature number 224, F234
## 2026-05-31 06:37:37.530201 INFO::Fitting model to feature number 225, F235
## 2026-05-31 06:37:37.532427 INFO::Fitting model to feature number 226, F236
## 2026-05-31 06:37:37.534627 INFO::Fitting model to feature number 227, F237
## 2026-05-31 06:37:37.536822 INFO::Fitting model to feature number 228, F238
## 2026-05-31 06:37:37.538991 INFO::Fitting model to feature number 229, F239
## 2026-05-31 06:37:37.541215 INFO::Fitting model to feature number 230, F240
## 2026-05-31 06:37:37.543425 INFO::Fitting model to feature number 231, F241
## 2026-05-31 06:37:37.545638 INFO::Fitting model to feature number 232, F242
## 2026-05-31 06:37:37.547827 INFO::Fitting model to feature number 233, F243
## 2026-05-31 06:37:37.550031 INFO::Fitting model to feature number 234, F244
## 2026-05-31 06:37:37.552263 INFO::Fitting model to feature number 235, F245
## 2026-05-31 06:37:37.554456 INFO::Fitting model to feature number 236, F246
## 2026-05-31 06:37:37.556665 INFO::Fitting model to feature number 237, F247
## 2026-05-31 06:37:37.55885 INFO::Fitting model to feature number 238, F248
## 2026-05-31 06:37:37.561052 INFO::Fitting model to feature number 239, F249
## 2026-05-31 06:37:37.56329 INFO::Fitting model to feature number 240, F250
## 2026-05-31 06:37:37.565482 INFO::Fitting model to feature number 241, F252
## 2026-05-31 06:37:37.567691 INFO::Fitting model to feature number 242, F253
## 2026-05-31 06:37:37.569894 INFO::Fitting model to feature number 243, F254
## 2026-05-31 06:37:37.57213 INFO::Fitting model to feature number 244, F255
## 2026-05-31 06:37:37.574351 INFO::Fitting model to feature number 245, F256
## 2026-05-31 06:37:37.576553 INFO::Fitting model to feature number 246, F257
## 2026-05-31 06:37:37.578754 INFO::Fitting model to feature number 247, F259
## 2026-05-31 06:37:37.580957 INFO::Fitting model to feature number 248, F260
## 2026-05-31 06:37:37.583173 INFO::Fitting model to feature number 249, F261
## 2026-05-31 06:37:37.58536 INFO::Fitting model to feature number 250, F262
## 2026-05-31 06:37:37.587555 INFO::Fitting model to feature number 251, F263
## 2026-05-31 06:37:37.589752 INFO::Fitting model to feature number 252, F264
## 2026-05-31 06:37:37.591948 INFO::Fitting model to feature number 253, F265
## 2026-05-31 06:37:37.594183 INFO::Fitting model to feature number 254, F266
## 2026-05-31 06:37:37.596389 INFO::Fitting model to feature number 255, F267
## 2026-05-31 06:37:37.598571 INFO::Fitting model to feature number 256, F269
## 2026-05-31 06:37:37.600765 INFO::Fitting model to feature number 257, F270
## 2026-05-31 06:37:37.602962 INFO::Fitting model to feature number 258, F271
## 2026-05-31 06:37:37.605263 INFO::Fitting model to feature number 259, F272
## 2026-05-31 06:37:37.607452 INFO::Fitting model to feature number 260, F273
## 2026-05-31 06:37:37.609643 INFO::Fitting model to feature number 261, F274
## 2026-05-31 06:37:37.611827 INFO::Fitting model to feature number 262, F276
## 2026-05-31 06:37:37.614031 INFO::Fitting model to feature number 263, F277
## 2026-05-31 06:37:37.61629 INFO::Fitting model to feature number 264, F278
## 2026-05-31 06:37:37.618491 INFO::Fitting model to feature number 265, F279
## 2026-05-31 06:37:37.620692 INFO::Fitting model to feature number 266, F280
## 2026-05-31 06:37:37.622912 INFO::Fitting model to feature number 267, F281
## 2026-05-31 06:37:37.625146 INFO::Fitting model to feature number 268, F282
## 2026-05-31 06:37:37.627345 INFO::Fitting model to feature number 269, F283
## 2026-05-31 06:37:37.629548 INFO::Fitting model to feature number 270, F284
## 2026-05-31 06:37:37.631742 INFO::Fitting model to feature number 271, F285
## 2026-05-31 06:37:37.633945 INFO::Fitting model to feature number 272, F286
## 2026-05-31 06:37:37.636141 INFO::Fitting model to feature number 273, F287
## 2026-05-31 06:37:37.638334 INFO::Fitting model to feature number 274, F288
## 2026-05-31 06:37:37.64054 INFO::Fitting model to feature number 275, F289
## 2026-05-31 06:37:37.642748 INFO::Fitting model to feature number 276, F290
## 2026-05-31 06:37:37.644953 INFO::Fitting model to feature number 277, F292
## 2026-05-31 06:37:37.647184 INFO::Fitting model to feature number 278, F293
## 2026-05-31 06:37:37.649397 INFO::Fitting model to feature number 279, F294
## 2026-05-31 06:37:37.651612 INFO::Fitting model to feature number 280, F295
## 2026-05-31 06:37:37.653805 INFO::Fitting model to feature number 281, F296
## 2026-05-31 06:37:37.656011 INFO::Fitting model to feature number 282, F297
## 2026-05-31 06:37:37.658254 INFO::Fitting model to feature number 283, F298
## 2026-05-31 06:37:37.660446 INFO::Fitting model to feature number 284, F299
## 2026-05-31 06:37:37.662646 INFO::Fitting model to feature number 285, F300
## 2026-05-31 06:37:37.664857 INFO::Fitting model to feature number 286, F301
## 2026-05-31 06:37:37.667082 INFO::Fitting model to feature number 287, F302
## 2026-05-31 06:37:37.669301 INFO::Fitting model to feature number 288, F303
## 2026-05-31 06:37:37.671506 INFO::Fitting model to feature number 289, F304
## 2026-05-31 06:37:37.673707 INFO::Fitting model to feature number 290, F305
## 2026-05-31 06:37:37.675893 INFO::Fitting model to feature number 291, F306
## 2026-05-31 06:37:37.678104 INFO::Fitting model to feature number 292, F307
## 2026-05-31 06:37:37.680329 INFO::Fitting model to feature number 293, F308
## 2026-05-31 06:37:37.682542 INFO::Fitting model to feature number 294, F309
## 2026-05-31 06:37:37.684747 INFO::Fitting model to feature number 295, F310
## 2026-05-31 06:37:37.686941 INFO::Fitting model to feature number 296, F311
## 2026-05-31 06:37:37.689158 INFO::Fitting model to feature number 297, F312
## 2026-05-31 06:37:37.691374 INFO::Fitting model to feature number 298, F313
## 2026-05-31 06:37:37.693559 INFO::Fitting model to feature number 299, F315
## 2026-05-31 06:37:37.695832 INFO::Fitting model to feature number 300, F316
## 2026-05-31 06:37:37.69804 INFO::Fitting model to feature number 301, F317
## 2026-05-31 06:37:37.700291 INFO::Fitting model to feature number 302, F318
## 2026-05-31 06:37:37.702487 INFO::Fitting model to feature number 303, F319
## 2026-05-31 06:37:37.704973 INFO::Fitting model to feature number 304, F320
## 2026-05-31 06:37:37.70731 INFO::Fitting model to feature number 305, F321
## 2026-05-31 06:37:37.709654 INFO::Fitting model to feature number 306, F322
## 2026-05-31 06:37:37.712028 INFO::Fitting model to feature number 307, F323
## 2026-05-31 06:37:37.714396 INFO::Fitting model to feature number 308, F324
## 2026-05-31 06:37:37.716693 INFO::Fitting model to feature number 309, F325
## 2026-05-31 06:37:37.719153 INFO::Fitting model to feature number 310, F326
## 2026-05-31 06:37:37.734987 INFO::Fitting model to feature number 311, F327
## 2026-05-31 06:37:37.737297 INFO::Fitting model to feature number 312, F328
## 2026-05-31 06:37:37.739496 INFO::Fitting model to feature number 313, F329
## 2026-05-31 06:37:37.741693 INFO::Fitting model to feature number 314, F330
## 2026-05-31 06:37:37.743891 INFO::Fitting model to feature number 315, F331
## 2026-05-31 06:37:37.746102 INFO::Fitting model to feature number 316, F332
## 2026-05-31 06:37:37.748295 INFO::Fitting model to feature number 317, F333
## 2026-05-31 06:37:37.750475 INFO::Fitting model to feature number 318, F334
## 2026-05-31 06:37:37.75267 INFO::Fitting model to feature number 319, F335
## 2026-05-31 06:37:37.754863 INFO::Fitting model to feature number 320, F336
## 2026-05-31 06:37:37.757045 INFO::Fitting model to feature number 321, F337
## 2026-05-31 06:37:37.759295 INFO::Fitting model to feature number 322, F338
## 2026-05-31 06:37:37.761512 INFO::Fitting model to feature number 323, F339
## 2026-05-31 06:37:37.763806 INFO::Fitting model to feature number 324, F340
## 2026-05-31 06:37:37.766026 INFO::Fitting model to feature number 325, F342
## 2026-05-31 06:37:37.768245 INFO::Fitting model to feature number 326, F343
## 2026-05-31 06:37:37.770421 INFO::Fitting model to feature number 327, F344
## 2026-05-31 06:37:37.772704 INFO::Fitting model to feature number 328, F345
## 2026-05-31 06:37:37.774965 INFO::Fitting model to feature number 329, F346
## 2026-05-31 06:37:37.777178 INFO::Fitting model to feature number 330, F347
## 2026-05-31 06:37:37.779384 INFO::Fitting model to feature number 331, F348
## 2026-05-31 06:37:37.781567 INFO::Fitting model to feature number 332, F350
## 2026-05-31 06:37:37.783818 INFO::Fitting model to feature number 333, F351
## 2026-05-31 06:37:37.786055 INFO::Fitting model to feature number 334, F352
## 2026-05-31 06:37:37.788412 INFO::Fitting model to feature number 335, F353
## 2026-05-31 06:37:37.790609 INFO::Fitting model to feature number 336, F355
## 2026-05-31 06:37:37.792922 INFO::Fitting model to feature number 337, F356
## 2026-05-31 06:37:37.795269 INFO::Fitting model to feature number 338, F357
## 2026-05-31 06:37:37.797501 INFO::Fitting model to feature number 339, F358
## 2026-05-31 06:37:37.799723 INFO::Fitting model to feature number 340, F359
## 2026-05-31 06:37:37.801982 INFO::Fitting model to feature number 341, F360
## 2026-05-31 06:37:37.80425 INFO::Fitting model to feature number 342, F361
## 2026-05-31 06:37:37.80663 INFO::Fitting model to feature number 343, F362
## 2026-05-31 06:37:37.809027 INFO::Fitting model to feature number 344, F363
## 2026-05-31 06:37:37.811295 INFO::Fitting model to feature number 345, F364
## 2026-05-31 06:37:37.813553 INFO::Fitting model to feature number 346, F365
## 2026-05-31 06:37:37.815743 INFO::Fitting model to feature number 347, F366
## 2026-05-31 06:37:37.81794 INFO::Fitting model to feature number 348, F367
## 2026-05-31 06:37:37.820168 INFO::Fitting model to feature number 349, F368
## 2026-05-31 06:37:37.822364 INFO::Fitting model to feature number 350, F369
## 2026-05-31 06:37:37.824551 INFO::Fitting model to feature number 351, F370
## 2026-05-31 06:37:37.826759 INFO::Fitting model to feature number 352, F371
## 2026-05-31 06:37:37.828983 INFO::Fitting model to feature number 353, F372
## 2026-05-31 06:37:37.831212 INFO::Fitting model to feature number 354, F373
## 2026-05-31 06:37:37.83341 INFO::Fitting model to feature number 355, F374
## 2026-05-31 06:37:37.835606 INFO::Fitting model to feature number 356, F375
## 2026-05-31 06:37:37.837821 INFO::Fitting model to feature number 357, F376
## 2026-05-31 06:37:37.840019 INFO::Fitting model to feature number 358, F377
## 2026-05-31 06:37:37.842232 INFO::Fitting model to feature number 359, F378
## 2026-05-31 06:37:37.844418 INFO::Fitting model to feature number 360, F379
## 2026-05-31 06:37:37.846616 INFO::Fitting model to feature number 361, F380
## 2026-05-31 06:37:37.848818 INFO::Fitting model to feature number 362, F381
## 2026-05-31 06:37:37.851006 INFO::Fitting model to feature number 363, F382
## 2026-05-31 06:37:37.853229 INFO::Fitting model to feature number 364, F383
## 2026-05-31 06:37:37.855412 INFO::Fitting model to feature number 365, F384
## 2026-05-31 06:37:37.857599 INFO::Fitting model to feature number 366, F386
## 2026-05-31 06:37:37.859782 INFO::Fitting model to feature number 367, F387
## 2026-05-31 06:37:37.862051 INFO::Fitting model to feature number 368, F388
## 2026-05-31 06:37:37.864308 INFO::Fitting model to feature number 369, F389
## 2026-05-31 06:37:37.866528 INFO::Fitting model to feature number 370, F390
## 2026-05-31 06:37:37.868769 INFO::Fitting model to feature number 371, F391
## 2026-05-31 06:37:37.871042 INFO::Fitting model to feature number 372, F392
## 2026-05-31 06:37:37.873343 INFO::Fitting model to feature number 373, F393
## 2026-05-31 06:37:37.875576 INFO::Fitting model to feature number 374, F394
## 2026-05-31 06:37:37.877798 INFO::Fitting model to feature number 375, F395
## 2026-05-31 06:37:37.880014 INFO::Fitting model to feature number 376, F396
## 2026-05-31 06:37:37.88229 INFO::Fitting model to feature number 377, F397
## 2026-05-31 06:37:37.884472 INFO::Fitting model to feature number 378, F398
## 2026-05-31 06:37:37.886702 INFO::Fitting model to feature number 379, F399
## 2026-05-31 06:37:37.888886 INFO::Fitting model to feature number 380, F400
## 2026-05-31 06:37:37.891101 INFO::Fitting model to feature number 381, F401
## 2026-05-31 06:37:37.893311 INFO::Fitting model to feature number 382, F402
## 2026-05-31 06:37:37.895528 INFO::Fitting model to feature number 383, F403
## 2026-05-31 06:37:37.897745 INFO::Fitting model to feature number 384, F404
## 2026-05-31 06:37:37.899972 INFO::Fitting model to feature number 385, F406
## 2026-05-31 06:37:37.902283 INFO::Fitting model to feature number 386, F407
## 2026-05-31 06:37:37.904496 INFO::Fitting model to feature number 387, F408
## 2026-05-31 06:37:37.906679 INFO::Fitting model to feature number 388, F409
## 2026-05-31 06:37:37.908852 INFO::Fitting model to feature number 389, F410
## 2026-05-31 06:37:37.911035 INFO::Fitting model to feature number 390, F411
## 2026-05-31 06:37:37.913239 INFO::Fitting model to feature number 391, F412
## 2026-05-31 06:37:37.915414 INFO::Fitting model to feature number 392, F413
## 2026-05-31 06:37:37.917586 INFO::Fitting model to feature number 393, F414
## 2026-05-31 06:37:37.919797 INFO::Fitting model to feature number 394, F415
## 2026-05-31 06:37:37.922038 INFO::Fitting model to feature number 395, F417
## 2026-05-31 06:37:37.924264 INFO::Fitting model to feature number 396, F418
## 2026-05-31 06:37:37.926476 INFO::Fitting model to feature number 397, F419
## 2026-05-31 06:37:37.928758 INFO::Fitting model to feature number 398, F420
## 2026-05-31 06:37:37.930965 INFO::Fitting model to feature number 399, F421
## 2026-05-31 06:37:37.933192 INFO::Fitting model to feature number 400, F422
## 2026-05-31 06:37:37.935414 INFO::Fitting model to feature number 401, F423
## 2026-05-31 06:37:37.937642 INFO::Fitting model to feature number 402, F425
## 2026-05-31 06:37:37.939835 INFO::Fitting model to feature number 403, F426
## 2026-05-31 06:37:37.94203 INFO::Fitting model to feature number 404, F428
## 2026-05-31 06:37:37.944238 INFO::Fitting model to feature number 405, F429
## 2026-05-31 06:37:37.946464 INFO::Fitting model to feature number 406, F430
## 2026-05-31 06:37:37.948678 INFO::Fitting model to feature number 407, F431
## 2026-05-31 06:37:37.950939 INFO::Fitting model to feature number 408, F432
## 2026-05-31 06:37:37.953218 INFO::Fitting model to feature number 409, F433
## 2026-05-31 06:37:37.955436 INFO::Fitting model to feature number 410, F434
## 2026-05-31 06:37:37.957666 INFO::Fitting model to feature number 411, F435
## 2026-05-31 06:37:37.959872 INFO::Fitting model to feature number 412, F436
## 2026-05-31 06:37:37.962093 INFO::Fitting model to feature number 413, F437
## 2026-05-31 06:37:37.964283 INFO::Fitting model to feature number 414, F438
## 2026-05-31 06:37:37.966525 INFO::Fitting model to feature number 415, F439
## 2026-05-31 06:37:37.968799 INFO::Fitting model to feature number 416, F440
## 2026-05-31 06:37:37.971036 INFO::Fitting model to feature number 417, F441
## 2026-05-31 06:37:37.973272 INFO::Fitting model to feature number 418, F442
## 2026-05-31 06:37:37.975495 INFO::Fitting model to feature number 419, F443
## 2026-05-31 06:37:37.97771 INFO::Fitting model to feature number 420, F444
## 2026-05-31 06:37:37.979911 INFO::Fitting model to feature number 421, F445
## 2026-05-31 06:37:37.982129 INFO::Fitting model to feature number 422, F446
## 2026-05-31 06:37:37.984355 INFO::Fitting model to feature number 423, F447
## 2026-05-31 06:37:37.986555 INFO::Fitting model to feature number 424, F448
## 2026-05-31 06:37:37.988752 INFO::Fitting model to feature number 425, F449
## 2026-05-31 06:37:37.990966 INFO::Fitting model to feature number 426, F450
## 2026-05-31 06:37:37.993198 INFO::Fitting model to feature number 427, F451
## 2026-05-31 06:37:37.9954 INFO::Fitting model to feature number 428, F452
## 2026-05-31 06:37:37.997591 INFO::Fitting model to feature number 429, F454
## 2026-05-31 06:37:37.999804 INFO::Fitting model to feature number 430, F455
## 2026-05-31 06:37:38.002033 INFO::Fitting model to feature number 431, F456
## 2026-05-31 06:37:38.0043 INFO::Fitting model to feature number 432, F457
## 2026-05-31 06:37:38.006535 INFO::Fitting model to feature number 433, F458
## 2026-05-31 06:37:38.008747 INFO::Fitting model to feature number 434, F459
## 2026-05-31 06:37:38.010968 INFO::Fitting model to feature number 435, F461
## 2026-05-31 06:37:38.013194 INFO::Fitting model to feature number 436, F462
## 2026-05-31 06:37:38.015411 INFO::Fitting model to feature number 437, F463
## 2026-05-31 06:37:38.017635 INFO::Fitting model to feature number 438, F464
## 2026-05-31 06:37:38.019855 INFO::Fitting model to feature number 439, F465
## 2026-05-31 06:37:38.022095 INFO::Fitting model to feature number 440, F466
## 2026-05-31 06:37:38.02431 INFO::Fitting model to feature number 441, F467
## 2026-05-31 06:37:38.026515 INFO::Fitting model to feature number 442, F468
## 2026-05-31 06:37:38.02872 INFO::Fitting model to feature number 443, F469
## 2026-05-31 06:37:38.030939 INFO::Fitting model to feature number 444, F470
## 2026-05-31 06:37:38.033158 INFO::Fitting model to feature number 445, F471
## 2026-05-31 06:37:38.035409 INFO::Fitting model to feature number 446, F474
## 2026-05-31 06:37:38.037625 INFO::Fitting model to feature number 447, F475
## 2026-05-31 06:37:38.03984 INFO::Fitting model to feature number 448, F476
## 2026-05-31 06:37:38.042058 INFO::Fitting model to feature number 449, F477
## 2026-05-31 06:37:38.044282 INFO::Fitting model to feature number 450, F478
## 2026-05-31 06:37:38.046487 INFO::Fitting model to feature number 451, F479
## 2026-05-31 06:37:38.0487 INFO::Fitting model to feature number 452, F480
## 2026-05-31 06:37:38.050918 INFO::Fitting model to feature number 453, F481
## 2026-05-31 06:37:38.053134 INFO::Fitting model to feature number 454, F482
## 2026-05-31 06:37:38.055337 INFO::Fitting model to feature number 455, F483
## 2026-05-31 06:37:38.05755 INFO::Fitting model to feature number 456, F484
## 2026-05-31 06:37:38.059752 INFO::Fitting model to feature number 457, F485
## 2026-05-31 06:37:38.061952 INFO::Fitting model to feature number 458, F486
## 2026-05-31 06:37:38.064193 INFO::Fitting model to feature number 459, F487
## 2026-05-31 06:37:38.066401 INFO::Fitting model to feature number 460, F488
## 2026-05-31 06:37:38.068593 INFO::Fitting model to feature number 461, F489
## 2026-05-31 06:37:38.070789 INFO::Fitting model to feature number 462, F490
## 2026-05-31 06:37:38.073008 INFO::Fitting model to feature number 463, F491
## 2026-05-31 06:37:38.075244 INFO::Fitting model to feature number 464, F492
## 2026-05-31 06:37:38.07746 INFO::Fitting model to feature number 465, F493
## 2026-05-31 06:37:38.079675 INFO::Fitting model to feature number 466, F494
## 2026-05-31 06:37:38.081859 INFO::Fitting model to feature number 467, F495
## 2026-05-31 06:37:38.084079 INFO::Fitting model to feature number 468, F496
## 2026-05-31 06:37:38.086297 INFO::Fitting model to feature number 469, F497
## 2026-05-31 06:37:38.088498 INFO::Fitting model to feature number 470, F498
## 2026-05-31 06:37:38.090716 INFO::Fitting model to feature number 471, F499
## 2026-05-31 06:37:38.092923 INFO::Fitting model to feature number 472, F500
## 2026-05-31 06:37:38.095178 INFO::Fitting model to feature number 473, F501
## 2026-05-31 06:37:38.097373 INFO::Fitting model to feature number 474, F502
## 2026-05-31 06:37:38.099589 INFO::Fitting model to feature number 475, F503
## 2026-05-31 06:37:38.101795 INFO::Fitting model to feature number 476, F504
## 2026-05-31 06:37:38.10403 INFO::Fitting model to feature number 477, F505
## 2026-05-31 06:37:38.106246 INFO::Fitting model to feature number 478, F506
## 2026-05-31 06:37:38.108454 INFO::Fitting model to feature number 479, F507
## 2026-05-31 06:37:38.110705 INFO::Fitting model to feature number 480, F508
## 2026-05-31 06:37:38.112942 INFO::Fitting model to feature number 481, F509
## 2026-05-31 06:37:38.11518 INFO::Fitting model to feature number 482, F510
## 2026-05-31 06:37:38.117396 INFO::Fitting model to feature number 483, F511
## 2026-05-31 06:37:38.119634 INFO::Fitting model to feature number 484, F512
## 2026-05-31 06:37:38.121838 INFO::Fitting model to feature number 485, F513
## 2026-05-31 06:37:38.124048 INFO::Fitting model to feature number 486, F514
## 2026-05-31 06:37:38.126296 INFO::Fitting model to feature number 487, F515
## 2026-05-31 06:37:38.128515 INFO::Fitting model to feature number 488, F516
## 2026-05-31 06:37:38.130728 INFO::Fitting model to feature number 489, F517
## 2026-05-31 06:37:38.132955 INFO::Fitting model to feature number 490, F518
## 2026-05-31 06:37:38.135184 INFO::Fitting model to feature number 491, F519
## 2026-05-31 06:37:38.137385 INFO::Fitting model to feature number 492, F520
## 2026-05-31 06:37:38.139577 INFO::Fitting model to feature number 493, F521
## 2026-05-31 06:37:38.141776 INFO::Fitting model to feature number 494, F522
## 2026-05-31 06:37:38.143997 INFO::Fitting model to feature number 495, F523
## 2026-05-31 06:37:38.146243 INFO::Fitting model to feature number 496, F524
## 2026-05-31 06:37:38.14844 INFO::Fitting model to feature number 497, F525
## 2026-05-31 06:37:38.15064 INFO::Fitting model to feature number 498, F526
## 2026-05-31 06:37:38.152852 INFO::Fitting model to feature number 499, F527
## 2026-05-31 06:37:38.155092 INFO::Fitting model to feature number 500, F528
## 2026-05-31 06:37:38.1573 INFO::Fitting model to feature number 501, F529
## 2026-05-31 06:37:38.159534 INFO::Fitting model to feature number 502, F530
## 2026-05-31 06:37:38.16174 INFO::Fitting model to feature number 503, F531
## 2026-05-31 06:37:38.163953 INFO::Fitting model to feature number 504, F532
## 2026-05-31 06:37:38.16626 INFO::Fitting model to feature number 505, F533
## 2026-05-31 06:37:38.168453 INFO::Fitting model to feature number 506, F534
## 2026-05-31 06:37:38.170633 INFO::Fitting model to feature number 507, F535
## 2026-05-31 06:37:38.172922 INFO::Fitting model to feature number 508, F536
## 2026-05-31 06:37:38.175168 INFO::Fitting model to feature number 509, F537
## 2026-05-31 06:37:38.177422 INFO::Fitting model to feature number 510, F539
## 2026-05-31 06:37:38.17963 INFO::Fitting model to feature number 511, F540
## 2026-05-31 06:37:38.181823 INFO::Fitting model to feature number 512, F541
## 2026-05-31 06:37:38.184041 INFO::Fitting model to feature number 513, F543
## 2026-05-31 06:37:38.186283 INFO::Fitting model to feature number 514, F544
## 2026-05-31 06:37:38.188474 INFO::Fitting model to feature number 515, F545
## 2026-05-31 06:37:38.190666 INFO::Fitting model to feature number 516, F546
## 2026-05-31 06:37:38.192885 INFO::Fitting model to feature number 517, F547
## 2026-05-31 06:37:38.195103 INFO::Fitting model to feature number 518, F548
## 2026-05-31 06:37:38.197296 INFO::Fitting model to feature number 519, F549
## 2026-05-31 06:37:38.199527 INFO::Fitting model to feature number 520, F550
## 2026-05-31 06:37:38.201715 INFO::Fitting model to feature number 521, F551
## 2026-05-31 06:37:38.203949 INFO::Fitting model to feature number 522, F552
## 2026-05-31 06:37:38.206229 INFO::Fitting model to feature number 523, F553
## 2026-05-31 06:37:38.208442 INFO::Fitting model to feature number 524, F554
## 2026-05-31 06:37:38.210648 INFO::Fitting model to feature number 525, F555
## 2026-05-31 06:37:38.212868 INFO::Fitting model to feature number 526, F556
## 2026-05-31 06:37:38.215107 INFO::Fitting model to feature number 527, F557
## 2026-05-31 06:37:38.217334 INFO::Fitting model to feature number 528, F558
## 2026-05-31 06:37:38.219531 INFO::Fitting model to feature number 529, F559
## 2026-05-31 06:37:38.221731 INFO::Fitting model to feature number 530, F560
## 2026-05-31 06:37:38.224094 INFO::Fitting model to feature number 531, F561
## 2026-05-31 06:37:38.226307 INFO::Fitting model to feature number 532, F562
## 2026-05-31 06:37:38.228516 INFO::Fitting model to feature number 533, F563
## 2026-05-31 06:37:38.230716 INFO::Fitting model to feature number 534, F564
## 2026-05-31 06:37:38.232945 INFO::Fitting model to feature number 535, F566
## 2026-05-31 06:37:38.235174 INFO::Fitting model to feature number 536, F567
## 2026-05-31 06:37:38.237374 INFO::Fitting model to feature number 537, F568
## 2026-05-31 06:37:38.239624 INFO::Fitting model to feature number 538, F569
## 2026-05-31 06:37:38.241845 INFO::Fitting model to feature number 539, F570
## 2026-05-31 06:37:38.244084 INFO::Fitting model to feature number 540, F571
## 2026-05-31 06:37:38.246292 INFO::Fitting model to feature number 541, F572
## 2026-05-31 06:37:38.248492 INFO::Fitting model to feature number 542, F573
## 2026-05-31 06:37:38.250688 INFO::Fitting model to feature number 543, F574
## 2026-05-31 06:37:38.252919 INFO::Fitting model to feature number 544, F575
## 2026-05-31 06:37:38.255132 INFO::Fitting model to feature number 545, F576
## 2026-05-31 06:37:38.2574 INFO::Fitting model to feature number 546, F578
## 2026-05-31 06:37:38.273323 INFO::Fitting model to feature number 547, F579
## 2026-05-31 06:37:38.275684 INFO::Fitting model to feature number 548, F580
## 2026-05-31 06:37:38.277899 INFO::Fitting model to feature number 549, F581
## 2026-05-31 06:37:38.280115 INFO::Fitting model to feature number 550, F582
## 2026-05-31 06:37:38.282322 INFO::Fitting model to feature number 551, F583
## 2026-05-31 06:37:38.284515 INFO::Fitting model to feature number 552, F584
## 2026-05-31 06:37:38.286825 INFO::Fitting model to feature number 553, F585
## 2026-05-31 06:37:38.289219 INFO::Fitting model to feature number 554, F586
## 2026-05-31 06:37:38.291442 INFO::Fitting model to feature number 555, F587
## 2026-05-31 06:37:38.293641 INFO::Fitting model to feature number 556, F588
## 2026-05-31 06:37:38.295851 INFO::Fitting model to feature number 557, F589
## 2026-05-31 06:37:38.298111 INFO::Fitting model to feature number 558, F590
## 2026-05-31 06:37:38.300348 INFO::Fitting model to feature number 559, F591
## 2026-05-31 06:37:38.302579 INFO::Fitting model to feature number 560, F592
## 2026-05-31 06:37:38.304777 INFO::Fitting model to feature number 561, F593
## 2026-05-31 06:37:38.30699 INFO::Fitting model to feature number 562, F594
## 2026-05-31 06:37:38.309193 INFO::Fitting model to feature number 563, F595
## 2026-05-31 06:37:38.311383 INFO::Fitting model to feature number 564, F596
## 2026-05-31 06:37:38.313577 INFO::Fitting model to feature number 565, F597
## 2026-05-31 06:37:38.315794 INFO::Fitting model to feature number 566, F598
## 2026-05-31 06:37:38.317981 INFO::Fitting model to feature number 567, F599
## 2026-05-31 06:37:38.320238 INFO::Fitting model to feature number 568, F600
## 2026-05-31 06:37:38.322469 INFO::Fitting model to feature number 569, F601
## 2026-05-31 06:37:38.324699 INFO::Fitting model to feature number 570, F602
## 2026-05-31 06:37:38.326943 INFO::Fitting model to feature number 571, F603
## 2026-05-31 06:37:38.329217 INFO::Fitting model to feature number 572, F605
## 2026-05-31 06:37:38.331455 INFO::Fitting model to feature number 573, F606
## 2026-05-31 06:37:38.333808 INFO::Fitting model to feature number 574, F607
## 2026-05-31 06:37:38.336088 INFO::Fitting model to feature number 575, F608
## 2026-05-31 06:37:38.338314 INFO::Fitting model to feature number 576, F609
## 2026-05-31 06:37:38.340554 INFO::Fitting model to feature number 577, F610
## 2026-05-31 06:37:38.342796 INFO::Fitting model to feature number 578, F611
## 2026-05-31 06:37:38.345137 INFO::Fitting model to feature number 579, F612
## 2026-05-31 06:37:38.347524 INFO::Fitting model to feature number 580, F613
## 2026-05-31 06:37:38.349856 INFO::Fitting model to feature number 581, F614
## 2026-05-31 06:37:38.352153 INFO::Fitting model to feature number 582, F615
## 2026-05-31 06:37:38.354386 INFO::Fitting model to feature number 583, F616
## 2026-05-31 06:37:38.356595 INFO::Fitting model to feature number 584, F617
## 2026-05-31 06:37:38.358798 INFO::Fitting model to feature number 585, F618
## 2026-05-31 06:37:38.361 INFO::Fitting model to feature number 586, F619
## 2026-05-31 06:37:38.363234 INFO::Fitting model to feature number 587, F620
## 2026-05-31 06:37:38.365439 INFO::Fitting model to feature number 588, F621
## 2026-05-31 06:37:38.367664 INFO::Fitting model to feature number 589, F622
## 2026-05-31 06:37:38.36985 INFO::Fitting model to feature number 590, F623
## 2026-05-31 06:37:38.372043 INFO::Fitting model to feature number 591, F624
## 2026-05-31 06:37:38.374275 INFO::Fitting model to feature number 592, F625
## 2026-05-31 06:37:38.376477 INFO::Fitting model to feature number 593, F626
## 2026-05-31 06:37:38.378671 INFO::Fitting model to feature number 594, F627
## 2026-05-31 06:37:38.380854 INFO::Fitting model to feature number 595, F628
## 2026-05-31 06:37:38.38304 INFO::Fitting model to feature number 596, F630
## 2026-05-31 06:37:38.385268 INFO::Fitting model to feature number 597, F631
## 2026-05-31 06:37:38.387459 INFO::Fitting model to feature number 598, F632
## 2026-05-31 06:37:38.38964 INFO::Fitting model to feature number 599, F633
## 2026-05-31 06:37:38.391838 INFO::Fitting model to feature number 600, F634
## 2026-05-31 06:37:38.394034 INFO::Fitting model to feature number 601, F635
## 2026-05-31 06:37:38.396263 INFO::Fitting model to feature number 602, F636
## 2026-05-31 06:37:38.398459 INFO::Fitting model to feature number 603, F637
## 2026-05-31 06:37:38.400699 INFO::Fitting model to feature number 604, F638
## 2026-05-31 06:37:38.402921 INFO::Fitting model to feature number 605, F639
## 2026-05-31 06:37:38.405185 INFO::Fitting model to feature number 606, F640
## 2026-05-31 06:37:38.40739 INFO::Fitting model to feature number 607, F641
## 2026-05-31 06:37:38.409629 INFO::Fitting model to feature number 608, F642
## 2026-05-31 06:37:38.411899 INFO::Fitting model to feature number 609, F643
## 2026-05-31 06:37:38.414193 INFO::Fitting model to feature number 610, F644
## 2026-05-31 06:37:38.416403 INFO::Fitting model to feature number 611, F645
## 2026-05-31 06:37:38.418611 INFO::Fitting model to feature number 612, F646
## 2026-05-31 06:37:38.420831 INFO::Fitting model to feature number 613, F647
## 2026-05-31 06:37:38.423088 INFO::Fitting model to feature number 614, F648
## 2026-05-31 06:37:38.425309 INFO::Fitting model to feature number 615, F649
## 2026-05-31 06:37:38.427531 INFO::Fitting model to feature number 616, F650
## 2026-05-31 06:37:38.429801 INFO::Fitting model to feature number 617, F651
## 2026-05-31 06:37:38.432002 INFO::Fitting model to feature number 618, F652
## 2026-05-31 06:37:38.434244 INFO::Fitting model to feature number 619, F653
## 2026-05-31 06:37:38.43646 INFO::Fitting model to feature number 620, F654
## 2026-05-31 06:37:38.438658 INFO::Fitting model to feature number 621, F655
## 2026-05-31 06:37:38.440912 INFO::Fitting model to feature number 622, F656
## 2026-05-31 06:37:38.443158 INFO::Fitting model to feature number 623, F657
## 2026-05-31 06:37:38.445347 INFO::Fitting model to feature number 624, F658
## 2026-05-31 06:37:38.44752 INFO::Fitting model to feature number 625, F659
## 2026-05-31 06:37:38.449697 INFO::Fitting model to feature number 626, F660
## 2026-05-31 06:37:38.4519 INFO::Fitting model to feature number 627, F661
## 2026-05-31 06:37:38.454125 INFO::Fitting model to feature number 628, F662
## 2026-05-31 06:37:38.456341 INFO::Fitting model to feature number 629, F663
## 2026-05-31 06:37:38.458555 INFO::Fitting model to feature number 630, F664
## 2026-05-31 06:37:38.460753 INFO::Fitting model to feature number 631, F665
## 2026-05-31 06:37:38.462966 INFO::Fitting model to feature number 632, F666
## 2026-05-31 06:37:38.46521 INFO::Fitting model to feature number 633, F667
## 2026-05-31 06:37:38.467414 INFO::Fitting model to feature number 634, F668
## 2026-05-31 06:37:38.469596 INFO::Fitting model to feature number 635, F669
## 2026-05-31 06:37:38.471762 INFO::Fitting model to feature number 636, F670
## 2026-05-31 06:37:38.47393 INFO::Fitting model to feature number 637, F671
## 2026-05-31 06:37:38.476141 INFO::Fitting model to feature number 638, F673
## 2026-05-31 06:37:38.478357 INFO::Fitting model to feature number 639, F674
## 2026-05-31 06:37:38.480573 INFO::Fitting model to feature number 640, F675
## 2026-05-31 06:37:38.482774 INFO::Fitting model to feature number 641, F676
## 2026-05-31 06:37:38.484942 INFO::Fitting model to feature number 642, F677
## 2026-05-31 06:37:38.487196 INFO::Fitting model to feature number 643, F678
## 2026-05-31 06:37:38.489442 INFO::Fitting model to feature number 644, F679
## 2026-05-31 06:37:38.491698 INFO::Fitting model to feature number 645, F680
## 2026-05-31 06:37:38.493928 INFO::Fitting model to feature number 646, F681
## 2026-05-31 06:37:38.496167 INFO::Fitting model to feature number 647, F682
## 2026-05-31 06:37:38.498478 INFO::Fitting model to feature number 648, F683
## 2026-05-31 06:37:38.500656 INFO::Fitting model to feature number 649, F684
## 2026-05-31 06:37:38.502852 INFO::Fitting model to feature number 650, F685
## 2026-05-31 06:37:38.505084 INFO::Fitting model to feature number 651, F686
## 2026-05-31 06:37:38.507373 INFO::Fitting model to feature number 652, F687
## 2026-05-31 06:37:38.509563 INFO::Fitting model to feature number 653, F688
## 2026-05-31 06:37:38.51177 INFO::Fitting model to feature number 654, F689
## 2026-05-31 06:37:38.513999 INFO::Fitting model to feature number 655, F690
## 2026-05-31 06:37:38.51623 INFO::Fitting model to feature number 656, F691
## 2026-05-31 06:37:38.518456 INFO::Fitting model to feature number 657, F692
## 2026-05-31 06:37:38.520662 INFO::Fitting model to feature number 658, F693
## 2026-05-31 06:37:38.522909 INFO::Fitting model to feature number 659, F694
## 2026-05-31 06:37:38.525127 INFO::Fitting model to feature number 660, F695
## 2026-05-31 06:37:38.52734 INFO::Fitting model to feature number 661, F696
## 2026-05-31 06:37:38.529535 INFO::Fitting model to feature number 662, F697
## 2026-05-31 06:37:38.531747 INFO::Fitting model to feature number 663, F698
## 2026-05-31 06:37:38.533975 INFO::Fitting model to feature number 664, F699
## 2026-05-31 06:37:38.536212 INFO::Fitting model to feature number 665, F700
## 2026-05-31 06:37:38.538407 INFO::Fitting model to feature number 666, F701
## 2026-05-31 06:37:38.54063 INFO::Fitting model to feature number 667, F702
## 2026-05-31 06:37:38.542852 INFO::Fitting model to feature number 668, F704
## 2026-05-31 06:37:38.545035 INFO::Fitting model to feature number 669, F705
## 2026-05-31 06:37:38.547268 INFO::Fitting model to feature number 670, F706
## 2026-05-31 06:37:38.549495 INFO::Fitting model to feature number 671, F707
## 2026-05-31 06:37:38.5517 INFO::Fitting model to feature number 672, F708
## 2026-05-31 06:37:38.553917 INFO::Fitting model to feature number 673, F709
## 2026-05-31 06:37:38.556119 INFO::Fitting model to feature number 674, F710
## 2026-05-31 06:37:38.558336 INFO::Fitting model to feature number 675, F711
## 2026-05-31 06:37:38.560542 INFO::Fitting model to feature number 676, F712
## 2026-05-31 06:37:38.56276 INFO::Fitting model to feature number 677, F713
## 2026-05-31 06:37:38.564992 INFO::Fitting model to feature number 678, F714
## 2026-05-31 06:37:38.56721 INFO::Fitting model to feature number 679, F715
## 2026-05-31 06:37:38.569407 INFO::Fitting model to feature number 680, F716
## 2026-05-31 06:37:38.571632 INFO::Fitting model to feature number 681, F717
## 2026-05-31 06:37:38.573847 INFO::Fitting model to feature number 682, F718
## 2026-05-31 06:37:38.57608 INFO::Fitting model to feature number 683, F719
## 2026-05-31 06:37:38.578292 INFO::Fitting model to feature number 684, F720
## 2026-05-31 06:37:38.580493 INFO::Fitting model to feature number 685, F721
## 2026-05-31 06:37:38.582752 INFO::Fitting model to feature number 686, F722
## 2026-05-31 06:37:38.58497 INFO::Fitting model to feature number 687, F723
## 2026-05-31 06:37:38.587195 INFO::Fitting model to feature number 688, F724
## 2026-05-31 06:37:38.589422 INFO::Fitting model to feature number 689, F725
## 2026-05-31 06:37:38.59163 INFO::Fitting model to feature number 690, F726
## 2026-05-31 06:37:38.593833 INFO::Fitting model to feature number 691, F727
## 2026-05-31 06:37:38.596043 INFO::Fitting model to feature number 692, F728
## 2026-05-31 06:37:38.598254 INFO::Fitting model to feature number 693, F729
## 2026-05-31 06:37:38.600451 INFO::Fitting model to feature number 694, F730
## 2026-05-31 06:37:38.602651 INFO::Fitting model to feature number 695, F731
## 2026-05-31 06:37:38.604869 INFO::Fitting model to feature number 696, F732
## 2026-05-31 06:37:38.607202 INFO::Fitting model to feature number 697, F733
## 2026-05-31 06:37:38.609415 INFO::Fitting model to feature number 698, F734
## 2026-05-31 06:37:38.611634 INFO::Fitting model to feature number 699, F735
## 2026-05-31 06:37:38.61384 INFO::Fitting model to feature number 700, F736
## 2026-05-31 06:37:38.616037 INFO::Fitting model to feature number 701, F737
## 2026-05-31 06:37:38.618275 INFO::Fitting model to feature number 702, F739
## 2026-05-31 06:37:38.620465 INFO::Fitting model to feature number 703, F740
## 2026-05-31 06:37:38.622663 INFO::Fitting model to feature number 704, F741
## 2026-05-31 06:37:38.6249 INFO::Fitting model to feature number 705, F742
## 2026-05-31 06:37:38.627133 INFO::Fitting model to feature number 706, F743
## 2026-05-31 06:37:38.629328 INFO::Fitting model to feature number 707, F745
## 2026-05-31 06:37:38.631527 INFO::Fitting model to feature number 708, F746
## 2026-05-31 06:37:38.633753 INFO::Fitting model to feature number 709, F747
## 2026-05-31 06:37:38.635961 INFO::Fitting model to feature number 710, F748
## 2026-05-31 06:37:38.638195 INFO::Fitting model to feature number 711, F749
## 2026-05-31 06:37:38.640403 INFO::Fitting model to feature number 712, F750
## 2026-05-31 06:37:38.642631 INFO::Fitting model to feature number 713, F751
## 2026-05-31 06:37:38.644825 INFO::Fitting model to feature number 714, F752
## 2026-05-31 06:37:38.647036 INFO::Fitting model to feature number 715, F753
## 2026-05-31 06:37:38.649294 INFO::Fitting model to feature number 716, F755
## 2026-05-31 06:37:38.651492 INFO::Fitting model to feature number 717, F756
## 2026-05-31 06:37:38.653705 INFO::Fitting model to feature number 718, F757
## 2026-05-31 06:37:38.655912 INFO::Fitting model to feature number 719, F758
## 2026-05-31 06:37:38.658138 INFO::Fitting model to feature number 720, F759
## 2026-05-31 06:37:38.660341 INFO::Fitting model to feature number 721, F760
## 2026-05-31 06:37:38.66255 INFO::Fitting model to feature number 722, F761
## 2026-05-31 06:37:38.66476 INFO::Fitting model to feature number 723, F762
## 2026-05-31 06:37:38.666953 INFO::Fitting model to feature number 724, F763
## 2026-05-31 06:37:38.669166 INFO::Fitting model to feature number 725, F764
## 2026-05-31 06:37:38.671356 INFO::Fitting model to feature number 726, F765
## 2026-05-31 06:37:38.673571 INFO::Fitting model to feature number 727, F766
## 2026-05-31 06:37:38.675781 INFO::Fitting model to feature number 728, F767
## 2026-05-31 06:37:38.677985 INFO::Fitting model to feature number 729, F768
## 2026-05-31 06:37:38.680206 INFO::Fitting model to feature number 730, F769
## 2026-05-31 06:37:38.682422 INFO::Fitting model to feature number 731, F770
## 2026-05-31 06:37:38.684618 INFO::Fitting model to feature number 732, F771
## 2026-05-31 06:37:38.686875 INFO::Fitting model to feature number 733, F772
## 2026-05-31 06:37:38.689118 INFO::Fitting model to feature number 734, F773
## 2026-05-31 06:37:38.691327 INFO::Fitting model to feature number 735, F774
## 2026-05-31 06:37:38.693557 INFO::Fitting model to feature number 736, F775
## 2026-05-31 06:37:38.69575 INFO::Fitting model to feature number 737, F776
## 2026-05-31 06:37:38.69796 INFO::Fitting model to feature number 738, F777
## 2026-05-31 06:37:38.700196 INFO::Fitting model to feature number 739, F778
## 2026-05-31 06:37:38.702423 INFO::Fitting model to feature number 740, F779
## 2026-05-31 06:37:38.705079 INFO::Fitting model to feature number 741, F780
## 2026-05-31 06:37:38.707377 INFO::Fitting model to feature number 742, F781
## 2026-05-31 06:37:38.709601 INFO::Fitting model to feature number 743, F782
## 2026-05-31 06:37:38.711805 INFO::Fitting model to feature number 744, F783
## 2026-05-31 06:37:38.714052 INFO::Fitting model to feature number 745, F784
## 2026-05-31 06:37:38.716282 INFO::Fitting model to feature number 746, F785
## 2026-05-31 06:37:38.718502 INFO::Fitting model to feature number 747, F786
## 2026-05-31 06:37:38.720718 INFO::Fitting model to feature number 748, F787
## 2026-05-31 06:37:38.722943 INFO::Fitting model to feature number 749, F788
## 2026-05-31 06:37:38.725163 INFO::Fitting model to feature number 750, F789
## 2026-05-31 06:37:38.727374 INFO::Fitting model to feature number 751, F790
## 2026-05-31 06:37:38.729565 INFO::Fitting model to feature number 752, F791
## 2026-05-31 06:37:38.731778 INFO::Fitting model to feature number 753, F792
## 2026-05-31 06:37:38.733979 INFO::Fitting model to feature number 754, F793
## 2026-05-31 06:37:38.736222 INFO::Fitting model to feature number 755, F794
## 2026-05-31 06:37:38.738423 INFO::Fitting model to feature number 756, F795
## 2026-05-31 06:37:38.740605 INFO::Fitting model to feature number 757, F796
## 2026-05-31 06:37:38.742865 INFO::Fitting model to feature number 758, F797
## 2026-05-31 06:37:38.745111 INFO::Fitting model to feature number 759, F798
## 2026-05-31 06:37:38.74733 INFO::Fitting model to feature number 760, F799
## 2026-05-31 06:37:38.749559 INFO::Fitting model to feature number 761, F800
## 2026-05-31 06:37:38.751754 INFO::Fitting model to feature number 762, F801
## 2026-05-31 06:37:38.753962 INFO::Fitting model to feature number 763, F802
## 2026-05-31 06:37:38.756171 INFO::Fitting model to feature number 764, F803
## 2026-05-31 06:37:38.758381 INFO::Fitting model to feature number 765, F804
## 2026-05-31 06:37:38.760568 INFO::Fitting model to feature number 766, F805
## 2026-05-31 06:37:38.762798 INFO::Fitting model to feature number 767, F806
## 2026-05-31 06:37:38.765001 INFO::Fitting model to feature number 768, F808
## 2026-05-31 06:37:38.767229 INFO::Fitting model to feature number 769, F809
## 2026-05-31 06:37:38.769445 INFO::Fitting model to feature number 770, F810
## 2026-05-31 06:37:38.77175 INFO::Fitting model to feature number 771, F811
## 2026-05-31 06:37:38.773973 INFO::Fitting model to feature number 772, F812
## 2026-05-31 06:37:38.776224 INFO::Fitting model to feature number 773, F813
## 2026-05-31 06:37:38.778417 INFO::Fitting model to feature number 774, F814
## 2026-05-31 06:37:38.780614 INFO::Fitting model to feature number 775, F815
## 2026-05-31 06:37:38.782832 INFO::Fitting model to feature number 776, F816
## 2026-05-31 06:37:38.785041 INFO::Fitting model to feature number 777, F817
## 2026-05-31 06:37:38.787481 INFO::Fitting model to feature number 778, F818
## 2026-05-31 06:37:38.80334 INFO::Fitting model to feature number 779, F819
## 2026-05-31 06:37:38.805673 INFO::Fitting model to feature number 780, F820
## 2026-05-31 06:37:38.807881 INFO::Fitting model to feature number 781, F821
## 2026-05-31 06:37:38.810101 INFO::Fitting model to feature number 782, F822
## 2026-05-31 06:37:38.812292 INFO::Fitting model to feature number 783, F823
## 2026-05-31 06:37:38.814484 INFO::Fitting model to feature number 784, F824
## 2026-05-31 06:37:38.816693 INFO::Fitting model to feature number 785, F825
## 2026-05-31 06:37:38.818885 INFO::Fitting model to feature number 786, F826
## 2026-05-31 06:37:38.821104 INFO::Fitting model to feature number 787, F827
## 2026-05-31 06:37:38.823323 INFO::Fitting model to feature number 788, F828
## 2026-05-31 06:37:38.825553 INFO::Fitting model to feature number 789, F829
## 2026-05-31 06:37:38.827785 INFO::Fitting model to feature number 790, F830
## 2026-05-31 06:37:38.830029 INFO::Fitting model to feature number 791, F831
## 2026-05-31 06:37:38.832287 INFO::Fitting model to feature number 792, F832
## 2026-05-31 06:37:38.834522 INFO::Fitting model to feature number 793, F833
## 2026-05-31 06:37:38.836737 INFO::Fitting model to feature number 794, F834
## 2026-05-31 06:37:38.838938 INFO::Fitting model to feature number 795, F835
## 2026-05-31 06:37:38.841145 INFO::Fitting model to feature number 796, F836
## 2026-05-31 06:37:38.843346 INFO::Fitting model to feature number 797, F837
## 2026-05-31 06:37:38.845533 INFO::Fitting model to feature number 798, F838
## 2026-05-31 06:37:38.847732 INFO::Fitting model to feature number 799, F839
## 2026-05-31 06:37:38.84996 INFO::Fitting model to feature number 800, F840
## 2026-05-31 06:37:38.852171 INFO::Fitting model to feature number 801, F841
## 2026-05-31 06:37:38.854384 INFO::Fitting model to feature number 802, F842
## 2026-05-31 06:37:38.856603 INFO::Fitting model to feature number 803, F843
## 2026-05-31 06:37:38.858842 INFO::Fitting model to feature number 804, F844
## 2026-05-31 06:37:38.861125 INFO::Fitting model to feature number 805, F845
## 2026-05-31 06:37:38.863477 INFO::Fitting model to feature number 806, F847
## 2026-05-31 06:37:38.865739 INFO::Fitting model to feature number 807, F848
## 2026-05-31 06:37:38.867969 INFO::Fitting model to feature number 808, F849
## 2026-05-31 06:37:38.870248 INFO::Fitting model to feature number 809, F850
## 2026-05-31 06:37:38.872487 INFO::Fitting model to feature number 810, F851
## 2026-05-31 06:37:38.875129 INFO::Fitting model to feature number 811, F852
## 2026-05-31 06:37:38.878094 INFO::Fitting model to feature number 812, F853
## 2026-05-31 06:37:38.880446 INFO::Fitting model to feature number 813, F854
## 2026-05-31 06:37:38.882739 INFO::Fitting model to feature number 814, F855
## 2026-05-31 06:37:38.884954 INFO::Fitting model to feature number 815, F856
## 2026-05-31 06:37:38.88717 INFO::Fitting model to feature number 816, F857
## 2026-05-31 06:37:38.889373 INFO::Fitting model to feature number 817, F858
## 2026-05-31 06:37:38.891553 INFO::Fitting model to feature number 818, F859
## 2026-05-31 06:37:38.893755 INFO::Fitting model to feature number 819, F860
## 2026-05-31 06:37:38.895976 INFO::Fitting model to feature number 820, F861
## 2026-05-31 06:37:38.898197 INFO::Fitting model to feature number 821, F862
## 2026-05-31 06:37:38.900403 INFO::Fitting model to feature number 822, F863
## 2026-05-31 06:37:38.902617 INFO::Fitting model to feature number 823, F864
## 2026-05-31 06:37:38.90483 INFO::Fitting model to feature number 824, F865
## 2026-05-31 06:37:38.907055 INFO::Fitting model to feature number 825, F866
## 2026-05-31 06:37:38.909263 INFO::Fitting model to feature number 826, F867
## 2026-05-31 06:37:38.911443 INFO::Fitting model to feature number 827, F868
## 2026-05-31 06:37:38.913643 INFO::Fitting model to feature number 828, F869
## 2026-05-31 06:37:38.915857 INFO::Fitting model to feature number 829, F870
## 2026-05-31 06:37:38.918053 INFO::Fitting model to feature number 830, F871
## 2026-05-31 06:37:38.920253 INFO::Fitting model to feature number 831, F872
## 2026-05-31 06:37:38.922436 INFO::Fitting model to feature number 832, F873
## 2026-05-31 06:37:38.924638 INFO::Fitting model to feature number 833, F874
## 2026-05-31 06:37:38.926882 INFO::Fitting model to feature number 834, F875
## 2026-05-31 06:37:38.929185 INFO::Fitting model to feature number 835, F876
## 2026-05-31 06:37:38.931478 INFO::Fitting model to feature number 836, F877
## 2026-05-31 06:37:38.933702 INFO::Fitting model to feature number 837, F878
## 2026-05-31 06:37:38.935935 INFO::Fitting model to feature number 838, F879
## 2026-05-31 06:37:38.938158 INFO::Fitting model to feature number 839, F880
## 2026-05-31 06:37:38.940436 INFO::Fitting model to feature number 840, F881
## 2026-05-31 06:37:38.942762 INFO::Fitting model to feature number 841, F882
## 2026-05-31 06:37:38.945027 INFO::Fitting model to feature number 842, F883
## 2026-05-31 06:37:38.94726 INFO::Fitting model to feature number 843, F884
## 2026-05-31 06:37:38.949481 INFO::Fitting model to feature number 844, F885
## 2026-05-31 06:37:38.951727 INFO::Fitting model to feature number 845, F886
## 2026-05-31 06:37:38.953976 INFO::Fitting model to feature number 846, F887
## 2026-05-31 06:37:38.95623 INFO::Fitting model to feature number 847, F888
## 2026-05-31 06:37:38.958451 INFO::Fitting model to feature number 848, F889
## 2026-05-31 06:37:38.960699 INFO::Fitting model to feature number 849, F890
## 2026-05-31 06:37:38.962947 INFO::Fitting model to feature number 850, F891
## 2026-05-31 06:37:38.965196 INFO::Fitting model to feature number 851, F892
## 2026-05-31 06:37:38.967389 INFO::Fitting model to feature number 852, F893
## 2026-05-31 06:37:38.969608 INFO::Fitting model to feature number 853, F894
## 2026-05-31 06:37:38.971853 INFO::Fitting model to feature number 854, F895
## 2026-05-31 06:37:38.974058 INFO::Fitting model to feature number 855, F896
## 2026-05-31 06:37:38.976251 INFO::Fitting model to feature number 856, F897
## 2026-05-31 06:37:38.978442 INFO::Fitting model to feature number 857, F898
## 2026-05-31 06:37:38.980631 INFO::Fitting model to feature number 858, F899
## 2026-05-31 06:37:38.982811 INFO::Fitting model to feature number 859, F900
## 2026-05-31 06:37:39.093407 INFO::Counting total values for each feature
## 2026-05-31 06:37:39.169665 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2026-05-31 06:37:39.224844 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2026-05-31 06:37:39.278617 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2026-05-31 06:37:39.332291 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2026-05-31 06:37:39.364326 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2026-05-31 06:37:39.390817 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2026-05-31 06:37:39.400107 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2026-05-31 06:37:39.404354 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2026-05-31 06:37:39.41578 INFO::Plotting associations from most to least significant, grouped by metadata
## 2026-05-31 06:37:39.416449 INFO::Plotting data for metadata number 1, diagnosis
## 2026-05-31 06:37:39.443468 INFO::Creating boxplot for categorical data, diagnosis vs F504

## 2026-05-31 06:37:39.725424 INFO::Creating boxplot for categorical data, diagnosis vs F859

## 2026-05-31 06:37:39.916383 INFO::Creating boxplot for categorical data, diagnosis vs F533

## 2026-05-31 06:37:40.109944 INFO::Creating boxplot for categorical data, diagnosis vs F587

## 2026-05-31 06:37:40.290537 INFO::Creating boxplot for categorical data, diagnosis vs F584

## 2026-05-31 06:37:40.470744 INFO::Creating boxplot for categorical data, diagnosis vs F197

## 2026-05-31 06:37:40.659578 INFO::Creating boxplot for categorical data, diagnosis vs F380

## 2026-05-31 06:37:40.839759 INFO::Creating boxplot for categorical data, diagnosis vs F829

## 2026-05-31 06:37:41.020951 INFO::Creating boxplot for categorical data, diagnosis vs F664

## 2026-05-31 06:37:41.296306 INFO::Creating boxplot for categorical data, diagnosis vs F93

## 2026-05-31 06:37:41.479547 INFO::Creating boxplot for categorical data, diagnosis vs F15

## 2026-05-31 06:37:41.686317 INFO::Creating boxplot for categorical data, diagnosis vs F881

## 2026-05-31 06:37:41.869771 INFO::Creating boxplot for categorical data, diagnosis vs F806

## 2026-05-31 06:37:42.050692 INFO::Creating boxplot for categorical data, diagnosis vs F78

## 2026-05-31 06:37:42.240563 INFO::Creating boxplot for categorical data, diagnosis vs F189

## 2026-05-31 06:37:42.421453 INFO::Creating boxplot for categorical data, diagnosis vs F369

## 2026-05-31 06:37:42.601408 INFO::Creating boxplot for categorical data, diagnosis vs F623

## 2026-05-31 06:37:42.790587 INFO::Creating boxplot for categorical data, diagnosis vs F710

## 2026-05-31 06:37:42.971605 INFO::Creating boxplot for categorical data, diagnosis vs F851

## 2026-05-31 06:37:43.17244 INFO::Creating boxplot for categorical data, diagnosis vs F257

## 2026-05-31 06:37:43.355016 INFO::Creating boxplot for categorical data, diagnosis vs F330

## 2026-05-31 06:37:43.536526 INFO::Creating boxplot for categorical data, diagnosis vs F344

## 2026-05-31 06:37:43.728173 INFO::Creating boxplot for categorical data, diagnosis vs F696

## 2026-05-31 06:37:43.909783 INFO::Creating boxplot for categorical data, diagnosis vs F741

## 2026-05-31 06:37:44.102094 INFO::Creating boxplot for categorical data, diagnosis vs F509

## 2026-05-31 06:37:44.284535 INFO::Creating boxplot for categorical data, diagnosis vs F479

## 2026-05-31 06:37:44.466891 INFO::Creating boxplot for categorical data, diagnosis vs F550

## 2026-05-31 06:37:44.658968 INFO::Creating boxplot for categorical data, diagnosis vs F640

## 2026-05-31 06:37:44.841422 INFO::Creating boxplot for categorical data, diagnosis vs F281

## 2026-05-31 06:37:45.022407 INFO::Creating boxplot for categorical data, diagnosis vs F80

## 2026-05-31 06:37:45.213906 INFO::Creating boxplot for categorical data, diagnosis vs F285

## 2026-05-31 06:37:45.397231 INFO::Creating boxplot for categorical data, diagnosis vs F531

## 2026-05-31 06:37:45.58984 INFO::Creating boxplot for categorical data, diagnosis vs F737

## 2026-05-31 06:37:45.771172 INFO::Creating boxplot for categorical data, diagnosis vs F875

## 2026-05-31 06:37:45.953496 INFO::Creating boxplot for categorical data, diagnosis vs F864

## 2026-05-31 06:37:46.145249 INFO::Creating boxplot for categorical data, diagnosis vs F379

## 2026-05-31 06:37:46.32744 INFO::Creating boxplot for categorical data, diagnosis vs F190

## 2026-05-31 06:37:46.519398 INFO::Creating boxplot for categorical data, diagnosis vs F4

## 2026-05-31 06:37:46.703228 INFO::Creating boxplot for categorical data, diagnosis vs F591

## 2026-05-31 06:37:46.886246 INFO::Creating boxplot for categorical data, diagnosis vs F773

## 2026-05-31 06:37:47.077877 INFO::Creating boxplot for categorical data, diagnosis vs F283

## 2026-05-31 06:37:47.260137 INFO::Creating boxplot for categorical data, diagnosis vs F233

## 2026-05-31 06:37:47.453729 INFO::Creating boxplot for categorical data, diagnosis vs F420

## 2026-05-31 06:37:47.635674 INFO::Creating boxplot for categorical data, diagnosis vs F5

## 2026-05-31 06:37:47.819789 INFO::Creating boxplot for categorical data, diagnosis vs F137

## 2026-05-31 06:37:48.012181 INFO::Creating boxplot for categorical data, diagnosis vs F215

## 2026-05-31 06:37:48.194561 INFO::Creating boxplot for categorical data, diagnosis vs F489

## 2026-05-31 06:37:48.387703 INFO::Creating boxplot for categorical data, diagnosis vs F220

## 2026-05-31 06:37:48.571087 INFO::Creating boxplot for categorical data, diagnosis vs F691

## 2026-05-31 06:37:48.754621 INFO::Creating boxplot for categorical data, diagnosis vs F381

## 2026-05-31 06:37:48.948029 INFO::Creating boxplot for categorical data, diagnosis vs F539

## 2026-05-31 06:37:49.129273 INFO::Creating boxplot for categorical data, diagnosis vs F490

## 2026-05-31 06:37:49.322593 INFO::Creating boxplot for categorical data, diagnosis vs F832

## 2026-05-31 06:37:49.505221 INFO::Creating boxplot for categorical data, diagnosis vs F396

## 2026-05-31 06:37:49.688174 INFO::Creating boxplot for categorical data, diagnosis vs F528

## 2026-05-31 06:37:49.880519 INFO::Creating boxplot for categorical data, diagnosis vs F178

## 2026-05-31 06:37:50.063744 INFO::Creating boxplot for categorical data, diagnosis vs F761

## 2026-05-31 06:37:50.256897 INFO::Creating boxplot for categorical data, diagnosis vs F2

## 2026-05-31 06:37:50.438855 INFO::Creating boxplot for categorical data, diagnosis vs F260

## 2026-05-31 06:37:50.621857 INFO::Creating boxplot for categorical data, diagnosis vs F234

## 2026-05-31 06:37:50.81411 INFO::Creating boxplot for categorical data, diagnosis vs F734

## 2026-05-31 06:37:50.998758 INFO::Creating boxplot for categorical data, diagnosis vs F429

## 2026-05-31 06:37:51.193648 INFO::Creating boxplot for categorical data, diagnosis vs F630

## 2026-05-31 06:37:51.377429 INFO::Creating boxplot for categorical data, diagnosis vs F817

## 2026-05-31 06:37:51.570165 INFO::Creating boxplot for categorical data, diagnosis vs F847

## 2026-05-31 06:37:51.7545 INFO::Creating boxplot for categorical data, diagnosis vs F896

## 2026-05-31 06:37:51.938386 INFO::Creating boxplot for categorical data, diagnosis vs F81

## 2026-05-31 06:37:52.129381 INFO::Creating boxplot for categorical data, diagnosis vs F110

## 2026-05-31 06:37:52.313047 INFO::Creating boxplot for categorical data, diagnosis vs F3

## 2026-05-31 06:37:52.506424 INFO::Creating boxplot for categorical data, diagnosis vs F33

## 2026-05-31 06:37:52.688137 INFO::Creating boxplot for categorical data, diagnosis vs F270

## 2026-05-31 06:37:52.939953 INFO::Creating boxplot for categorical data, diagnosis vs F278

## 2026-05-31 06:37:53.125025 INFO::Creating boxplot for categorical data, diagnosis vs F264

## 2026-05-31 06:37:53.312778 INFO::Creating boxplot for categorical data, diagnosis vs F403

## 2026-05-31 06:37:53.50996 INFO::Creating boxplot for categorical data, diagnosis vs F90

## 2026-05-31 06:37:53.69431 INFO::Creating boxplot for categorical data, diagnosis vs F800

## 2026-05-31 06:37:53.876941 INFO::Creating boxplot for categorical data, diagnosis vs F394

## 2026-05-31 06:37:54.078178 INFO::Creating boxplot for categorical data, diagnosis vs F727

## 2026-05-31 06:37:54.26681 INFO::Creating boxplot for categorical data, diagnosis vs F439

## 2026-05-31 06:37:54.46103 INFO::Creating boxplot for categorical data, diagnosis vs F554

## 2026-05-31 06:37:54.644728 INFO::Creating boxplot for categorical data, diagnosis vs F559

## 2026-05-31 06:37:54.828312 INFO::Creating boxplot for categorical data, diagnosis vs F548

## 2026-05-31 06:37:55.023423 INFO::Creating boxplot for categorical data, diagnosis vs F794

## 2026-05-31 06:37:55.209846 INFO::Creating boxplot for categorical data, diagnosis vs F45

## 2026-05-31 06:37:55.393211 INFO::Creating boxplot for categorical data, diagnosis vs F158

## 2026-05-31 06:37:55.590266 INFO::Creating boxplot for categorical data, diagnosis vs F477

## 2026-05-31 06:37:55.776491 INFO::Creating boxplot for categorical data, diagnosis vs F862

## 2026-05-31 06:37:55.972435 INFO::Creating boxplot for categorical data, diagnosis vs F803

## 2026-05-31 06:37:56.158183 INFO::Creating boxplot for categorical data, diagnosis vs F751

## 2026-05-31 06:37:56.340906 INFO::Creating boxplot for categorical data, diagnosis vs F98

## 2026-05-31 06:37:56.536146 INFO::Creating boxplot for categorical data, diagnosis vs F22

## 2026-05-31 06:37:56.721096 INFO::Creating boxplot for categorical data, diagnosis vs F625

## 2026-05-31 06:37:56.917475 INFO::Creating boxplot for categorical data, diagnosis vs F779

## 2026-05-31 06:37:57.102688 INFO::Creating boxplot for categorical data, diagnosis vs F206

## 2026-05-31 06:37:57.286056 INFO::Creating boxplot for categorical data, diagnosis vs F532

## 2026-05-31 06:37:57.480915 INFO::Creating boxplot for categorical data, diagnosis vs F676

## 2026-05-31 06:37:57.666566 INFO::Creating boxplot for categorical data, diagnosis vs F644

## 2026-05-31 06:37:57.863379 INFO::Creating boxplot for categorical data, diagnosis vs F7

## 2026-05-31 06:37:58.049749 INFO::Creating boxplot for categorical data, diagnosis vs F596

## 2026-05-31 06:37:58.235377 INFO::Creating boxplot for categorical data, diagnosis vs F250

## 2026-05-31 06:37:58.4312 INFO::Creating boxplot for categorical data, diagnosis vs F462

## 2026-05-31 06:37:58.616384 INFO::Creating boxplot for categorical data, diagnosis vs F516

## 2026-05-31 06:37:58.813306 INFO::Creating boxplot for categorical data, diagnosis vs F659

## 2026-05-31 06:37:58.999763 INFO::Creating boxplot for categorical data, diagnosis vs F663

## 2026-05-31 06:37:59.185159 INFO::Creating boxplot for categorical data, diagnosis vs F837

## 2026-05-31 06:37:59.382877 INFO::Creating boxplot for categorical data, diagnosis vs F138

## 2026-05-31 06:37:59.569235 INFO::Creating boxplot for categorical data, diagnosis vs F445

## 2026-05-31 06:37:59.765495 INFO::Creating boxplot for categorical data, diagnosis vs F697

## 2026-05-31 06:37:59.952483 INFO::Creating boxplot for categorical data, diagnosis vs F225

## 2026-05-31 06:38:00.136539 INFO::Creating boxplot for categorical data, diagnosis vs F148

## 2026-05-31 06:38:00.33336 INFO::Creating boxplot for categorical data, diagnosis vs F448

## 2026-05-31 06:38:00.517722 INFO::Creating boxplot for categorical data, diagnosis vs F665

## 2026-05-31 06:38:00.712845 INFO::Creating boxplot for categorical data, diagnosis vs F123

## 2026-05-31 06:38:00.899366 INFO::Creating boxplot for categorical data, diagnosis vs F91

## 2026-05-31 06:38:01.095822 INFO::Creating boxplot for categorical data, diagnosis vs F845

## 2026-05-31 06:38:01.282665 INFO::Creating boxplot for categorical data, diagnosis vs F331

## 2026-05-31 06:38:01.46991 INFO::Creating boxplot for categorical data, diagnosis vs F361

## 2026-05-31 06:38:01.665239 INFO::Creating boxplot for categorical data, diagnosis vs F421

## 2026-05-31 06:38:01.852051 INFO::Creating boxplot for categorical data, diagnosis vs F277

## 2026-05-31 06:38:02.049254 INFO::Creating boxplot for categorical data, diagnosis vs F307

## 2026-05-31 06:38:02.23536 INFO::Creating boxplot for categorical data, diagnosis vs F503

## 2026-05-31 06:38:02.420399 INFO::Creating boxplot for categorical data, diagnosis vs F34

## 2026-05-31 06:38:02.619277 INFO::Creating boxplot for categorical data, diagnosis vs F649

## 2026-05-31 06:38:02.806849 INFO::Creating boxplot for categorical data, diagnosis vs F298

## 2026-05-31 06:38:03.651116 INFO::Creating boxplot for categorical data, diagnosis vs F461

## 2026-05-31 06:38:03.82541 INFO::Creating boxplot for categorical data, diagnosis vs F375

## 2026-05-31 06:38:03.9994 INFO::Creating boxplot for categorical data, diagnosis vs F242

## 2026-05-31 06:38:04.18002 INFO::Creating boxplot for categorical data, diagnosis vs F648

## 2026-05-31 06:38:04.354703 INFO::Creating boxplot for categorical data, diagnosis vs F724

## 2026-05-31 06:38:04.538365 INFO::Creating boxplot for categorical data, diagnosis vs F678

## 2026-05-31 06:38:04.713304 INFO::Creating boxplot for categorical data, diagnosis vs F261

## 2026-05-31 06:38:04.889429 INFO::Creating boxplot for categorical data, diagnosis vs F290

## 2026-05-31 06:38:05.073855 INFO::Creating boxplot for categorical data, diagnosis vs F743

## 2026-05-31 06:38:05.247547 INFO::Creating boxplot for categorical data, diagnosis vs F495

## 2026-05-31 06:38:05.431238 INFO::Creating boxplot for categorical data, diagnosis vs F825

## 2026-05-31 06:38:05.603942 INFO::Creating boxplot for categorical data, diagnosis vs F43

## 2026-05-31 06:38:05.778184 INFO::Creating boxplot for categorical data, diagnosis vs F714

## 2026-05-31 06:38:05.960884 INFO::Creating boxplot for categorical data, diagnosis vs F131

## 2026-05-31 06:38:06.134295 INFO::Creating boxplot for categorical data, diagnosis vs F150

## 2026-05-31 06:38:06.309689 INFO::Creating boxplot for categorical data, diagnosis vs F651

## 2026-05-31 06:38:06.492443 INFO::Creating boxplot for categorical data, diagnosis vs F798

## 2026-05-31 06:38:06.665829 INFO::Creating boxplot for categorical data, diagnosis vs F199

## 2026-05-31 06:38:06.848292 INFO::Creating boxplot for categorical data, diagnosis vs F289

## 2026-05-31 06:38:07.021836 INFO::Creating boxplot for categorical data, diagnosis vs F661

## 2026-05-31 06:38:07.197778 INFO::Creating boxplot for categorical data, diagnosis vs F406

## 2026-05-31 06:38:07.379615 INFO::Creating boxplot for categorical data, diagnosis vs F139

## 2026-05-31 06:38:07.554486 INFO::Creating boxplot for categorical data, diagnosis vs F506

## 2026-05-31 06:38:07.737255 INFO::Creating boxplot for categorical data, diagnosis vs F552

## 2026-05-31 06:38:07.911769 INFO::Creating boxplot for categorical data, diagnosis vs F430

## 2026-05-31 06:38:08.087037 INFO::Creating boxplot for categorical data, diagnosis vs F94

## 2026-05-31 06:38:08.270111 INFO::Creating boxplot for categorical data, diagnosis vs F639

## 2026-05-31 06:38:08.444468 INFO::Creating boxplot for categorical data, diagnosis vs F500

## 2026-05-31 06:38:08.628171 INFO::Creating boxplot for categorical data, diagnosis vs F609

## 2026-05-31 06:38:08.802656 INFO::Creating boxplot for categorical data, diagnosis vs F306

## 2026-05-31 06:38:08.977834 INFO::Creating boxplot for categorical data, diagnosis vs F507

## 2026-05-31 06:38:09.160745 INFO::Creating boxplot for categorical data, diagnosis vs F671

## 2026-05-31 06:38:09.335196 INFO::Creating boxplot for categorical data, diagnosis vs F894

## 2026-05-31 06:38:09.519881 INFO::Creating boxplot for categorical data, diagnosis vs F195

## 2026-05-31 06:38:09.693702 INFO::Creating boxplot for categorical data, diagnosis vs F345

## 2026-05-31 06:38:09.870891 INFO::Creating boxplot for categorical data, diagnosis vs F801

## 2026-05-31 06:38:10.053782 INFO::Creating boxplot for categorical data, diagnosis vs F194

## 2026-05-31 06:38:10.229253 INFO::Creating boxplot for categorical data, diagnosis vs F119

## 2026-05-31 06:38:10.412787 INFO::Creating boxplot for categorical data, diagnosis vs F231

## 2026-05-31 06:38:10.587321 INFO::Creating boxplot for categorical data, diagnosis vs F120

## 2026-05-31 06:38:10.763784 INFO::Creating boxplot for categorical data, diagnosis vs F311

## 2026-05-31 06:38:10.944161 INFO::Creating boxplot for categorical data, diagnosis vs F646

## 2026-05-31 06:38:11.118376 INFO::Creating boxplot for categorical data, diagnosis vs F814

## 2026-05-31 06:38:11.302558 INFO::Creating boxplot for categorical data, diagnosis vs F510

## 2026-05-31 06:38:11.47898 INFO::Creating boxplot for categorical data, diagnosis vs F398

## 2026-05-31 06:38:11.663469 INFO::Creating boxplot for categorical data, diagnosis vs F60

## 2026-05-31 06:38:11.838821 INFO::Creating boxplot for categorical data, diagnosis vs F153

## 2026-05-31 06:38:12.015967 INFO::Creating boxplot for categorical data, diagnosis vs F858

## 2026-05-31 06:38:12.198902 INFO::Creating boxplot for categorical data, diagnosis vs F684

## 2026-05-31 06:38:12.374013 INFO::Creating boxplot for categorical data, diagnosis vs F775

## 2026-05-31 06:38:12.55901 INFO::Creating boxplot for categorical data, diagnosis vs F384

## 2026-05-31 06:38:12.733798 INFO::Creating boxplot for categorical data, diagnosis vs F134

## 2026-05-31 06:38:12.911842 INFO::Creating boxplot for categorical data, diagnosis vs F670

## 2026-05-31 06:38:13.168167 INFO::Creating boxplot for categorical data, diagnosis vs F376

## 2026-05-31 06:38:13.353082 INFO::Creating boxplot for categorical data, diagnosis vs F632

## 2026-05-31 06:38:13.558113 INFO::Creating boxplot for categorical data, diagnosis vs F721

## 2026-05-31 06:38:13.745154 INFO::Creating boxplot for categorical data, diagnosis vs F700

## 2026-05-31 06:38:13.925673 INFO::Creating boxplot for categorical data, diagnosis vs F301

## 2026-05-31 06:38:14.123302 INFO::Creating boxplot for categorical data, diagnosis vs F27

## 2026-05-31 06:38:14.30644 INFO::Creating boxplot for categorical data, diagnosis vs F391

## 2026-05-31 06:38:14.498106 INFO::Creating boxplot for categorical data, diagnosis vs F725

## 2026-05-31 06:38:14.687156 INFO::Creating boxplot for categorical data, diagnosis vs F186

## 2026-05-31 06:38:14.871088 INFO::Creating boxplot for categorical data, diagnosis vs F481

## 2026-05-31 06:38:15.069253 INFO::Creating boxplot for categorical data, diagnosis vs F280

## 2026-05-31 06:38:15.253386 INFO::Creating boxplot for categorical data, diagnosis vs F333

## 2026-05-31 06:38:15.434437 INFO::Creating boxplot for categorical data, diagnosis vs F720

## 2026-05-31 06:38:15.633921 INFO::Creating boxplot for categorical data, diagnosis vs F520

## 2026-05-31 06:38:15.820382 INFO::Creating boxplot for categorical data, diagnosis vs F129

## 2026-05-31 06:38:16.019234 INFO::Creating boxplot for categorical data, diagnosis vs F204

## 2026-05-31 06:38:16.20386 INFO::Creating boxplot for categorical data, diagnosis vs F259

## 2026-05-31 06:38:16.38471 INFO::Creating boxplot for categorical data, diagnosis vs F831

## 2026-05-31 06:38:16.583591 INFO::Creating boxplot for categorical data, diagnosis vs F113

## 2026-05-31 06:38:16.766683 INFO::Creating boxplot for categorical data, diagnosis vs F891

## 2026-05-31 06:38:16.964327 INFO::Creating boxplot for categorical data, diagnosis vs F262

## 2026-05-31 06:38:17.148508 INFO::Creating boxplot for categorical data, diagnosis vs F592

## 2026-05-31 06:38:17.328355 INFO::Creating boxplot for categorical data, diagnosis vs F343

## 2026-05-31 06:38:17.52592 INFO::Creating boxplot for categorical data, diagnosis vs F505

## 2026-05-31 06:38:17.709816 INFO::Creating boxplot for categorical data, diagnosis vs F622

## 2026-05-31 06:38:17.908146 INFO::Creating boxplot for categorical data, diagnosis vs F348

## 2026-05-31 06:38:18.092395 INFO::Creating boxplot for categorical data, diagnosis vs F133

## 2026-05-31 06:38:18.273353 INFO::Creating boxplot for categorical data, diagnosis vs F371

## 2026-05-31 06:38:18.473104 INFO::Creating boxplot for categorical data, diagnosis vs F399

## 2026-05-31 06:38:18.65628 INFO::Creating boxplot for categorical data, diagnosis vs F657

## 2026-05-31 06:38:18.8551 INFO::Creating boxplot for categorical data, diagnosis vs F241

## 2026-05-31 06:38:19.039042 INFO::Creating boxplot for categorical data, diagnosis vs F95

## 2026-05-31 06:38:19.21945 INFO::Creating boxplot for categorical data, diagnosis vs F128

## 2026-05-31 06:38:19.418453 INFO::Creating boxplot for categorical data, diagnosis vs F595

## 2026-05-31 06:38:19.603451 INFO::Creating boxplot for categorical data, diagnosis vs F428

## 2026-05-31 06:38:19.80163 INFO::Creating boxplot for categorical data, diagnosis vs F796

## 2026-05-31 06:38:19.985854 INFO::Creating boxplot for categorical data, diagnosis vs F709

## 2026-05-31 06:38:20.167124 INFO::Creating boxplot for categorical data, diagnosis vs F336

## 2026-05-31 06:38:20.366601 INFO::Creating boxplot for categorical data, diagnosis vs F602

## 2026-05-31 06:38:20.550202 INFO::Creating boxplot for categorical data, diagnosis vs F108

## 2026-05-31 06:38:20.747918 INFO::Creating boxplot for categorical data, diagnosis vs F867

## 2026-05-31 06:38:20.930401 INFO::Creating boxplot for categorical data, diagnosis vs F293

## 2026-05-31 06:38:21.123356 INFO::Creating boxplot for categorical data, diagnosis vs F633

## 2026-05-31 06:38:21.313307 INFO::Creating boxplot for categorical data, diagnosis vs F564

## 2026-05-31 06:38:21.49504 INFO::Creating boxplot for categorical data, diagnosis vs F183

## 2026-05-31 06:38:21.694201 INFO::Creating boxplot for categorical data, diagnosis vs F647

## 2026-05-31 06:38:21.879766 INFO::Creating boxplot for categorical data, diagnosis vs F288

## 2026-05-31 06:38:22.079011 INFO::Creating boxplot for categorical data, diagnosis vs F159

## 2026-05-31 06:38:22.262236 INFO::Creating boxplot for categorical data, diagnosis vs F638

## 2026-05-31 06:38:22.442787 INFO::Creating boxplot for categorical data, diagnosis vs F484

## 2026-05-31 06:38:22.642328 INFO::Creating boxplot for categorical data, diagnosis vs F20

## 2026-05-31 06:38:22.824205 INFO::Creating boxplot for categorical data, diagnosis vs F19

## 2026-05-31 06:38:23.072098 INFO::Creating boxplot for categorical data, diagnosis vs F897

## 2026-05-31 06:38:23.261169 INFO::Creating boxplot for categorical data, diagnosis vs F442

## 2026-05-31 06:38:23.449456 INFO::Creating boxplot for categorical data, diagnosis vs F372

## 2026-05-31 06:38:23.658325 INFO::Creating boxplot for categorical data, diagnosis vs F771

## 2026-05-31 06:38:23.846117 INFO::Creating boxplot for categorical data, diagnosis vs F370

## 2026-05-31 06:38:24.056039 INFO::Creating boxplot for categorical data, diagnosis vs F620

## 2026-05-31 06:38:24.24187 INFO::Creating boxplot for categorical data, diagnosis vs F753

## 2026-05-31 06:38:24.429318 INFO::Creating boxplot for categorical data, diagnosis vs F568

## 2026-05-31 06:38:24.639422 INFO::Creating boxplot for categorical data, diagnosis vs F312

## 2026-05-31 06:38:24.828188 INFO::Creating boxplot for categorical data, diagnosis vs F485

## 2026-05-31 06:38:25.028295 INFO::Creating boxplot for categorical data, diagnosis vs F627

## 2026-05-31 06:38:25.226029 INFO::Creating boxplot for categorical data, diagnosis vs F72

## 2026-05-31 06:38:25.416327 INFO::Creating boxplot for categorical data, diagnosis vs F575

## 2026-05-31 06:38:25.627362 INFO::Creating boxplot for categorical data, diagnosis vs F332

## 2026-05-31 06:38:25.815859 INFO::Creating boxplot for categorical data, diagnosis vs F674

## 2026-05-31 06:38:26.003923 INFO::Creating boxplot for categorical data, diagnosis vs F537

## 2026-05-31 06:38:26.215434 INFO::Creating boxplot for categorical data, diagnosis vs F839

## 2026-05-31 06:38:26.406278 INFO::Creating boxplot for categorical data, diagnosis vs F768

## 2026-05-31 06:38:26.618025 INFO::Creating boxplot for categorical data, diagnosis vs F202

## 2026-05-31 06:38:26.806287 INFO::Creating boxplot for categorical data, diagnosis vs F715

## 2026-05-31 06:38:26.992998 INFO::Creating boxplot for categorical data, diagnosis vs F756

## 2026-05-31 06:38:27.202471 INFO::Creating boxplot for categorical data, diagnosis vs F536

## 2026-05-31 06:38:27.392302 INFO::Creating boxplot for categorical data, diagnosis vs F574

## 2026-05-31 06:38:27.602436 INFO::Creating boxplot for categorical data, diagnosis vs F435

## 2026-05-31 06:38:27.789739 INFO::Creating boxplot for categorical data, diagnosis vs F677

## 2026-05-31 06:38:27.977568 INFO::Creating boxplot for categorical data, diagnosis vs F70

## 2026-05-31 06:38:28.189565 INFO::Creating boxplot for categorical data, diagnosis vs F146

## 2026-05-31 06:38:28.378285 INFO::Creating boxplot for categorical data, diagnosis vs F236

## 2026-05-31 06:38:28.590531 INFO::Creating boxplot for categorical data, diagnosis vs F527

## 2026-05-31 06:38:28.777987 INFO::Creating boxplot for categorical data, diagnosis vs F624

## 2026-05-31 06:38:28.965089 INFO::Creating boxplot for categorical data, diagnosis vs F880

## 2026-05-31 06:38:29.175556 INFO::Creating boxplot for categorical data, diagnosis vs F426

## 2026-05-31 06:38:29.365619 INFO::Creating boxplot for categorical data, diagnosis vs F549

## 2026-05-31 06:38:29.581897 INFO::Creating boxplot for categorical data, diagnosis vs F49

## 2026-05-31 06:38:29.767938 INFO::Creating boxplot for categorical data, diagnosis vs F254

## 2026-05-31 06:38:29.952668 INFO::Creating boxplot for categorical data, diagnosis vs F67

## 2026-05-31 06:38:30.163109 INFO::Creating boxplot for categorical data, diagnosis vs F491

## 2026-05-31 06:38:30.353482 INFO::Creating boxplot for categorical data, diagnosis vs F174

## 2026-05-31 06:38:30.561958 INFO::Creating boxplot for categorical data, diagnosis vs F235

## 2026-05-31 06:38:30.745876 INFO::Creating boxplot for categorical data, diagnosis vs F112

## 2026-05-31 06:38:30.938841 INFO::Creating boxplot for categorical data, diagnosis vs F752

## 2026-05-31 06:38:31.140361 INFO::Creating boxplot for categorical data, diagnosis vs F833

## 2026-05-31 06:38:31.330393 INFO::Creating boxplot for categorical data, diagnosis vs F792

## 2026-05-31 06:38:31.541094 INFO::Creating boxplot for categorical data, diagnosis vs F422

## 2026-05-31 06:38:31.727478 INFO::Creating boxplot for categorical data, diagnosis vs F6

## 2026-05-31 06:38:31.934978 INFO::Creating boxplot for categorical data, diagnosis vs F706

## 2026-05-31 06:38:32.124 INFO::Creating boxplot for categorical data, diagnosis vs F463

## 2026-05-31 06:38:32.309856 INFO::Creating boxplot for categorical data, diagnosis vs F642

## 2026-05-31 06:38:32.521599 INFO::Creating boxplot for categorical data, diagnosis vs F102

## 2026-05-31 06:38:32.707991 INFO::Creating boxplot for categorical data, diagnosis vs F65

## 2026-05-31 06:38:32.918217 INFO::Creating boxplot for categorical data, diagnosis vs F889

## 2026-05-31 06:38:33.106581 INFO::Creating boxplot for categorical data, diagnosis vs F681

## 2026-05-31 06:38:33.378655 INFO::Creating boxplot for categorical data, diagnosis vs F783

## 2026-05-31 06:38:33.564951 INFO::Creating boxplot for categorical data, diagnosis vs F748

## 2026-05-31 06:38:33.758829 INFO::Creating boxplot for categorical data, diagnosis vs F478

## 2026-05-31 06:38:33.968365 INFO::Creating boxplot for categorical data, diagnosis vs F762

## 2026-05-31 06:38:34.154651 INFO::Creating boxplot for categorical data, diagnosis vs F852

## 2026-05-31 06:38:34.341703 INFO::Creating boxplot for categorical data, diagnosis vs F180

## 2026-05-31 06:38:34.550274 INFO::Creating boxplot for categorical data, diagnosis vs F759

## 2026-05-31 06:38:34.737445 INFO::Creating boxplot for categorical data, diagnosis vs F824

## 2026-05-31 06:38:34.945426 INFO::Creating boxplot for categorical data, diagnosis vs F248

## 2026-05-31 06:38:35.13095 INFO::Creating boxplot for categorical data, diagnosis vs F145

## 2026-05-31 06:38:35.319607 INFO::Creating boxplot for categorical data, diagnosis vs F350

## 2026-05-31 06:38:35.52527 INFO::Creating boxplot for categorical data, diagnosis vs F16

## 2026-05-31 06:38:35.714054 INFO::Creating boxplot for categorical data, diagnosis vs F169

## 2026-05-31 06:38:35.91866 INFO::Creating boxplot for categorical data, diagnosis vs F392

## 2026-05-31 06:38:36.111194 INFO::Creating boxplot for categorical data, diagnosis vs F468

## 2026-05-31 06:38:36.300147 INFO::Creating boxplot for categorical data, diagnosis vs F476

## 2026-05-31 06:38:36.508777 INFO::Creating boxplot for categorical data, diagnosis vs F699

## 2026-05-31 06:38:36.696325 INFO::Creating boxplot for categorical data, diagnosis vs F735

## 2026-05-31 06:38:36.884622 INFO::Creating boxplot for categorical data, diagnosis vs F182

## 2026-05-31 06:38:37.093001 INFO::Creating boxplot for categorical data, diagnosis vs F203

## 2026-05-31 06:38:37.281553 INFO::Creating boxplot for categorical data, diagnosis vs F877

## 2026-05-31 06:38:37.489226 INFO::Creating boxplot for categorical data, diagnosis vs F433

## 2026-05-31 06:38:37.677785 INFO::Creating boxplot for categorical data, diagnosis vs F739

## 2026-05-31 06:38:37.866978 INFO::Creating boxplot for categorical data, diagnosis vs F749

## 2026-05-31 06:38:38.074142 INFO::Creating boxplot for categorical data, diagnosis vs F382

## 2026-05-31 06:38:38.262233 INFO::Creating boxplot for categorical data, diagnosis vs F438

## 2026-05-31 06:38:38.470404 INFO::Creating boxplot for categorical data, diagnosis vs F360

## 2026-05-31 06:38:38.659755 INFO::Creating boxplot for categorical data, diagnosis vs F56

## 2026-05-31 06:38:38.849122 INFO::Creating boxplot for categorical data, diagnosis vs F48

## 2026-05-31 06:38:39.058348 INFO::Creating boxplot for categorical data, diagnosis vs F162

## 2026-05-31 06:38:39.248548 INFO::Creating boxplot for categorical data, diagnosis vs F529

## 2026-05-31 06:38:39.457699 INFO::Creating boxplot for categorical data, diagnosis vs F826

## 2026-05-31 06:38:39.646773 INFO::Creating boxplot for categorical data, diagnosis vs F488

## 2026-05-31 06:38:39.837976 INFO::Creating boxplot for categorical data, diagnosis vs F309

## 2026-05-31 06:38:40.044855 INFO::Creating boxplot for categorical data, diagnosis vs F834

## 2026-05-31 06:38:40.235542 INFO::Creating boxplot for categorical data, diagnosis vs F449

## 2026-05-31 06:38:40.441905 INFO::Creating boxplot for categorical data, diagnosis vs F77

## 2026-05-31 06:38:40.628999 INFO::Creating boxplot for categorical data, diagnosis vs F365

## 2026-05-31 06:38:40.834445 INFO::Creating boxplot for categorical data, diagnosis vs F346

## 2026-05-31 06:38:41.026199 INFO::Creating boxplot for categorical data, diagnosis vs F654

## 2026-05-31 06:38:41.228101 INFO::Creating boxplot for categorical data, diagnosis vs F64

## 2026-05-31 06:38:41.432018 INFO::Creating boxplot for categorical data, diagnosis vs F79

## 2026-05-31 06:38:41.620756 INFO::Creating boxplot for categorical data, diagnosis vs F785

## 2026-05-31 06:38:41.827523 INFO::Creating boxplot for categorical data, diagnosis vs F415

## 2026-05-31 06:38:42.013937 INFO::Creating boxplot for categorical data, diagnosis vs F466

## 2026-05-31 06:38:42.202195 INFO::Creating boxplot for categorical data, diagnosis vs F643

## 2026-05-31 06:38:42.40945 INFO::Creating boxplot for categorical data, diagnosis vs F160

## 2026-05-31 06:38:42.600595 INFO::Creating boxplot for categorical data, diagnosis vs F69

## 2026-05-31 06:38:42.80696 INFO::Creating boxplot for categorical data, diagnosis vs F498

## 2026-05-31 06:38:42.996017 INFO::Creating boxplot for categorical data, diagnosis vs F207

## 2026-05-31 06:38:43.203304 INFO::Creating boxplot for categorical data, diagnosis vs F679

## 2026-05-31 06:38:43.390301 INFO::Creating boxplot for categorical data, diagnosis vs F255

## 2026-05-31 06:38:43.578936 INFO::Creating boxplot for categorical data, diagnosis vs F267

## 2026-05-31 06:38:43.844445 INFO::Creating boxplot for categorical data, diagnosis vs F143

## 2026-05-31 06:38:44.034825 INFO::Creating boxplot for categorical data, diagnosis vs F286

## 2026-05-31 06:38:44.245326 INFO::Creating boxplot for categorical data, diagnosis vs F618

## 2026-05-31 06:38:44.441387 INFO::Creating boxplot for categorical data, diagnosis vs F100

## 2026-05-31 06:38:44.634055 INFO::Creating boxplot for categorical data, diagnosis vs F562

## 2026-05-31 06:38:44.852739 INFO::Creating boxplot for categorical data, diagnosis vs F374

## 2026-05-31 06:38:45.043569 INFO::Creating boxplot for categorical data, diagnosis vs F535

## 2026-05-31 06:38:45.235402 INFO::Creating boxplot for categorical data, diagnosis vs F658

## 2026-05-31 06:38:45.452662 INFO::Creating boxplot for categorical data, diagnosis vs F707

## 2026-05-31 06:38:45.642664 INFO::Creating boxplot for categorical data, diagnosis vs F214

## 2026-05-31 06:38:45.861016 INFO::Creating boxplot for categorical data, diagnosis vs F89

## 2026-05-31 06:38:46.049561 INFO::Creating boxplot for categorical data, diagnosis vs F325

## 2026-05-31 06:38:46.238857 INFO::Creating boxplot for categorical data, diagnosis vs F578

## 2026-05-31 06:38:46.457438 INFO::Creating boxplot for categorical data, diagnosis vs F790

## 2026-05-31 06:38:46.648403 INFO::Creating boxplot for categorical data, diagnosis vs F265

## 2026-05-31 06:38:46.864939 INFO::Creating boxplot for categorical data, diagnosis vs F253

## 2026-05-31 06:38:47.059214 INFO::Creating boxplot for categorical data, diagnosis vs F294

## 2026-05-31 06:38:47.249582 INFO::Creating boxplot for categorical data, diagnosis vs F410

## 2026-05-31 06:38:47.469403 INFO::Creating boxplot for categorical data, diagnosis vs F764

## 2026-05-31 06:38:47.659737 INFO::Creating boxplot for categorical data, diagnosis vs F614

## 2026-05-31 06:38:47.866584 INFO::Creating boxplot for categorical data, diagnosis vs F675

## 2026-05-31 06:38:48.068651 INFO::Creating boxplot for categorical data, diagnosis vs F193

## 2026-05-31 06:38:48.258429 INFO::Creating boxplot for categorical data, diagnosis vs F441

## 2026-05-31 06:38:48.479213 INFO::Creating boxplot for categorical data, diagnosis vs F689

## 2026-05-31 06:38:48.669807 INFO::Creating boxplot for categorical data, diagnosis vs F249

## 2026-05-31 06:38:48.876257 INFO::Creating boxplot for categorical data, diagnosis vs F821

## 2026-05-31 06:38:49.08254 INFO::Creating boxplot for categorical data, diagnosis vs F351

## 2026-05-31 06:38:49.273623 INFO::Creating boxplot for categorical data, diagnosis vs F66

## 2026-05-31 06:38:49.493678 INFO::Creating boxplot for categorical data, diagnosis vs F172

## 2026-05-31 06:38:49.684882 INFO::Creating boxplot for categorical data, diagnosis vs F413

## 2026-05-31 06:38:49.894644 INFO::Creating boxplot for categorical data, diagnosis vs F317

## 2026-05-31 06:38:50.09783 INFO::Creating boxplot for categorical data, diagnosis vs F167

## 2026-05-31 06:38:50.291387 INFO::Creating boxplot for categorical data, diagnosis vs F229

## 2026-05-31 06:38:50.508764 INFO::Creating boxplot for categorical data, diagnosis vs F243

## 2026-05-31 06:38:50.700581 INFO::Creating boxplot for categorical data, diagnosis vs F732

## 2026-05-31 06:38:50.919523 INFO::Creating boxplot for categorical data, diagnosis vs F467

## 2026-05-31 06:38:51.109847 INFO::Creating boxplot for categorical data, diagnosis vs F474

## 2026-05-31 06:38:51.304695 INFO::Creating boxplot for categorical data, diagnosis vs F156

## 2026-05-31 06:38:51.521518 INFO::Creating boxplot for categorical data, diagnosis vs F786

## 2026-05-31 06:38:51.712129 INFO::Creating boxplot for categorical data, diagnosis vs F216

## 2026-05-31 06:38:51.930517 INFO::Creating boxplot for categorical data, diagnosis vs F85

## 2026-05-31 06:38:52.119811 INFO::Creating boxplot for categorical data, diagnosis vs F558

## 2026-05-31 06:38:52.321109 INFO::Creating boxplot for categorical data, diagnosis vs F621

## 2026-05-31 06:38:52.529336 INFO::Creating boxplot for categorical data, diagnosis vs F582

## 2026-05-31 06:38:52.720476 INFO::Creating boxplot for categorical data, diagnosis vs F898

## 2026-05-31 06:38:52.940539 INFO::Creating boxplot for categorical data, diagnosis vs F402

## 2026-05-31 06:38:53.132557 INFO::Creating boxplot for categorical data, diagnosis vs F71

## 2026-05-31 06:38:53.351111 INFO::Creating boxplot for categorical data, diagnosis vs F99

## 2026-05-31 06:38:53.541881 INFO::Creating boxplot for categorical data, diagnosis vs F188

## 2026-05-31 06:38:53.731393 INFO::Creating boxplot for categorical data, diagnosis vs F366

## 2026-05-31 06:38:53.949078 INFO::Creating boxplot for categorical data, diagnosis vs F778

## 2026-05-31 06:38:54.143963 INFO::Creating boxplot for categorical data, diagnosis vs F857

## 2026-05-31 06:38:54.429118 INFO::Creating boxplot for categorical data, diagnosis vs F440

## 2026-05-31 06:38:54.622154 INFO::Creating boxplot for categorical data, diagnosis vs F799

## 2026-05-31 06:38:54.817544 INFO::Creating boxplot for categorical data, diagnosis vs F482

## 2026-05-31 06:38:55.030931 INFO::Creating boxplot for categorical data, diagnosis vs F212

## 2026-05-31 06:38:55.2213 INFO::Creating boxplot for categorical data, diagnosis vs F882

## 2026-05-31 06:38:55.437372 INFO::Creating boxplot for categorical data, diagnosis vs F599

## 2026-05-31 06:38:55.629527 INFO::Creating boxplot for categorical data, diagnosis vs F302

## 2026-05-31 06:38:55.820539 INFO::Creating boxplot for categorical data, diagnosis vs F543

## 2026-05-31 06:38:56.035842 INFO::Creating boxplot for categorical data, diagnosis vs F269

## 2026-05-31 06:38:56.229402 INFO::Creating boxplot for categorical data, diagnosis vs F650

## 2026-05-31 06:38:56.440254 INFO::Creating boxplot for categorical data, diagnosis vs F573

## 2026-05-31 06:38:56.636116 INFO::Creating boxplot for categorical data, diagnosis vs F8

## 2026-05-31 06:38:56.829586 INFO::Creating boxplot for categorical data, diagnosis vs F810

## 2026-05-31 06:38:57.044297 INFO::Creating boxplot for categorical data, diagnosis vs F456

## 2026-05-31 06:38:57.23513 INFO::Creating boxplot for categorical data, diagnosis vs F37

## 2026-05-31 06:38:57.425212 INFO::Creating boxplot for categorical data, diagnosis vs F401

## 2026-05-31 06:38:57.640266 INFO::Creating boxplot for categorical data, diagnosis vs F871

## 2026-05-31 06:38:57.83321 INFO::Creating boxplot for categorical data, diagnosis vs F606

## 2026-05-31 06:38:58.047857 INFO::Creating boxplot for categorical data, diagnosis vs F662

## 2026-05-31 06:38:58.24042 INFO::Creating boxplot for categorical data, diagnosis vs F887

## 2026-05-31 06:38:58.431454 INFO::Creating boxplot for categorical data, diagnosis vs F765

## 2026-05-31 06:38:58.645722 INFO::Creating boxplot for categorical data, diagnosis vs F770

## 2026-05-31 06:38:58.837521 INFO::Creating boxplot for categorical data, diagnosis vs F469

## 2026-05-31 06:38:59.054837 INFO::Creating boxplot for categorical data, diagnosis vs F86

## 2026-05-31 06:38:59.247193 INFO::Creating boxplot for categorical data, diagnosis vs F579

## 2026-05-31 06:38:59.438327 INFO::Creating boxplot for categorical data, diagnosis vs F400

## 2026-05-31 06:38:59.652382 INFO::Creating boxplot for categorical data, diagnosis vs F446

## 2026-05-31 06:38:59.846043 INFO::Creating boxplot for categorical data, diagnosis vs F321

## 2026-05-31 06:39:00.061046 INFO::Creating boxplot for categorical data, diagnosis vs F218

## 2026-05-31 06:39:00.254852 INFO::Creating boxplot for categorical data, diagnosis vs F141

## 2026-05-31 06:39:00.445053 INFO::Creating boxplot for categorical data, diagnosis vs F487

## 2026-05-31 06:39:00.661214 INFO::Creating boxplot for categorical data, diagnosis vs F740

## 2026-05-31 06:39:00.855112 INFO::Creating boxplot for categorical data, diagnosis vs F327

## 2026-05-31 06:39:01.069884 INFO::Creating boxplot for categorical data, diagnosis vs F196

## 2026-05-31 06:39:01.268731 INFO::Creating boxplot for categorical data, diagnosis vs F883

## 2026-05-31 06:39:01.466728 INFO::Creating boxplot for categorical data, diagnosis vs F279

## 2026-05-31 06:39:01.682881 INFO::Creating boxplot for categorical data, diagnosis vs F451

## 2026-05-31 06:39:01.877035 INFO::Creating boxplot for categorical data, diagnosis vs F838

## 2026-05-31 06:39:02.092861 INFO::Creating boxplot for categorical data, diagnosis vs F854

## 2026-05-31 06:39:02.283936 INFO::Creating boxplot for categorical data, diagnosis vs F434

## 2026-05-31 06:39:02.493778 INFO::Creating boxplot for categorical data, diagnosis vs F519

## 2026-05-31 06:39:02.689827 INFO::Creating boxplot for categorical data, diagnosis vs F694

## 2026-05-31 06:39:02.883225 INFO::Creating boxplot for categorical data, diagnosis vs F561

## 2026-05-31 06:39:03.096731 INFO::Creating boxplot for categorical data, diagnosis vs F10

## 2026-05-31 06:39:03.290425 INFO::Creating boxplot for categorical data, diagnosis vs F303

## 2026-05-31 06:39:03.504632 INFO::Creating boxplot for categorical data, diagnosis vs F645

## 2026-05-31 06:39:03.695227 INFO::Creating boxplot for categorical data, diagnosis vs F793

## 2026-05-31 06:39:03.887854 INFO::Creating boxplot for categorical data, diagnosis vs F404

## 2026-05-31 06:39:04.102274 INFO::Creating boxplot for categorical data, diagnosis vs F525

## 2026-05-31 06:39:04.294493 INFO::Creating boxplot for categorical data, diagnosis vs F362

## 2026-05-31 06:39:04.50845 INFO::Creating boxplot for categorical data, diagnosis vs F742

## 2026-05-31 06:39:04.700891 INFO::Creating boxplot for categorical data, diagnosis vs F276

## 2026-05-31 06:39:05.54941 INFO::Creating boxplot for categorical data, diagnosis vs F512

## 2026-05-31 06:39:05.721125 INFO::Creating boxplot for categorical data, diagnosis vs F499

## 2026-05-31 06:39:05.894268 INFO::Creating boxplot for categorical data, diagnosis vs F328

## 2026-05-31 06:39:06.075866 INFO::Creating boxplot for categorical data, diagnosis vs F787

## 2026-05-31 06:39:06.249327 INFO::Creating boxplot for categorical data, diagnosis vs F30

## 2026-05-31 06:39:06.423101 INFO::Creating boxplot for categorical data, diagnosis vs F122

## 2026-05-31 06:39:06.60212 INFO::Creating boxplot for categorical data, diagnosis vs F572

## 2026-05-31 06:39:06.774825 INFO::Creating boxplot for categorical data, diagnosis vs F619

## 2026-05-31 06:39:06.957109 INFO::Creating boxplot for categorical data, diagnosis vs F570

## 2026-05-31 06:39:07.127685 INFO::Creating boxplot for categorical data, diagnosis vs F47

## 2026-05-31 06:39:07.300616 INFO::Creating boxplot for categorical data, diagnosis vs F26

## 2026-05-31 06:39:07.479532 INFO::Creating boxplot for categorical data, diagnosis vs F252

## 2026-05-31 06:39:07.652211 INFO::Creating boxplot for categorical data, diagnosis vs F117

## 2026-05-31 06:39:07.833481 INFO::Creating boxplot for categorical data, diagnosis vs F395

## 2026-05-31 06:39:08.005989 INFO::Creating boxplot for categorical data, diagnosis vs F683

## 2026-05-31 06:39:08.178617 INFO::Creating boxplot for categorical data, diagnosis vs F822

## 2026-05-31 06:39:08.358675 INFO::Creating boxplot for categorical data, diagnosis vs F46

## 2026-05-31 06:39:08.52989 INFO::Creating boxplot for categorical data, diagnosis vs F154

## 2026-05-31 06:39:08.704153 INFO::Creating boxplot for categorical data, diagnosis vs F884

## 2026-05-31 06:39:08.883178 INFO::Creating boxplot for categorical data, diagnosis vs F540

## 2026-05-31 06:39:09.056938 INFO::Creating boxplot for categorical data, diagnosis vs F368

## 2026-05-31 06:39:09.239526 INFO::Creating boxplot for categorical data, diagnosis vs F607

## 2026-05-31 06:39:09.411886 INFO::Creating boxplot for categorical data, diagnosis vs F111

## 2026-05-31 06:39:09.586899 INFO::Creating boxplot for categorical data, diagnosis vs F745

## 2026-05-31 06:39:09.766428 INFO::Creating boxplot for categorical data, diagnosis vs F673

## 2026-05-31 06:39:09.940764 INFO::Creating boxplot for categorical data, diagnosis vs F92

## 2026-05-31 06:39:10.123081 INFO::Creating boxplot for categorical data, diagnosis vs F493

## 2026-05-31 06:39:10.295772 INFO::Creating boxplot for categorical data, diagnosis vs F518

## 2026-05-31 06:39:10.471146 INFO::Creating boxplot for categorical data, diagnosis vs F835

## 2026-05-31 06:39:10.652161 INFO::Creating boxplot for categorical data, diagnosis vs F872

## 2026-05-31 06:39:10.825854 INFO::Creating boxplot for categorical data, diagnosis vs F879

## 2026-05-31 06:39:11.006041 INFO::Creating boxplot for categorical data, diagnosis vs F432

## 2026-05-31 06:39:11.179727 INFO::Creating boxplot for categorical data, diagnosis vs F44

## 2026-05-31 06:39:11.354188 INFO::Creating boxplot for categorical data, diagnosis vs F819

## 2026-05-31 06:39:11.535023 INFO::Creating boxplot for categorical data, diagnosis vs F411

## 2026-05-31 06:39:11.70961 INFO::Creating boxplot for categorical data, diagnosis vs F353

## 2026-05-31 06:39:11.892647 INFO::Creating boxplot for categorical data, diagnosis vs F763

## 2026-05-31 06:39:12.065434 INFO::Creating boxplot for categorical data, diagnosis vs F40

## 2026-05-31 06:39:12.240855 INFO::Creating boxplot for categorical data, diagnosis vs F97

## 2026-05-31 06:39:12.418896 INFO::Creating boxplot for categorical data, diagnosis vs F240

## 2026-05-31 06:39:12.591687 INFO::Creating boxplot for categorical data, diagnosis vs F652

## 2026-05-31 06:39:12.773663 INFO::Creating boxplot for categorical data, diagnosis vs F789

## 2026-05-31 06:39:12.948094 INFO::Creating boxplot for categorical data, diagnosis vs F256

## 2026-05-31 06:39:13.131496 INFO::Creating boxplot for categorical data, diagnosis vs F25

## 2026-05-31 06:39:13.303635 INFO::Creating boxplot for categorical data, diagnosis vs F423

## 2026-05-31 06:39:13.479028 INFO::Creating boxplot for categorical data, diagnosis vs F594

## 2026-05-31 06:39:13.660981 INFO::Creating boxplot for categorical data, diagnosis vs F201

## 2026-05-31 06:39:13.838363 INFO::Creating boxplot for categorical data, diagnosis vs F813

## 2026-05-31 06:39:14.034208 INFO::Creating boxplot for categorical data, diagnosis vs F653

## 2026-05-31 06:39:14.227971 INFO::Creating boxplot for categorical data, diagnosis vs F524

## 2026-05-31 06:39:14.403379 INFO::Creating boxplot for categorical data, diagnosis vs F777

## 2026-05-31 06:39:14.584606 INFO::Creating boxplot for categorical data, diagnosis vs F226

## 2026-05-31 06:39:14.75949 INFO::Creating boxplot for categorical data, diagnosis vs F227

## 2026-05-31 06:39:15.009221 INFO::Creating boxplot for categorical data, diagnosis vs F521

## 2026-05-31 06:39:15.192289 INFO::Creating boxplot for categorical data, diagnosis vs F310

## 2026-05-31 06:39:15.376271 INFO::Creating boxplot for categorical data, diagnosis vs F452

## 2026-05-31 06:39:15.574616 INFO::Creating boxplot for categorical data, diagnosis vs F14

## 2026-05-31 06:39:15.754759 INFO::Creating boxplot for categorical data, diagnosis vs F52

## 2026-05-31 06:39:15.95046 INFO::Creating boxplot for categorical data, diagnosis vs F53

## 2026-05-31 06:39:16.134088 INFO::Creating boxplot for categorical data, diagnosis vs F844

## 2026-05-31 06:39:16.31365 INFO::Creating boxplot for categorical data, diagnosis vs F31

## 2026-05-31 06:39:16.510217 INFO::Creating boxplot for categorical data, diagnosis vs F766

## 2026-05-31 06:39:16.692298 INFO::Creating boxplot for categorical data, diagnosis vs F795

## 2026-05-31 06:39:16.892444 INFO::Creating boxplot for categorical data, diagnosis vs F342

## 2026-05-31 06:39:17.077158 INFO::Creating boxplot for categorical data, diagnosis vs F282

## 2026-05-31 06:39:17.256469 INFO::Creating boxplot for categorical data, diagnosis vs F508

## 2026-05-31 06:39:17.453048 INFO::Creating boxplot for categorical data, diagnosis vs F408

## 2026-05-31 06:39:17.636036 INFO::Creating boxplot for categorical data, diagnosis vs F805

## 2026-05-31 06:39:17.816369 INFO::Creating boxplot for categorical data, diagnosis vs F337

## 2026-05-31 06:39:18.015398 INFO::Creating boxplot for categorical data, diagnosis vs F820

## 2026-05-31 06:39:18.195928 INFO::Creating boxplot for categorical data, diagnosis vs F593

## 2026-05-31 06:39:18.393225 INFO::Creating boxplot for categorical data, diagnosis vs F459

## 2026-05-31 06:39:18.574636 INFO::Creating boxplot for categorical data, diagnosis vs F701

## 2026-05-31 06:39:18.755664 INFO::Creating boxplot for categorical data, diagnosis vs F142

## 2026-05-31 06:39:18.953204 INFO::Creating boxplot for categorical data, diagnosis vs F305

## 2026-05-31 06:39:19.1358 INFO::Creating boxplot for categorical data, diagnosis vs F534

## 2026-05-31 06:39:19.332226 INFO::Creating boxplot for categorical data, diagnosis vs F135

## 2026-05-31 06:39:19.515343 INFO::Creating boxplot for categorical data, diagnosis vs F702

## 2026-05-31 06:39:19.695573 INFO::Creating boxplot for categorical data, diagnosis vs F776

## 2026-05-31 06:39:19.894132 INFO::Creating boxplot for categorical data, diagnosis vs F295

## 2026-05-31 06:39:20.07766 INFO::Creating boxplot for categorical data, diagnosis vs F355

## 2026-05-31 06:39:20.272339 INFO::Creating boxplot for categorical data, diagnosis vs F797

## 2026-05-31 06:39:20.454768 INFO::Creating boxplot for categorical data, diagnosis vs F13

## 2026-05-31 06:39:20.633624 INFO::Creating boxplot for categorical data, diagnosis vs F356

## 2026-05-31 06:39:20.834337 INFO::Creating boxplot for categorical data, diagnosis vs F359

## 2026-05-31 06:39:21.014733 INFO::Creating boxplot for categorical data, diagnosis vs F121

## 2026-05-31 06:39:21.211 INFO::Creating boxplot for categorical data, diagnosis vs F850

## 2026-05-31 06:39:21.392802 INFO::Creating boxplot for categorical data, diagnosis vs F899

## 2026-05-31 06:39:21.573969 INFO::Creating boxplot for categorical data, diagnosis vs F628

## 2026-05-31 06:39:21.771482 INFO::Creating boxplot for categorical data, diagnosis vs F107

## 2026-05-31 06:39:21.95247 INFO::Creating boxplot for categorical data, diagnosis vs F287

## 2026-05-31 06:39:22.149826 INFO::Creating boxplot for categorical data, diagnosis vs F557

## 2026-05-31 06:39:22.333048 INFO::Creating boxplot for categorical data, diagnosis vs F165

## 2026-05-31 06:39:22.524781 INFO::Creating boxplot for categorical data, diagnosis vs F127

## 2026-05-31 06:39:22.710557 INFO::Creating boxplot for categorical data, diagnosis vs F299

## 2026-05-31 06:39:22.890865 INFO::Creating boxplot for categorical data, diagnosis vs F497

## 2026-05-31 06:39:23.087408 INFO::Creating boxplot for categorical data, diagnosis vs F711

## 2026-05-31 06:39:23.269676 INFO::Creating boxplot for categorical data, diagnosis vs F319

## 2026-05-31 06:39:23.464093 INFO::Creating boxplot for categorical data, diagnosis vs F271

## 2026-05-31 06:39:23.645178 INFO::Creating boxplot for categorical data, diagnosis vs F157

## 2026-05-31 06:39:23.823927 INFO::Creating boxplot for categorical data, diagnosis vs F560

## 2026-05-31 06:39:24.022361 INFO::Creating boxplot for categorical data, diagnosis vs F680

## 2026-05-31 06:39:24.203447 INFO::Creating boxplot for categorical data, diagnosis vs F580

## 2026-05-31 06:39:24.400859 INFO::Creating boxplot for categorical data, diagnosis vs F152

## 2026-05-31 06:39:24.581745 INFO::Creating boxplot for categorical data, diagnosis vs F12

## 2026-05-31 06:39:24.820904 INFO::Creating boxplot for categorical data, diagnosis vs F324

## 2026-05-31 06:39:25.01076 INFO::Creating boxplot for categorical data, diagnosis vs F893

## 2026-05-31 06:39:25.199909 INFO::Creating boxplot for categorical data, diagnosis vs F318

## 2026-05-31 06:39:25.407787 INFO::Creating boxplot for categorical data, diagnosis vs F784

## 2026-05-31 06:39:25.593731 INFO::Creating boxplot for categorical data, diagnosis vs F567

## 2026-05-31 06:39:25.779896 INFO::Creating boxplot for categorical data, diagnosis vs F457

## 2026-05-31 06:39:25.988445 INFO::Creating boxplot for categorical data, diagnosis vs F708

## 2026-05-31 06:39:26.175756 INFO::Creating boxplot for categorical data, diagnosis vs F669

## 2026-05-31 06:39:26.382975 INFO::Creating boxplot for categorical data, diagnosis vs F87

## 2026-05-31 06:39:26.569042 INFO::Creating boxplot for categorical data, diagnosis vs F730

## 2026-05-31 06:39:28.806739 INFO::Plotting data for metadata number 2, antibiotics
## 2026-05-31 06:39:28.808178 INFO::Creating boxplot for categorical data, antibiotics vs F663

## 2026-05-31 06:39:28.999298 INFO::Creating boxplot for categorical data, antibiotics vs F838

## 2026-05-31 06:39:29.215537 INFO::Creating boxplot for categorical data, antibiotics vs F764

## 2026-05-31 06:39:29.41129 INFO::Creating boxplot for categorical data, antibiotics vs F880

## 2026-05-31 06:39:29.627055 INFO::Creating boxplot for categorical data, antibiotics vs F751

## 2026-05-31 06:39:29.8215 INFO::Creating boxplot for categorical data, antibiotics vs F288

## 2026-05-31 06:39:30.02825 INFO::Creating boxplot for categorical data, antibiotics vs F65

## 2026-05-31 06:39:30.231343 INFO::Creating boxplot for categorical data, antibiotics vs F742

## 2026-05-31 06:39:30.425212 INFO::Creating boxplot for categorical data, antibiotics vs F528

## 2026-05-31 06:39:30.641486 INFO::Creating boxplot for categorical data, antibiotics vs F790

## 2026-05-31 06:39:30.837511 INFO::Creating boxplot for categorical data, antibiotics vs F777

## 2026-05-31 06:39:31.056733 INFO::Creating boxplot for categorical data, antibiotics vs F178

## 2026-05-31 06:39:31.251118 INFO::Creating boxplot for categorical data, antibiotics vs F139

## 2026-05-31 06:39:31.442199 INFO::Creating boxplot for categorical data, antibiotics vs F202

## 2026-05-31 06:39:31.66102 INFO::Creating boxplot for categorical data, antibiotics vs F220

## 2026-05-31 06:39:31.854964 INFO::Creating boxplot for categorical data, antibiotics vs F397

## 2026-05-31 06:39:32.069986 INFO::Creating boxplot for categorical data, antibiotics vs F882

## 2026-05-31 06:39:32.264217 INFO::Creating boxplot for categorical data, antibiotics vs F446

## 2026-05-31 06:39:32.478517 INFO::Creating boxplot for categorical data, antibiotics vs F418

## 2026-05-31 06:39:32.672048 INFO::Creating boxplot for categorical data, antibiotics vs F133

## 2026-05-31 06:39:32.872847 INFO::Creating boxplot for categorical data, antibiotics vs F696

## 2026-05-31 06:39:33.080414 INFO::Creating boxplot for categorical data, antibiotics vs F548

## 2026-05-31 06:39:33.273665 INFO::Creating boxplot for categorical data, antibiotics vs F536

## 2026-05-31 06:39:33.487659 INFO::Creating boxplot for categorical data, antibiotics vs F194

## 2026-05-31 06:39:33.681206 INFO::Creating boxplot for categorical data, antibiotics vs F34

## 2026-05-31 06:39:33.895304 INFO::Creating boxplot for categorical data, antibiotics vs F153

## 2026-05-31 06:39:34.089218 INFO::Creating boxplot for categorical data, antibiotics vs F400

## 2026-05-31 06:39:34.30087 INFO::Creating boxplot for categorical data, antibiotics vs F794

## 2026-05-31 06:39:34.496976 INFO::Creating boxplot for categorical data, antibiotics vs F396

## 2026-05-31 06:39:34.688014 INFO::Creating boxplot for categorical data, antibiotics vs F182

## 2026-05-31 06:39:34.905959 INFO::Creating boxplot for categorical data, antibiotics vs F719

## 2026-05-31 06:39:35.100228 INFO::Creating boxplot for categorical data, antibiotics vs F180

## 2026-05-31 06:39:35.316286 INFO::Creating boxplot for categorical data, antibiotics vs F552

## 2026-05-31 06:39:35.510146 INFO::Creating boxplot for categorical data, antibiotics vs F789

## 2026-05-31 06:39:35.803658 INFO::Creating boxplot for categorical data, antibiotics vs F893

## 2026-05-31 06:39:36.003388 INFO::Creating boxplot for categorical data, antibiotics vs F834

## 2026-05-31 06:39:36.218642 INFO::Creating boxplot for categorical data, antibiotics vs F889

## 2026-05-31 06:39:36.421992 INFO::Creating boxplot for categorical data, antibiotics vs F143

## 2026-05-31 06:39:36.618501 INFO::Creating boxplot for categorical data, antibiotics vs F224

## 2026-05-31 06:39:36.83475 INFO::Creating boxplot for categorical data, antibiotics vs F109

## 2026-05-31 06:39:37.031388 INFO::Creating boxplot for categorical data, antibiotics vs F5

## 2026-05-31 06:39:37.246969 INFO::Creating boxplot for categorical data, antibiotics vs F873

## 2026-05-31 06:39:37.443688 INFO::Creating boxplot for categorical data, antibiotics vs F681

## 2026-05-31 06:39:37.641077 INFO::Creating boxplot for categorical data, antibiotics vs F452

## 2026-05-31 06:39:37.857946 INFO::Creating boxplot for categorical data, antibiotics vs F468

## 2026-05-31 06:39:38.05569 INFO::Creating boxplot for categorical data, antibiotics vs F731

## 2026-05-31 06:39:38.272284 INFO::Creating boxplot for categorical data, antibiotics vs F479

## 2026-05-31 06:39:38.469037 INFO::Creating boxplot for categorical data, antibiotics vs F520

## 2026-05-31 06:39:38.683328 INFO::Creating boxplot for categorical data, antibiotics vs F649

## 2026-05-31 06:39:38.883141 INFO::Creating boxplot for categorical data, antibiotics vs F259

## 2026-05-31 06:39:39.079938 INFO::Creating boxplot for categorical data, antibiotics vs F186

## 2026-05-31 06:39:39.29548 INFO::Creating boxplot for categorical data, antibiotics vs F477

## 2026-05-31 06:39:39.493471 INFO::Creating boxplot for categorical data, antibiotics vs F312

## 2026-05-31 06:39:39.707293 INFO::Creating boxplot for categorical data, antibiotics vs F4

## 2026-05-31 06:39:39.906109 INFO::Creating boxplot for categorical data, antibiotics vs F632

## 2026-05-31 06:39:40.1206 INFO::Creating boxplot for categorical data, antibiotics vs F31

## 2026-05-31 06:39:40.318459 INFO::Creating boxplot for categorical data, antibiotics vs F184

## 2026-05-31 06:39:40.515295 INFO::Creating boxplot for categorical data, antibiotics vs F7

## 2026-05-31 06:39:40.731257 INFO::Creating boxplot for categorical data, antibiotics vs F213

## 2026-05-31 06:39:40.930626 INFO::Creating boxplot for categorical data, antibiotics vs F828

## 2026-05-31 06:39:41.152561 INFO::Creating boxplot for categorical data, antibiotics vs F831

## 2026-05-31 06:39:41.353486 INFO::Creating boxplot for categorical data, antibiotics vs F315

## 2026-05-31 06:39:41.567952 INFO::Creating boxplot for categorical data, antibiotics vs F691

## 2026-05-31 06:39:41.763839 INFO::Creating boxplot for categorical data, antibiotics vs F159

## 2026-05-31 06:39:41.966515 INFO::Creating boxplot for categorical data, antibiotics vs F331

## 2026-05-31 06:39:42.175213 INFO::Creating boxplot for categorical data, antibiotics vs F757

## 2026-05-31 06:39:42.372851 INFO::Creating boxplot for categorical data, antibiotics vs F167

## 2026-05-31 06:39:42.588503 INFO::Creating boxplot for categorical data, antibiotics vs F85

## 2026-05-31 06:39:42.786324 INFO::Creating boxplot for categorical data, antibiotics vs F80

## 2026-05-31 06:39:43.000085 INFO::Creating boxplot for categorical data, antibiotics vs F105

## 2026-05-31 06:39:43.198651 INFO::Creating boxplot for categorical data, antibiotics vs F674

## 2026-05-31 06:39:43.413166 INFO::Creating boxplot for categorical data, antibiotics vs F50

## 2026-05-31 06:39:43.610743 INFO::Creating boxplot for categorical data, antibiotics vs F164

## 2026-05-31 06:39:43.822623 INFO::Creating boxplot for categorical data, antibiotics vs F840

## 2026-05-31 06:39:44.022039 INFO::Creating boxplot for categorical data, antibiotics vs F232

## 2026-05-31 06:39:44.216705 INFO::Creating boxplot for categorical data, antibiotics vs F872

## 2026-05-31 06:39:44.435243 INFO::Creating boxplot for categorical data, antibiotics vs F54

## 2026-05-31 06:39:44.631593 INFO::Creating boxplot for categorical data, antibiotics vs F365

## 2026-05-31 06:39:44.848113 INFO::Creating boxplot for categorical data, antibiotics vs F499

## 2026-05-31 06:39:45.043738 INFO::Creating boxplot for categorical data, antibiotics vs F510

## 2026-05-31 06:39:45.258055 INFO::Creating boxplot for categorical data, antibiotics vs F716

## 2026-05-31 06:39:45.455443 INFO::Creating boxplot for categorical data, antibiotics vs F454

## 2026-05-31 06:39:45.725798 INFO::Creating boxplot for categorical data, antibiotics vs F52

## 2026-05-31 06:39:45.924901 INFO::Creating boxplot for categorical data, antibiotics vs F273

## 2026-05-31 06:39:46.138209 INFO::Creating boxplot for categorical data, antibiotics vs F474

## 2026-05-31 06:39:46.352213 INFO::Creating boxplot for categorical data, antibiotics vs F267

## 2026-05-31 06:39:46.551291 INFO::Creating boxplot for categorical data, antibiotics vs F253

## 2026-05-31 06:39:46.777577 INFO::Creating boxplot for categorical data, antibiotics vs F247

## 2026-05-31 06:39:46.977759 INFO::Creating boxplot for categorical data, antibiotics vs F708

## 2026-05-31 06:39:47.203569 INFO::Creating boxplot for categorical data, antibiotics vs F438

## 2026-05-31 06:39:47.402953 INFO::Creating boxplot for categorical data, antibiotics vs F450

## 2026-05-31 06:39:47.602613 INFO::Creating boxplot for categorical data, antibiotics vs F666

## 2026-05-31 06:39:47.83126 INFO::Creating boxplot for categorical data, antibiotics vs F720

## 2026-05-31 06:39:48.029719 INFO::Creating boxplot for categorical data, antibiotics vs F48

## 2026-05-31 06:39:48.258374 INFO::Creating boxplot for categorical data, antibiotics vs F371

## 2026-05-31 06:39:48.456927 INFO::Creating boxplot for categorical data, antibiotics vs F423

## 2026-05-31 06:39:48.677029 INFO::Creating boxplot for categorical data, antibiotics vs F351

## 2026-05-31 06:39:48.884197 INFO::Creating boxplot for categorical data, antibiotics vs F190

## 2026-05-31 06:39:49.082312 INFO::Creating boxplot for categorical data, antibiotics vs F394

## 2026-05-31 06:39:49.307976 INFO::Creating boxplot for categorical data, antibiotics vs F581

## 2026-05-31 06:39:49.507931 INFO::Creating boxplot for categorical data, antibiotics vs F276

## 2026-05-31 06:39:49.737702 INFO::Creating boxplot for categorical data, antibiotics vs F608

## 2026-05-31 06:39:49.937343 INFO::Creating boxplot for categorical data, antibiotics vs F28

## 2026-05-31 06:39:50.158775 INFO::Creating boxplot for categorical data, antibiotics vs F805

## 2026-05-31 06:39:50.364291 INFO::Creating boxplot for categorical data, antibiotics vs F776

## 2026-05-31 06:39:50.563865 INFO::Creating boxplot for categorical data, antibiotics vs F249

## 2026-05-31 06:39:50.790151 INFO::Creating boxplot for categorical data, antibiotics vs F755

## 2026-05-31 06:39:50.99112 INFO::Creating boxplot for categorical data, antibiotics vs F68

## 2026-05-31 06:39:51.220392 INFO::Creating boxplot for categorical data, antibiotics vs F78

## 2026-05-31 06:39:51.419272 INFO::Creating boxplot for categorical data, antibiotics vs F644

## 2026-05-31 06:39:51.648093 INFO::Creating boxplot for categorical data, antibiotics vs F381

## 2026-05-31 06:39:51.84653 INFO::Creating boxplot for categorical data, antibiotics vs F358

## 2026-05-31 06:39:52.059596 INFO::Creating boxplot for categorical data, antibiotics vs F344

## 2026-05-31 06:39:52.271801 INFO::Creating boxplot for categorical data, antibiotics vs F898

## 2026-05-31 06:39:52.471338 INFO::Creating boxplot for categorical data, antibiotics vs F209

## 2026-05-31 06:39:52.698245 INFO::Creating boxplot for categorical data, antibiotics vs F51

## 2026-05-31 06:39:52.89924 INFO::Creating boxplot for categorical data, antibiotics vs F149

## 2026-05-31 06:39:53.126027 INFO::Creating boxplot for categorical data, antibiotics vs F108

## 2026-05-31 06:39:53.325054 INFO::Creating boxplot for categorical data, antibiotics vs F255

## 2026-05-31 06:39:53.55251 INFO::Creating boxplot for categorical data, antibiotics vs F823

## 2026-05-31 06:39:53.751783 INFO::Creating boxplot for categorical data, antibiotics vs F864

## 2026-05-31 06:39:53.974162 INFO::Creating boxplot for categorical data, antibiotics vs F214

## 2026-05-31 06:39:54.180413 INFO::Creating boxplot for categorical data, antibiotics vs F76

## 2026-05-31 06:39:54.39157 INFO::Creating boxplot for categorical data, antibiotics vs F575

## 2026-05-31 06:39:54.607198 INFO::Creating boxplot for categorical data, antibiotics vs F13

## 2026-05-31 06:39:54.805106 INFO::Creating boxplot for categorical data, antibiotics vs F389

## 2026-05-31 06:39:55.031242 INFO::Creating boxplot for categorical data, antibiotics vs F556

## 2026-05-31 06:39:55.231962 INFO::Creating boxplot for categorical data, antibiotics vs F49

## 2026-05-31 06:39:55.456041 INFO::Creating boxplot for categorical data, antibiotics vs F436

## 2026-05-31 06:39:55.659156 INFO::Creating boxplot for categorical data, antibiotics vs F378

## 2026-05-31 06:39:55.953931 INFO::Creating boxplot for categorical data, antibiotics vs F682

## 2026-05-31 06:39:56.157488 INFO::Creating boxplot for categorical data, antibiotics vs F47

## 2026-05-31 06:39:56.383741 INFO::Creating boxplot for categorical data, antibiotics vs F429

## 2026-05-31 06:39:56.584835 INFO::Creating boxplot for categorical data, antibiotics vs F588

## 2026-05-31 06:39:56.785508 INFO::Creating boxplot for categorical data, antibiotics vs F616

## 2026-05-31 06:39:57.01171 INFO::Creating boxplot for categorical data, antibiotics vs F323

## 2026-05-31 06:39:57.212406 INFO::Creating boxplot for categorical data, antibiotics vs F409

## 2026-05-31 06:39:57.43677 INFO::Creating boxplot for categorical data, antibiotics vs F326

## 2026-05-31 06:39:57.638011 INFO::Creating boxplot for categorical data, antibiotics vs F567

## 2026-05-31 06:39:57.836627 INFO::Creating boxplot for categorical data, antibiotics vs F698

## 2026-05-31 06:39:58.062702 INFO::Creating boxplot for categorical data, antibiotics vs F179

## 2026-05-31 06:39:58.2651 INFO::Creating boxplot for categorical data, antibiotics vs F79

## 2026-05-31 06:39:58.488667 INFO::Creating boxplot for categorical data, antibiotics vs F787

## 2026-05-31 06:39:58.689841 INFO::Creating boxplot for categorical data, antibiotics vs F335

## 2026-05-31 06:39:58.917109 INFO::Creating boxplot for categorical data, antibiotics vs F576

## 2026-05-31 06:39:59.117188 INFO::Creating boxplot for categorical data, antibiotics vs F667

## 2026-05-31 06:39:59.317743 INFO::Creating boxplot for categorical data, antibiotics vs F694

## 2026-05-31 06:39:59.543287 INFO::Creating boxplot for categorical data, antibiotics vs F297

## 2026-05-31 06:39:59.743994 INFO::Creating boxplot for categorical data, antibiotics vs F569

## 2026-05-31 06:39:59.970564 INFO::Creating boxplot for categorical data, antibiotics vs F611

## 2026-05-31 06:40:00.172704 INFO::Creating boxplot for categorical data, antibiotics vs F810

## 2026-05-31 06:40:00.399988 INFO::Creating boxplot for categorical data, antibiotics vs F746

## 2026-05-31 06:40:00.602751 INFO::Creating boxplot for categorical data, antibiotics vs F23

## 2026-05-31 06:40:00.848301 INFO::Creating boxplot for categorical data, antibiotics vs F138

## 2026-05-31 06:40:01.059808 INFO::Creating boxplot for categorical data, antibiotics vs F135

## 2026-05-31 06:40:01.26332 INFO::Creating boxplot for categorical data, antibiotics vs F411

## 2026-05-31 06:40:01.488052 INFO::Creating boxplot for categorical data, antibiotics vs F489

## 2026-05-31 06:40:01.691449 INFO::Creating boxplot for categorical data, antibiotics vs F492

## 2026-05-31 06:40:01.917216 INFO::Creating boxplot for categorical data, antibiotics vs F844

## 2026-05-31 06:40:02.119116 INFO::Creating boxplot for categorical data, antibiotics vs F586

## 2026-05-31 06:40:02.344836 INFO::Creating boxplot for categorical data, antibiotics vs F11

## 2026-05-31 06:40:02.547779 INFO::Creating boxplot for categorical data, antibiotics vs F900

## 2026-05-31 06:40:02.761712 INFO::Creating boxplot for categorical data, antibiotics vs F21

## 2026-05-31 06:40:02.975711 INFO::Creating boxplot for categorical data, antibiotics vs F736

## 2026-05-31 06:40:03.180866 INFO::Creating boxplot for categorical data, antibiotics vs F66

## 2026-05-31 06:40:03.405226 INFO::Creating boxplot for categorical data, antibiotics vs F408

## 2026-05-31 06:40:03.606794 INFO::Creating boxplot for categorical data, antibiotics vs F788

## 2026-05-31 06:40:03.831132 INFO::Creating boxplot for categorical data, antibiotics vs F493

## 2026-05-31 06:40:04.032344 INFO::Creating boxplot for categorical data, antibiotics vs F343

## 2026-05-31 06:40:04.256279 INFO::Creating boxplot for categorical data, antibiotics vs F352

## 2026-05-31 06:40:04.457586 INFO::Creating boxplot for categorical data, antibiotics vs F677

## 2026-05-31 06:40:04.681031 INFO::Creating boxplot for categorical data, antibiotics vs F816

## 2026-05-31 06:40:04.881983 INFO::Creating boxplot for categorical data, antibiotics vs F457

## 2026-05-31 06:40:05.100205 INFO::Creating boxplot for categorical data, antibiotics vs F330

## 2026-05-31 06:40:05.306468 INFO::Creating boxplot for categorical data, antibiotics vs F293

## 2026-05-31 06:40:05.504486 INFO::Creating boxplot for categorical data, antibiotics vs F725

## 2026-05-31 06:40:05.729169 INFO::Creating boxplot for categorical data, antibiotics vs F813

## 2026-05-31 06:40:05.930019 INFO::Creating boxplot for categorical data, antibiotics vs F295

## 2026-05-31 06:40:06.783813 INFO::Creating boxplot for categorical data, antibiotics vs F656

## 2026-05-31 06:40:06.964448 INFO::Creating boxplot for categorical data, antibiotics vs F669

## 2026-05-31 06:40:07.152802 INFO::Creating boxplot for categorical data, antibiotics vs F15

## 2026-05-31 06:40:07.331201 INFO::Creating boxplot for categorical data, antibiotics vs F419

## 2026-05-31 06:40:07.51275 INFO::Creating boxplot for categorical data, antibiotics vs F701

## 2026-05-31 06:40:07.699849 INFO::Creating boxplot for categorical data, antibiotics vs F176

## 2026-05-31 06:40:07.882659 INFO::Creating boxplot for categorical data, antibiotics vs F203

## 2026-05-31 06:40:08.071554 INFO::Creating boxplot for categorical data, antibiotics vs F501

## 2026-05-31 06:40:08.251853 INFO::Creating boxplot for categorical data, antibiotics vs F772

## 2026-05-31 06:40:08.433368 INFO::Creating boxplot for categorical data, antibiotics vs F488

## 2026-05-31 06:40:08.619621 INFO::Creating boxplot for categorical data, antibiotics vs F600

## 2026-05-31 06:40:08.799603 INFO::Creating boxplot for categorical data, antibiotics vs F768

## 2026-05-31 06:40:08.989099 INFO::Creating boxplot for categorical data, antibiotics vs F432

## 2026-05-31 06:40:09.16951 INFO::Creating boxplot for categorical data, antibiotics vs F26

## 2026-05-31 06:40:09.351336 INFO::Creating boxplot for categorical data, antibiotics vs F189

## 2026-05-31 06:40:09.536707 INFO::Creating boxplot for categorical data, antibiotics vs F200

## 2026-05-31 06:40:09.717044 INFO::Creating boxplot for categorical data, antibiotics vs F121

## 2026-05-31 06:40:09.906463 INFO::Creating boxplot for categorical data, antibiotics vs F624

## 2026-05-31 06:40:10.087352 INFO::Creating boxplot for categorical data, antibiotics vs F855

## 2026-05-31 06:40:10.270908 INFO::Creating boxplot for categorical data, antibiotics vs F380

## 2026-05-31 06:40:10.457439 INFO::Creating boxplot for categorical data, antibiotics vs F734

## 2026-05-31 06:40:10.63851 INFO::Creating boxplot for categorical data, antibiotics vs F16

## 2026-05-31 06:40:10.827322 INFO::Creating boxplot for categorical data, antibiotics vs F602

## 2026-05-31 06:40:11.008305 INFO::Creating boxplot for categorical data, antibiotics vs F210

## 2026-05-31 06:40:11.197513 INFO::Creating boxplot for categorical data, antibiotics vs F217

## 2026-05-31 06:40:11.379198 INFO::Creating boxplot for categorical data, antibiotics vs F640

## 2026-05-31 06:40:11.560196 INFO::Creating boxplot for categorical data, antibiotics vs F631

## 2026-05-31 06:40:11.750267 INFO::Creating boxplot for categorical data, antibiotics vs F32

## 2026-05-31 06:40:11.934828 INFO::Creating boxplot for categorical data, antibiotics vs F322

## 2026-05-31 06:40:12.124389 INFO::Creating boxplot for categorical data, antibiotics vs F476

## 2026-05-31 06:40:12.30512 INFO::Creating boxplot for categorical data, antibiotics vs F265

## 2026-05-31 06:40:12.488721 INFO::Creating boxplot for categorical data, antibiotics vs F283

## 2026-05-31 06:40:12.675912 INFO::Creating boxplot for categorical data, antibiotics vs F316

## 2026-05-31 06:40:12.860016 INFO::Creating boxplot for categorical data, antibiotics vs F465

## 2026-05-31 06:40:13.048278 INFO::Creating boxplot for categorical data, antibiotics vs F24

## 2026-05-31 06:40:13.229515 INFO::Creating boxplot for categorical data, antibiotics vs F38

## 2026-05-31 06:40:13.420548 INFO::Creating boxplot for categorical data, antibiotics vs F82

## 2026-05-31 06:40:13.599547 INFO::Creating boxplot for categorical data, antibiotics vs F86

## 2026-05-31 06:40:13.787236 INFO::Creating boxplot for categorical data, antibiotics vs F270

## 2026-05-31 06:40:13.977135 INFO::Creating boxplot for categorical data, antibiotics vs F485

## 2026-05-31 06:40:14.158475 INFO::Creating boxplot for categorical data, antibiotics vs F877

## 2026-05-31 06:40:14.347293 INFO::Creating boxplot for categorical data, antibiotics vs F486

## 2026-05-31 06:40:14.529191 INFO::Creating boxplot for categorical data, antibiotics vs F399

## 2026-05-31 06:40:14.718736 INFO::Creating boxplot for categorical data, antibiotics vs F573

## 2026-05-31 06:40:14.900254 INFO::Creating boxplot for categorical data, antibiotics vs F709

## 2026-05-31 06:40:15.083888 INFO::Creating boxplot for categorical data, antibiotics vs F227

## 2026-05-31 06:40:15.271916 INFO::Creating boxplot for categorical data, antibiotics vs F553

## 2026-05-31 06:40:15.453647 INFO::Creating boxplot for categorical data, antibiotics vs F123

## 2026-05-31 06:40:15.641244 INFO::Creating boxplot for categorical data, antibiotics vs F118

## 2026-05-31 06:40:15.823967 INFO::Creating boxplot for categorical data, antibiotics vs F605

## 2026-05-31 06:40:16.08517 INFO::Creating boxplot for categorical data, antibiotics vs F619

## 2026-05-31 06:40:16.277262 INFO::Creating boxplot for categorical data, antibiotics vs F830

## 2026-05-31 06:40:16.468877 INFO::Creating boxplot for categorical data, antibiotics vs F837

## 2026-05-31 06:40:16.676075 INFO::Creating boxplot for categorical data, antibiotics vs F12

## 2026-05-31 06:40:16.865278 INFO::Creating boxplot for categorical data, antibiotics vs F623

## 2026-05-31 06:40:17.068167 INFO::Creating boxplot for categorical data, antibiotics vs F806

## 2026-05-31 06:40:17.257776 INFO::Creating boxplot for categorical data, antibiotics vs F829

## 2026-05-31 06:40:17.443598 INFO::Creating boxplot for categorical data, antibiotics vs F289

## 2026-05-31 06:40:17.64899 INFO::Creating boxplot for categorical data, antibiotics vs F353

## 2026-05-31 06:40:17.838616 INFO::Creating boxplot for categorical data, antibiotics vs F93

## 2026-05-31 06:40:18.041214 INFO::Creating boxplot for categorical data, antibiotics vs F379

## 2026-05-31 06:40:18.23169 INFO::Creating boxplot for categorical data, antibiotics vs F370

## 2026-05-31 06:40:18.417911 INFO::Creating boxplot for categorical data, antibiotics vs F360

## 2026-05-31 06:40:18.624311 INFO::Creating boxplot for categorical data, antibiotics vs F710

## 2026-05-31 06:40:18.813232 INFO::Creating boxplot for categorical data, antibiotics vs F796

## 2026-05-31 06:40:19.017898 INFO::Creating boxplot for categorical data, antibiotics vs F388

## 2026-05-31 06:40:19.208537 INFO::Creating boxplot for categorical data, antibiotics vs F775

## 2026-05-31 06:40:19.395583 INFO::Creating boxplot for categorical data, antibiotics vs F174

## 2026-05-31 06:40:19.602215 INFO::Creating boxplot for categorical data, antibiotics vs F601

## 2026-05-31 06:40:19.790238 INFO::Creating boxplot for categorical data, antibiotics vs F836

## 2026-05-31 06:40:19.995969 INFO::Creating boxplot for categorical data, antibiotics vs F192

## 2026-05-31 06:40:20.18567 INFO::Creating boxplot for categorical data, antibiotics vs F463

## 2026-05-31 06:40:20.386462 INFO::Creating boxplot for categorical data, antibiotics vs F57

## 2026-05-31 06:40:20.58042 INFO::Creating boxplot for categorical data, antibiotics vs F658

## 2026-05-31 06:40:20.767359 INFO::Creating boxplot for categorical data, antibiotics vs F596

## 2026-05-31 06:40:20.970772 INFO::Creating boxplot for categorical data, antibiotics vs F104

## 2026-05-31 06:40:21.170671 INFO::Creating boxplot for categorical data, antibiotics vs F218

## 2026-05-31 06:40:21.39421 INFO::Creating boxplot for categorical data, antibiotics vs F466

## 2026-05-31 06:40:21.585886 INFO::Creating boxplot for categorical data, antibiotics vs F737

## 2026-05-31 06:40:21.772569 INFO::Creating boxplot for categorical data, antibiotics vs F487

## 2026-05-31 06:40:21.981055 INFO::Creating boxplot for categorical data, antibiotics vs F369

## 2026-05-31 06:40:22.17135 INFO::Creating boxplot for categorical data, antibiotics vs F584

## 2026-05-31 06:40:22.375561 INFO::Creating boxplot for categorical data, antibiotics vs F166

## 2026-05-31 06:40:22.566904 INFO::Creating boxplot for categorical data, antibiotics vs F822

## 2026-05-31 06:40:22.771932 INFO::Creating boxplot for categorical data, antibiotics vs F70

## 2026-05-31 06:40:22.965539 INFO::Creating boxplot for categorical data, antibiotics vs F243

## 2026-05-31 06:40:23.155374 INFO::Creating boxplot for categorical data, antibiotics vs F498

## 2026-05-31 06:40:23.36301 INFO::Creating boxplot for categorical data, antibiotics vs F272

## 2026-05-31 06:40:23.551975 INFO::Creating boxplot for categorical data, antibiotics vs F881

## 2026-05-31 06:40:23.756016 INFO::Creating boxplot for categorical data, antibiotics vs F761

## 2026-05-31 06:40:23.945004 INFO::Creating boxplot for categorical data, antibiotics vs F781

## 2026-05-31 06:40:24.148224 INFO::Creating boxplot for categorical data, antibiotics vs F697

## 2026-05-31 06:40:24.339685 INFO::Creating boxplot for categorical data, antibiotics vs F890

## 2026-05-31 06:40:24.530926 INFO::Creating boxplot for categorical data, antibiotics vs F197

## 2026-05-31 06:40:24.742982 INFO::Creating boxplot for categorical data, antibiotics vs F826

## 2026-05-31 06:40:24.934861 INFO::Creating boxplot for categorical data, antibiotics vs F641

## 2026-05-31 06:40:25.144601 INFO::Creating boxplot for categorical data, antibiotics vs F700

## 2026-05-31 06:40:25.334768 INFO::Creating boxplot for categorical data, antibiotics vs F280

## 2026-05-31 06:40:25.540101 INFO::Creating boxplot for categorical data, antibiotics vs F531

## 2026-05-31 06:40:25.729391 INFO::Creating boxplot for categorical data, antibiotics vs F660

## 2026-05-31 06:40:25.978633 INFO::Creating boxplot for categorical data, antibiotics vs F257

## 2026-05-31 06:40:26.1785 INFO::Creating boxplot for categorical data, antibiotics vs F136

## 2026-05-31 06:40:26.373915 INFO::Creating boxplot for categorical data, antibiotics vs F875

## 2026-05-31 06:40:26.592097 INFO::Creating boxplot for categorical data, antibiotics vs F160

## 2026-05-31 06:40:26.787189 INFO::Creating boxplot for categorical data, antibiotics vs F642

## 2026-05-31 06:40:26.994221 INFO::Creating boxplot for categorical data, antibiotics vs F782

## 2026-05-31 06:40:27.209615 INFO::Creating boxplot for categorical data, antibiotics vs F730

## 2026-05-31 06:40:27.404613 INFO::Creating boxplot for categorical data, antibiotics vs F679

## 2026-05-31 06:40:27.621972 INFO::Creating boxplot for categorical data, antibiotics vs F713

## 2026-05-31 06:40:27.815272 INFO::Creating boxplot for categorical data, antibiotics vs F821

## 2026-05-31 06:40:28.023109 INFO::Creating boxplot for categorical data, antibiotics vs F443

## 2026-05-31 06:40:28.230097 INFO::Creating boxplot for categorical data, antibiotics vs F25

## 2026-05-31 06:40:28.426696 INFO::Creating boxplot for categorical data, antibiotics vs F338

## 2026-05-31 06:40:28.644338 INFO::Creating boxplot for categorical data, antibiotics vs F647

## 2026-05-31 06:40:28.839556 INFO::Creating boxplot for categorical data, antibiotics vs F729

## 2026-05-31 06:40:29.058771 INFO::Creating boxplot for categorical data, antibiotics vs F817

## 2026-05-31 06:40:29.260081 INFO::Creating boxplot for categorical data, antibiotics vs F535

## 2026-05-31 06:40:29.456394 INFO::Creating boxplot for categorical data, antibiotics vs F634

## 2026-05-31 06:40:29.679885 INFO::Creating boxplot for categorical data, antibiotics vs F533

## 2026-05-31 06:40:29.876738 INFO::Creating boxplot for categorical data, antibiotics vs F571

## 2026-05-31 06:40:30.094377 INFO::Creating boxplot for categorical data, antibiotics vs F808

## 2026-05-31 06:40:30.289999 INFO::Creating boxplot for categorical data, antibiotics vs F529

## 2026-05-31 06:40:30.485835 INFO::Creating boxplot for categorical data, antibiotics vs F827

## 2026-05-31 06:40:30.703595 INFO::Creating boxplot for categorical data, antibiotics vs F107

## 2026-05-31 06:40:30.901122 INFO::Creating boxplot for categorical data, antibiotics vs F515

## 2026-05-31 06:40:31.15058 INFO::Creating boxplot for categorical data, antibiotics vs F305

## 2026-05-31 06:40:31.347208 INFO::Creating boxplot for categorical data, antibiotics vs F662

## 2026-05-31 06:40:31.555224 INFO::Creating boxplot for categorical data, antibiotics vs F310

## 2026-05-31 06:40:31.764898 INFO::Creating boxplot for categorical data, antibiotics vs F173

## 2026-05-31 06:40:31.961185 INFO::Creating boxplot for categorical data, antibiotics vs F820

## 2026-05-31 06:40:32.185108 INFO::Creating boxplot for categorical data, antibiotics vs F743

## 2026-05-31 06:40:32.384722 INFO::Creating boxplot for categorical data, antibiotics vs F63

## 2026-05-31 06:40:32.607082 INFO::Creating boxplot for categorical data, antibiotics vs F215

## 2026-05-31 06:40:32.801429 INFO::Creating boxplot for categorical data, antibiotics vs F216

## 2026-05-31 06:40:32.995968 INFO::Creating boxplot for categorical data, antibiotics vs F245

## 2026-05-31 06:40:33.217343 INFO::Creating boxplot for categorical data, antibiotics vs F430

## 2026-05-31 06:40:33.413742 INFO::Creating boxplot for categorical data, antibiotics vs F862

## 2026-05-31 06:40:33.633507 INFO::Creating boxplot for categorical data, antibiotics vs F541

## 2026-05-31 06:40:33.834817 INFO::Creating boxplot for categorical data, antibiotics vs F558

## 2026-05-31 06:40:34.058399 INFO::Creating boxplot for categorical data, antibiotics vs F633

## 2026-05-31 06:40:34.254867 INFO::Creating boxplot for categorical data, antibiotics vs F94

## 2026-05-31 06:40:34.462444 INFO::Creating boxplot for categorical data, antibiotics vs F238

## 2026-05-31 06:40:34.671045 INFO::Creating boxplot for categorical data, antibiotics vs F574

## 2026-05-31 06:40:34.863645 INFO::Creating boxplot for categorical data, antibiotics vs F815

## 2026-05-31 06:40:35.081416 INFO::Creating boxplot for categorical data, antibiotics vs F587

## 2026-05-31 06:40:35.275115 INFO::Creating boxplot for categorical data, antibiotics vs F464

## 2026-05-31 06:40:35.491833 INFO::Creating boxplot for categorical data, antibiotics vs F590

## 2026-05-31 06:40:35.687388 INFO::Creating boxplot for categorical data, antibiotics vs F124

## 2026-05-31 06:40:35.905809 INFO::Creating boxplot for categorical data, antibiotics vs F664

## 2026-05-31 06:40:36.098642 INFO::Creating boxplot for categorical data, antibiotics vs F100

## 2026-05-31 06:40:36.374939 INFO::Creating boxplot for categorical data, antibiotics vs F444

## 2026-05-31 06:40:36.582165 INFO::Creating boxplot for categorical data, antibiotics vs F147

## 2026-05-31 06:40:36.78138 INFO::Creating boxplot for categorical data, antibiotics vs F597

## 2026-05-31 06:40:37.00258 INFO::Creating boxplot for categorical data, antibiotics vs F650

## 2026-05-31 06:40:37.197752 INFO::Creating boxplot for categorical data, antibiotics vs F363

## 2026-05-31 06:40:37.393442 INFO::Creating boxplot for categorical data, antibiotics vs F521

## 2026-05-31 06:40:37.609829 INFO::Creating boxplot for categorical data, antibiotics vs F412

## 2026-05-31 06:40:37.807531 INFO::Creating boxplot for categorical data, antibiotics vs F279

## 2026-05-31 06:40:38.028949 INFO::Creating boxplot for categorical data, antibiotics vs F225

## 2026-05-31 06:40:38.230369 INFO::Creating boxplot for categorical data, antibiotics vs F10

## 2026-05-31 06:40:38.430151 INFO::Creating boxplot for categorical data, antibiotics vs F481

## 2026-05-31 06:40:38.650594 INFO::Creating boxplot for categorical data, antibiotics vs F861

## 2026-05-31 06:40:38.850425 INFO::Creating boxplot for categorical data, antibiotics vs F888

## 2026-05-31 06:40:39.072021 INFO::Creating boxplot for categorical data, antibiotics vs F156

## 2026-05-31 06:40:39.270179 INFO::Creating boxplot for categorical data, antibiotics vs F857

## 2026-05-31 06:40:39.470173 INFO::Creating boxplot for categorical data, antibiotics vs F294

## 2026-05-31 06:40:39.693166 INFO::Creating boxplot for categorical data, antibiotics vs F244

## 2026-05-31 06:40:39.894854 INFO::Creating boxplot for categorical data, antibiotics vs F514

## 2026-05-31 06:40:40.118939 INFO::Creating boxplot for categorical data, antibiotics vs F304

## 2026-05-31 06:40:40.324564 INFO::Creating boxplot for categorical data, antibiotics vs F509

## 2026-05-31 06:40:40.539848 INFO::Creating boxplot for categorical data, antibiotics vs F196

## 2026-05-31 06:40:40.750964 INFO::Creating boxplot for categorical data, antibiotics vs F550

## 2026-05-31 06:40:40.952611 INFO::Creating boxplot for categorical data, antibiotics vs F833

## 2026-05-31 06:40:41.174791 INFO::Creating boxplot for categorical data, antibiotics vs F869

## 2026-05-31 06:40:41.375872 INFO::Creating boxplot for categorical data, antibiotics vs F364

## 2026-05-31 06:40:41.597492 INFO::Creating boxplot for categorical data, antibiotics vs F583

## 2026-05-31 06:40:41.795105 INFO::Creating boxplot for categorical data, antibiotics vs F441

## 2026-05-31 06:40:41.995286 INFO::Creating boxplot for categorical data, antibiotics vs F595

## 2026-05-31 06:40:42.215714 INFO::Creating boxplot for categorical data, antibiotics vs F35

## 2026-05-31 06:40:42.416237 INFO::Creating boxplot for categorical data, antibiotics vs F630

## 2026-05-31 06:40:42.637472 INFO::Creating boxplot for categorical data, antibiotics vs F401

## 2026-05-31 06:40:42.835163 INFO::Creating boxplot for categorical data, antibiotics vs F239

## 2026-05-31 06:40:43.044922 INFO::Creating boxplot for categorical data, antibiotics vs F250

## 2026-05-31 06:40:43.249961 INFO::Creating boxplot for categorical data, antibiotics vs F287

## 2026-05-31 06:40:43.449501 INFO::Creating boxplot for categorical data, antibiotics vs F88

## 2026-05-31 06:40:43.665727 INFO::Creating boxplot for categorical data, antibiotics vs F539

## 2026-05-31 06:40:43.86449 INFO::Creating boxplot for categorical data, antibiotics vs F752

## 2026-05-31 06:40:44.082559 INFO::Creating boxplot for categorical data, antibiotics vs F126

## 2026-05-31 06:40:44.280273 INFO::Creating boxplot for categorical data, antibiotics vs F362

## 2026-05-31 06:40:44.487823 INFO::Creating boxplot for categorical data, antibiotics vs F69

## 2026-05-31 06:40:44.694348 INFO::Creating boxplot for categorical data, antibiotics vs F753

## 2026-05-31 06:40:44.89362 INFO::Creating boxplot for categorical data, antibiotics vs F469

## 2026-05-31 06:40:45.110215 INFO::Creating boxplot for categorical data, antibiotics vs F14

## 2026-05-31 06:40:45.308503 INFO::Creating boxplot for categorical data, antibiotics vs F803

## 2026-05-31 06:40:45.526196 INFO::Creating boxplot for categorical data, antibiotics vs F814

## 2026-05-31 06:40:45.72314 INFO::Creating boxplot for categorical data, antibiotics vs F449

## 2026-05-31 06:40:45.940739 INFO::Creating boxplot for categorical data, antibiotics vs F494

## 2026-05-31 06:40:46.138726 INFO::Creating boxplot for categorical data, antibiotics vs F439

## 2026-05-31 06:40:46.334306 INFO::Creating boxplot for categorical data, antibiotics vs F686

## 2026-05-31 06:40:46.551203 INFO::Creating boxplot for categorical data, antibiotics vs F591

## 2026-05-31 06:40:46.749452 INFO::Creating boxplot for categorical data, antibiotics vs F735

## 2026-05-31 06:40:47.024026 INFO::Creating boxplot for categorical data, antibiotics vs F111

## 2026-05-31 06:40:47.223671 INFO::Creating boxplot for categorical data, antibiotics vs F346

## 2026-05-31 06:40:47.436967 INFO::Creating boxplot for categorical data, antibiotics vs F29

## 2026-05-31 06:40:47.653231 INFO::Creating boxplot for categorical data, antibiotics vs F376

## 2026-05-31 06:40:47.853297 INFO::Creating boxplot for categorical data, antibiotics vs F414

## 2026-05-31 06:40:48.08376 INFO::Creating boxplot for categorical data, antibiotics vs F555

## 2026-05-31 06:40:48.282615 INFO::Creating boxplot for categorical data, antibiotics vs F517

## 2026-05-31 06:40:48.496251 INFO::Creating boxplot for categorical data, antibiotics vs F544

## 2026-05-31 06:40:48.715457 INFO::Creating boxplot for categorical data, antibiotics vs F339

## 2026-05-31 06:40:48.917332 INFO::Creating boxplot for categorical data, antibiotics vs F689

## 2026-05-31 06:40:49.148708 INFO::Creating boxplot for categorical data, antibiotics vs F391

## 2026-05-31 06:40:49.346838 INFO::Creating boxplot for categorical data, antibiotics vs F502

## 2026-05-31 06:40:49.56418 INFO::Creating boxplot for categorical data, antibiotics vs F298

## 2026-05-31 06:40:49.778646 INFO::Creating boxplot for categorical data, antibiotics vs F337

## 2026-05-31 06:40:49.979882 INFO::Creating boxplot for categorical data, antibiotics vs F773

## 2026-05-31 06:40:50.209955 INFO::Creating boxplot for categorical data, antibiotics vs F592

## 2026-05-31 06:40:50.410108 INFO::Creating boxplot for categorical data, antibiotics vs F307

## 2026-05-31 06:40:50.63735 INFO::Creating boxplot for categorical data, antibiotics vs F115

## 2026-05-31 06:40:50.839959 INFO::Creating boxplot for categorical data, antibiotics vs F739

## 2026-05-31 06:40:51.040874 INFO::Creating boxplot for categorical data, antibiotics vs F433

## 2026-05-31 06:40:51.272562 INFO::Creating boxplot for categorical data, antibiotics vs F384

## 2026-05-31 06:40:51.474393 INFO::Creating boxplot for categorical data, antibiotics vs F750

## 2026-05-31 06:40:51.707185 INFO::Creating boxplot for categorical data, antibiotics vs F762

## 2026-05-31 06:40:51.906637 INFO::Creating boxplot for categorical data, antibiotics vs F277

## 2026-05-31 06:40:52.117739 INFO::Creating boxplot for categorical data, antibiotics vs F839

## 2026-05-31 06:40:52.339425 INFO::Creating boxplot for categorical data, antibiotics vs F127

## 2026-05-31 06:40:52.539699 INFO::Creating boxplot for categorical data, antibiotics vs F554

## 2026-05-31 06:40:52.768773 INFO::Creating boxplot for categorical data, antibiotics vs F676

## 2026-05-31 06:40:52.96809 INFO::Creating boxplot for categorical data, antibiotics vs F568

## 2026-05-31 06:40:53.195388 INFO::Creating boxplot for categorical data, antibiotics vs F137

## 2026-05-31 06:40:53.39613 INFO::Creating boxplot for categorical data, antibiotics vs F871

## 2026-05-31 06:40:53.595813 INFO::Creating boxplot for categorical data, antibiotics vs F60

## 2026-05-31 06:40:53.823627 INFO::Creating boxplot for categorical data, antibiotics vs F98

## 2026-05-31 06:40:54.024653 INFO::Creating boxplot for categorical data, antibiotics vs F131

## 2026-05-31 06:40:54.256053 INFO::Creating boxplot for categorical data, antibiotics vs F530

## 2026-05-31 06:40:54.453294 INFO::Creating boxplot for categorical data, antibiotics vs F809

## 2026-05-31 06:40:54.680268 INFO::Creating boxplot for categorical data, antibiotics vs F894

## 2026-05-31 06:40:54.886505 INFO::Creating boxplot for categorical data, antibiotics vs F22

## 2026-05-31 06:40:55.089251 INFO::Creating boxplot for categorical data, antibiotics vs F818

## 2026-05-31 06:40:55.320241 INFO::Creating boxplot for categorical data, antibiotics vs F559

## 2026-05-31 06:40:55.52282 INFO::Creating boxplot for categorical data, antibiotics vs F741

## 2026-05-31 06:40:55.759872 INFO::Creating boxplot for categorical data, antibiotics vs F398

## 2026-05-31 06:40:55.965242 INFO::Creating boxplot for categorical data, antibiotics vs F357

## 2026-05-31 06:40:56.19872 INFO::Creating boxplot for categorical data, antibiotics vs F426

## 2026-05-31 06:40:56.399931 INFO::Creating boxplot for categorical data, antibiotics vs F119

## 2026-05-31 06:40:56.61731 INFO::Creating boxplot for categorical data, antibiotics vs F204

## 2026-05-31 06:40:56.834945 INFO::Creating boxplot for categorical data, antibiotics vs F851

## 2026-05-31 06:40:57.035901 INFO::Creating boxplot for categorical data, antibiotics vs F657

## 2026-05-31 06:40:57.268045 INFO::Creating boxplot for categorical data, antibiotics vs F801

## 2026-05-31 06:40:57.472814 INFO::Creating boxplot for categorical data, antibiotics vs F859

## 2026-05-31 06:40:57.782394 INFO::Creating boxplot for categorical data, antibiotics vs F480

## 2026-05-31 06:40:57.989955 INFO::Creating boxplot for categorical data, antibiotics vs F507

## 2026-05-31 06:40:58.214684 INFO::Creating boxplot for categorical data, antibiotics vs F207

## 2026-05-31 06:40:58.431804 INFO::Creating boxplot for categorical data, antibiotics vs F367

## 2026-05-31 06:41:00.532435 INFO::Plotting data for metadata number 3, age
## 2026-05-31 06:41:00.533848 INFO::Creating scatter plot for continuous data, age vs F340

## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.
## ℹ The deprecated feature was likely used in the Maaslin2 package.
##   Please report the issue at <https://github.com/biobakery/maaslin2/issues>.
## This warning is displayed once per session.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:00.845736 INFO::Creating scatter plot for continuous data, age vs F603

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:01.11305 INFO::Creating scatter plot for continuous data, age vs F356

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:01.34718 INFO::Creating scatter plot for continuous data, age vs F181

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:01.547478 INFO::Creating scatter plot for continuous data, age vs F177

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:01.747259 INFO::Creating scatter plot for continuous data, age vs F390

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:01.979459 INFO::Creating scatter plot for continuous data, age vs F743

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:02.17981 INFO::Creating scatter plot for continuous data, age vs F491

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:02.409535 INFO::Creating scatter plot for continuous data, age vs F436

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:02.596943 INFO::Creating scatter plot for continuous data, age vs F219

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:02.794471 INFO::Creating scatter plot for continuous data, age vs F483

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:03.022432 INFO::Creating scatter plot for continuous data, age vs F878

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:03.223815 INFO::Creating scatter plot for continuous data, age vs F876

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:03.449158 INFO::Creating scatter plot for continuous data, age vs F211

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:03.64576 INFO::Creating scatter plot for continuous data, age vs F732

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:03.855338 INFO::Creating scatter plot for continuous data, age vs F222

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:04.045933 INFO::Creating scatter plot for continuous data, age vs F688

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:04.242301 INFO::Creating scatter plot for continuous data, age vs F170

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:04.466595 INFO::Creating scatter plot for continuous data, age vs F431

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:04.664152 INFO::Creating scatter plot for continuous data, age vs F174

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:04.878036 INFO::Creating scatter plot for continuous data, age vs F17

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:05.074513 INFO::Creating scatter plot for continuous data, age vs F334

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:05.290745 INFO::Creating scatter plot for continuous data, age vs F835

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:05.481213 INFO::Creating scatter plot for continuous data, age vs F223

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:05.678274 INFO::Creating scatter plot for continuous data, age vs F383

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:05.899095 INFO::Creating scatter plot for continuous data, age vs F623

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:06.085947 INFO::Creating scatter plot for continuous data, age vs F329

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:06.307754 INFO::Creating scatter plot for continuous data, age vs F395

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:06.503444 INFO::Creating scatter plot for continuous data, age vs F528

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:06.723365 INFO::Creating scatter plot for continuous data, age vs F13

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:06.90783 INFO::Creating scatter plot for continuous data, age vs F36

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:07.091158 INFO::Creating scatter plot for continuous data, age vs F285

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:07.312039 INFO::Creating scatter plot for continuous data, age vs F404

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:07.496927 INFO::Creating scatter plot for continuous data, age vs F894

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:07.715233 INFO::Creating scatter plot for continuous data, age vs F300

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:07.912349 INFO::Creating scatter plot for continuous data, age vs F32

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:08.121172 INFO::Creating scatter plot for continuous data, age vs F24

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:08.315446 INFO::Creating scatter plot for continuous data, age vs F97

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:09.219815 INFO::Creating scatter plot for continuous data, age vs F849

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:09.397806 INFO::Creating scatter plot for continuous data, age vs F185

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:09.573141 INFO::Creating scatter plot for continuous data, age vs F513

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:09.747306 INFO::Creating scatter plot for continuous data, age vs F296

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:09.923987 INFO::Creating scatter plot for continuous data, age vs F793

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:10.091615 INFO::Creating scatter plot for continuous data, age vs F471

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:10.274907 INFO::Creating scatter plot for continuous data, age vs F402

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:10.450131 INFO::Creating scatter plot for continuous data, age vs F541

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:10.633088 INFO::Creating scatter plot for continuous data, age vs F496

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:10.798488 INFO::Creating scatter plot for continuous data, age vs F386

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:10.974921 INFO::Creating scatter plot for continuous data, age vs F594

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:11.156558 INFO::Creating scatter plot for continuous data, age vs F704

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:11.333736 INFO::Creating scatter plot for continuous data, age vs F330

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:11.517281 INFO::Creating scatter plot for continuous data, age vs F197

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:11.691474 INFO::Creating scatter plot for continuous data, age vs F735

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:11.859888 INFO::Creating scatter plot for continuous data, age vs F481

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:12.033764 INFO::Creating scatter plot for continuous data, age vs F635

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:12.199542 INFO::Creating scatter plot for continuous data, age vs F687

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:12.385711 INFO::Creating scatter plot for continuous data, age vs F652

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:12.561158 INFO::Creating scatter plot for continuous data, age vs F651

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:12.738569 INFO::Creating scatter plot for continuous data, age vs F82

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:12.921779 INFO::Creating scatter plot for continuous data, age vs F7

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:13.088526 INFO::Creating scatter plot for continuous data, age vs F866

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:13.272678 INFO::Creating scatter plot for continuous data, age vs F593

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:13.450598 INFO::Creating scatter plot for continuous data, age vs F733

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:13.618894 INFO::Creating scatter plot for continuous data, age vs F410

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:13.803142 INFO::Creating scatter plot for continuous data, age vs F684

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:13.983668 INFO::Creating scatter plot for continuous data, age vs F224

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:14.167265 INFO::Creating scatter plot for continuous data, age vs F722

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:14.341446 INFO::Creating scatter plot for continuous data, age vs F856

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:14.52719 INFO::Creating scatter plot for continuous data, age vs F680

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:14.702184 INFO::Creating scatter plot for continuous data, age vs F19

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:14.869131 INFO::Creating scatter plot for continuous data, age vs F860

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:15.044025 INFO::Creating scatter plot for continuous data, age vs F859

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:15.210595 INFO::Creating scatter plot for continuous data, age vs F522

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:15.396187 INFO::Creating scatter plot for continuous data, age vs F372

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:15.570711 INFO::Creating scatter plot for continuous data, age vs F899

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:15.738971 INFO::Creating scatter plot for continuous data, age vs F782

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:15.914351 INFO::Creating scatter plot for continuous data, age vs F839

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:16.081036 INFO::Creating scatter plot for continuous data, age vs F827

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:16.257687 INFO::Creating scatter plot for continuous data, age vs F817

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:16.433825 INFO::Creating scatter plot for continuous data, age vs F345

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:16.612341 INFO::Creating scatter plot for continuous data, age vs F127

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:16.796288 INFO::Creating scatter plot for continuous data, age vs F749

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:16.974247 INFO::Creating scatter plot for continuous data, age vs F150

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:17.15815 INFO::Creating scatter plot for continuous data, age vs F752

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:17.325259 INFO::Creating scatter plot for continuous data, age vs F877

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:17.500913 INFO::Creating scatter plot for continuous data, age vs F848

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:17.668215 INFO::Creating scatter plot for continuous data, age vs F809

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:17.847663 INFO::Creating scatter plot for continuous data, age vs F751

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:18.024283 INFO::Creating scatter plot for continuous data, age vs F15

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:18.201755 INFO::Creating scatter plot for continuous data, age vs F521

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:18.454982 INFO::Creating scatter plot for continuous data, age vs F842

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:18.644738 INFO::Creating scatter plot for continuous data, age vs F319

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:18.836881 INFO::Creating scatter plot for continuous data, age vs F96

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:19.020774 INFO::Creating scatter plot for continuous data, age vs F171

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:19.203895 INFO::Creating scatter plot for continuous data, age vs F241

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:19.403569 INFO::Creating scatter plot for continuous data, age vs F582

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:19.588738 INFO::Creating scatter plot for continuous data, age vs F822

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:19.769735 INFO::Creating scatter plot for continuous data, age vs F748

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:19.971915 INFO::Creating scatter plot for continuous data, age vs F147

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:20.144954 INFO::Creating scatter plot for continuous data, age vs F16

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:20.34388 INFO::Creating scatter plot for continuous data, age vs F212

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:20.519042 INFO::Creating scatter plot for continuous data, age vs F718

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:20.69135 INFO::Creating scatter plot for continuous data, age vs F663

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:20.883318 INFO::Creating scatter plot for continuous data, age vs F690

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:21.068515 INFO::Creating scatter plot for continuous data, age vs F865

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:21.268944 INFO::Creating scatter plot for continuous data, age vs F421

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:21.444949 INFO::Creating scatter plot for continuous data, age vs F110

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:21.626561 INFO::Creating scatter plot for continuous data, age vs F84

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:21.81932 INFO::Creating scatter plot for continuous data, age vs F123

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:22.003653 INFO::Creating scatter plot for continuous data, age vs F566

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:22.194274 INFO::Creating scatter plot for continuous data, age vs F370

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:22.370605 INFO::Creating scatter plot for continuous data, age vs F65

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:22.543554 INFO::Creating scatter plot for continuous data, age vs F263

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:22.73471 INFO::Creating scatter plot for continuous data, age vs F119

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:22.91032 INFO::Creating scatter plot for continuous data, age vs F630

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:23.109759 INFO::Creating scatter plot for continuous data, age vs F711

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:23.293728 INFO::Creating scatter plot for continuous data, age vs F628

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:23.465477 INFO::Creating scatter plot for continuous data, age vs F152

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:23.65978 INFO::Creating scatter plot for continuous data, age vs F699

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:23.834637 INFO::Creating scatter plot for continuous data, age vs F324

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:24.036237 INFO::Creating scatter plot for continuous data, age vs F575

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:24.223694 INFO::Creating scatter plot for continuous data, age vs F857

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:24.415616 INFO::Creating scatter plot for continuous data, age vs F380

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:24.601471 INFO::Creating scatter plot for continuous data, age vs F504

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:24.784185 INFO::Creating scatter plot for continuous data, age vs F172

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:24.975559 INFO::Creating scatter plot for continuous data, age vs F34

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:25.159034 INFO::Creating scatter plot for continuous data, age vs F199

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:25.349533 INFO::Creating scatter plot for continuous data, age vs F198

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:25.525316 INFO::Creating scatter plot for continuous data, age vs F479

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:25.69853 INFO::Creating scatter plot for continuous data, age vs F673

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:25.89383 INFO::Creating scatter plot for continuous data, age vs F508

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:26.078573 INFO::Creating scatter plot for continuous data, age vs F337

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:26.28066 INFO::Creating scatter plot for continuous data, age vs F737

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:26.466414 INFO::Creating scatter plot for continuous data, age vs F609

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:26.657249 INFO::Creating scatter plot for continuous data, age vs F40

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:26.834761 INFO::Creating scatter plot for continuous data, age vs F821

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:27.019682 INFO::Creating scatter plot for continuous data, age vs F643

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:27.212459 INFO::Creating scatter plot for continuous data, age vs F759

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:27.387878 INFO::Creating scatter plot for continuous data, age vs F417

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:27.592329 INFO::Creating scatter plot for continuous data, age vs F58

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:27.777684 INFO::Creating scatter plot for continuous data, age vs F267

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:28.032173 INFO::Creating scatter plot for continuous data, age vs F101

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:28.221252 INFO::Creating scatter plot for continuous data, age vs F890

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:28.402981 INFO::Creating scatter plot for continuous data, age vs F655

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:28.618369 INFO::Creating scatter plot for continuous data, age vs F95

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:28.807096 INFO::Creating scatter plot for continuous data, age vs F775

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:29.013799 INFO::Creating scatter plot for continuous data, age vs F93

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:29.209846 INFO::Creating scatter plot for continuous data, age vs F353

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:29.389807 INFO::Creating scatter plot for continuous data, age vs F567

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:29.613622 INFO::Creating scatter plot for continuous data, age vs F480

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:29.804157 INFO::Creating scatter plot for continuous data, age vs F295

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:30.010117 INFO::Creating scatter plot for continuous data, age vs F459

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:30.19964 INFO::Creating scatter plot for continuous data, age vs F812

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:30.389338 INFO::Creating scatter plot for continuous data, age vs F146

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:30.591507 INFO::Creating scatter plot for continuous data, age vs F239

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:30.7801 INFO::Creating scatter plot for continuous data, age vs F443

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:30.970521 INFO::Creating scatter plot for continuous data, age vs F871

## `geom_smooth()` using formula = 'y ~ x'

## 2026-05-31 06:41:31.164374 INFO::Creating scatter plot for continuous data, age vs F5

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:31.356469 INFO::Creating scatter plot for continuous data, age vs F715

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:31.569231 INFO::Creating scatter plot for continuous data, age vs F864

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:31.757233 INFO::Creating scatter plot for continuous data, age vs F477

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:31.964613 INFO::Creating scatter plot for continuous data, age vs F571

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## 2026-05-31 06:41:32.162005 INFO::Creating scatter plot for continuous data, age vs F393

## `geom_smooth()` using formula = 'y ~ x'

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

## Initiating effect size calculations
## Calculating mean abundance in: IBD
## Calculating mean abundance in: Control
## Calculating effect size in: IBD
## Initiating prioritization
## Calculating meta-rank and prioritizing metabolic features

## 2026-05-31 06:41:34.203867 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2026-05-31 06:41:34.20929 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2026-05-31 06:41:34.222525 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv

Using dataframes as inputs

abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames 
taxonomy_df = read.csv(file = mets_taxonomy)

# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df)

Running Macarron as individual functions

The Macarron::Macarron() function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:

# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
                       input_annotations = annotations_df,
                       input_metadata = metadata_df)

# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)

# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]

# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
                    mod.assn = prism_modules)

# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules)

# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
                   mac.qval = prism_qval)

# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
                                mod.assn = prism_modules,
                                mac.ava = prism_ava,
                                mac.qval = prism_qval,
                                mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]

# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)

Session info from running the demo in R can be displayed with the following command.

sessionInfo()

## R version 4.6.0 (2026-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: Etc/UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats4    stats     graphics  grDevices utils     datasets  methods  
## [8] base     
## 
## other attached packages:
##  [1] Macarron_1.16.0             SummarizedExperiment_1.42.0
##  [3] Biobase_2.72.0              GenomicRanges_1.64.0       
##  [5] Seqinfo_1.2.0               IRanges_2.46.0             
##  [7] S4Vectors_0.50.1            BiocGenerics_0.58.1        
##  [9] generics_0.1.4              MatrixGenerics_1.24.0      
## [11] matrixStats_1.5.0           BiocStyle_2.40.0           
## 
## loaded via a namespace (and not attached):
##  [1] mnormt_2.1.2          DBI_1.3.0             pbapply_1.7-4        
##  [4] gridExtra_2.3         rlang_1.2.0           magrittr_2.0.5       
##  [7] compiler_4.6.0        mgcv_1.9-4            vctrs_0.7.3          
## [10] stringr_1.6.0         pkgconfig_2.0.3       crayon_1.5.3         
## [13] fastmap_1.2.0         backports_1.5.1       XVector_0.52.0       
## [16] labeling_0.4.3        rmarkdown_2.31        preprocessCore_1.74.0
## [19] xfun_0.57             cachem_1.1.0          jsonlite_2.0.0       
## [22] DelayedArray_0.38.2   BiocParallel_1.46.0   psych_2.6.5          
## [25] parallel_4.6.0        Maaslin2_1.26.0       cluster_2.1.8.2      
## [28] R6_2.6.1              biglm_0.9-3           bslib_0.11.0         
## [31] stringi_1.8.7         RColorBrewer_1.1-3    rpart_4.1.27         
## [34] jquerylib_0.1.4       Rcpp_1.1.1-1.1        iterators_1.0.14     
## [37] knitr_1.51            WGCNA_1.74            base64enc_0.1-6      
## [40] Matrix_1.7-5          splines_4.6.0         nnet_7.3-20          
## [43] tidyselect_1.2.1      rstudioapi_0.18.0     abind_1.4-8          
## [46] yaml_2.3.12           doParallel_1.0.17     codetools_0.2-20     
## [49] plyr_1.8.9            lattice_0.22-9        tibble_3.3.1         
## [52] withr_3.0.2           S7_0.2.2              evaluate_1.0.5       
## [55] foreign_0.8-91        survival_3.8-6        pillar_1.11.1        
## [58] BiocManager_1.30.27   checkmate_2.3.4       foreach_1.5.2        
## [61] pcaPP_2.0-5           ggplot2_4.0.3         scales_1.4.0         
## [64] glue_1.8.1            Hmisc_5.2-5           maketools_1.3.2      
## [67] tools_4.6.0           robustbase_0.99-7     sys_3.4.3            
## [70] data.table_1.18.4     buildtools_1.0.0      mvtnorm_1.4-0        
## [73] fastcluster_1.3.0     grid_4.6.0            impute_1.86.0        
## [76] optparse_1.8.2        colorspace_2.1-2      nlme_3.1-169         
## [79] htmlTable_2.5.0       Formula_1.2-5         cli_3.6.6            
## [82] S4Arrays_1.12.0       dplyr_1.2.1           gtable_0.3.6         
## [85] DEoptimR_1.1-4        logging_0.10-111      dynamicTreeCut_1.63-1
## [88] hash_2.2.6.4          sass_0.4.10           digest_0.6.39        
## [91] SparseArray_1.12.2    htmlwidgets_1.6.4     farver_2.1.2         
## [94] htmltools_0.5.9       lifecycle_1.0.5

Advanced Topics

Generating the input chemical taxonomy file

The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID(). This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.

prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
annotations_df <- read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
taxonomy_df <- decorateID(input_annotations = annotations_df)

Accessory output files

Macarron.log

A record of all chosen parameters and steps that were followed during execution.

modules_measures_of_success.csv

This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:

Total modules: Number of modules.
Singletons: Number of metabolic features that were not assigned to any module at MMS.
% Annotated modules: Percentage of modules that contained at least one annotated metabolic feature.
% Consistent assignments: Percentage of times the same metabolic feature was assigned to the same module e.g. if three metabolic features represent glucose, they should all be in the same module. This percentage must be high.
Max classes per module: The highest number of chemical classes observed in any module. This is evaluated using the chemical taxonomy of covarying annotated features.
90p classes per module: 90th percentile of classes per module; captures the chemical homogeneity of the modules.
Max subclasses per module: The highest number of chemical subclasses observed in any module.
90p subclasses per module: 90th percentile of subclasses per module; captures the chemical homogeneity of the modules.
% Features in HAM: Macarron first finds homogeneously annoted modules (HAMs): These are modules in which >75% annotated features have the same chemical class indicating that they are chemically homogeneous. It then calculates how many features the HAMs account for.

Maaslin2 results

This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.

Changing defaults

Filtering metabolic features based on prevalence

Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence argument.

prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
                                        input_annotations = annotations_df,
                                        input_metadata = metadata_df,
                                        input_taxonomy = taxonomy_df,
                                        min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
                      min_prevalence = 0.5)

Minimum module size

By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA and dynamicTreeCut.

# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)

# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
                            w = prism_w,
                            input_taxonomy = taxonomy_df,
                            min_module_size = 10)

Specifying fixed effects, random effects and reference

Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories. Defaults can be changed with the arguments fixed_effects, random_effects and reference. In the demo example, fixed effects and reference can be defined as follows:

prism_qval <- calQval(se = prism_mbx,
                      mod.assn = prism_modules,
                      metadata_variable = "diagnosis",
                      fixed_effects = c("diagnosis","age","antibiotics"),
                      reference = c("diagnosis,Control";"antibiotics,No"))

Command line invocation

The package source contains a script MacarronCMD.R in inst/scripts to invoke Macarron in the command line using Rscript. The inst/scripts folder also contains a README file that comprehensively documents the usage of the script.

Macarron User Manual