Package: ModCon 1.20.0

Johannes Ptok

ModCon: Modifying splice site usage by changing the mRNP code, while maintaining the genetic code

Collection of functions to calculate a nucleotide sequence surrounding for splice donors sites to either activate or repress donor usage. The proposed alternative nucleotide sequence encodes the same amino acid and could be applied e.g. in reporter systems to silence or activate cryptic splice donor sites.

Authors:Johannes Ptok [aut, cre]

ModCon_1.20.0.tar.gz
ModCon_1.20.0.zip(r-4.7)ModCon_1.20.0.zip(r-4.6)ModCon_1.20.0.zip(r-4.5)
ModCon_1.20.0.tgz(r-4.6-any)ModCon_1.20.0.tgz(r-4.5-any)
ModCon_1.20.0.tar.gz(r-4.7-any)ModCon_1.20.0.tar.gz(r-4.6-any)
ModCon_1.20.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html
card.svg |card.png
ModCon/json (API)
NEWS

# Install 'ModCon' in R:
install.packages('ModCon', repos = c('https://bioc-release.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/caggtaagtat/modcon/issues

Datasets:
  • cds - CDS of firefly luciferase
  • Codons - Table of codons and encoded amino acids
  • hbg - Donor sequences and their HBS
  • hex - Hexamers and Z scores

On BioConductor:ModCon-1.21.0(bioc 3.24)ModCon-1.20.0(bioc 3.23)

functionalgenomicsalternativesplicing

4.00 score 1 stars 8 scripts 298 downloads 21 exports 1 dependencies

Last updated from:01aa217211 (on RELEASE_3_23). Checks:1 WARNING, 9 OK. Indexed: no.

TargetResultTimeFilesSyslog
bioc-checksWARNING153
linux-devel-x86_64OK332
source / vignettesOK245
linux-release-x86_64OK268
macos-release-arm64OK159
macos-oldrel-arm64OK177
windows-develOK305
windows-releaseOK257
windows-oldrelOK271
wasm-releaseOK113

Exports:calculateHZEIintcalculateMaxEntScanScorechangeSequenceHZEICodonscreateCodonMatrixcreateFilialSequencePopulationdecreaseGTsiteStrengthdegradeSAsdegradeSDsgenerateRandomCodonsPerAAgetOverlappingVectorsFromVectorhbghexincreaseGTsiteStrengthModConmutatePopulationrecombineTwoSequencesselectBestAndMeanselectMatingIndividualsslidingWindowHZEImanipulationstartModConApp

Dependencies:data.table

Designing SD context with ModCon

Rendered fromModCon.Rmdusingknitr::rmarkdownon May 29 2026.

Last update: 2021-01-19
Started: 2020-10-21