# --------------------------------------------
# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
# --------------------------------------------
 
cff-version: 1.2.0
message: 'To cite package "RTNsurvival" in publications use:'
type: software
license: Artistic-2.0
title: 'RTNsurvival: Survival analysis using transcriptional networks inferred by
  the RTN package'
version: 1.36.0
doi: 10.1093/bioinformatics/btz229
identifiers:
- type: doi
  value: 10.32614/CRAN.package.RTNsurvival
abstract: 'RTNsurvival integrates regulons inferred by the RTN package with survival
  data. For each regulon, a two-tailed GSEA framework computes a differential Enrichment
  Score (dES) at the individual-sample level. The resulting dES distribution across
  samples is then used to evaluate survival associations within the cohort. Two primary
  workflows are supported: (i) Cox proportional hazards models, in which regulon activities
  are treated as predictors of survival time, and (ii) Kaplan–Meier analyses assessing
  cohort stratification based on regulon activity. All graphical outputs are customizable
  according to user specifications.'
authors:
- family-names: Castro
  given-names: Mauro A. A.
  email: clari.groeneveld@gmail.com
- family-names: Groeneveld
  given-names: Clarice S.
- family-names: Chagas
  given-names: Vinicius S.
preferred-citation:
  type: article
  title: 'RTNsurvival: an R/Bioconductor package for regulatory network survival analysis.'
  authors:
  - family-names: Groeneveld
    given-names: Clarice
  - family-names: Chagas
    given-names: Vinicius
  - family-names: Jones
    given-names: Steven
  - family-names: Robertson
    given-names: Gordon
  - family-names: Ponder
    given-names: Bruce
  - family-names: Meyer
    given-names: Kerstin
  - family-names: Castro
    given-names: Mauro
  journal: Bioinformatics
  year: '2019'
  doi: 10.1093/bioinformatics/btz229
  start: btz229
repository: https://bioc-release.r-universe.dev
commit: cf201916c38c03febb2e15560930edf79c095db3
date-released: '2026-04-28'
contact:
- family-names: Castro
  given-names: Mauro A. A.
  email: clari.groeneveld@gmail.com
references:
- type: article
  title: Regulators of genetic risk of breast cancer identified by integrative network
    analysis.
  authors:
  - family-names: Castro
    given-names: Mauro
  - family-names: Santiago
    given-names: Ines
    name-particle: de
  - family-names: Campbell
    given-names: Thomas
  - family-names: Vaughn
    given-names: Courtney
  - family-names: Hickey
    given-names: Theresa
  - family-names: Ross
    given-names: Edith
  - family-names: Tilley
    given-names: Wayne
  - family-names: Markowetz
    given-names: Florian
  - family-names: Ponder
    given-names: Bruce
  - family-names: Meyer
    given-names: Kerstin
  journal: Nature Genetics
  year: '2016'
  volume: '48'
  doi: 10.1038/ng.3458
  start: '33'