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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "SplineDV" in publications use:'
type: software
license: GPL-2.0-only
title: 'SplineDV: Differential Variability (DV) analysis for single-cell RNA sequencing
  data. (e.g. Identify Differentially Variable Genes across two experimental conditions)'
version: 1.4.0
doi: 10.1038/s41540-025-00507-z
identifiers:
- type: doi
  value: 10.32614/CRAN.package.SplineDV
abstract: 'A spline based scRNA-seq method for identifying differentially variable
  (DV) genes across two experimental conditions. Spline-DV constructs a 3D spline
  from 3 key gene statistics: mean expression, coefficient of variance, and dropout
  rate. This is done for both conditions. The 3D spline provides the “expected” behavior
  of genes in each condition. The distance of the observed mean, CV and dropout rate
  of each gene from the expected 3D spline is used to measure variability. As the
  final step, the spline-DV method compares the variabilities of each condition to
  identify differentially variable (DV) genes.'
authors:
- family-names: Gupta
  given-names: Shreyan
  email: xenon8778@tamu.edu
  orcid: https://orcid.org/0000-0002-1904-9862
- family-names: Cai
  given-names: James
  orcid: https://orcid.org/0000-0002-8081-6725
preferred-citation:
  type: article
  title: Exploring cell-to-cell variability and functional insights through differentially
    variable gene analysis
  authors:
  - family-names: Gatlin
    given-names: Victoria
  - family-names: Gupta
    given-names: Shreyan
    email: xenon8778@tamu.edu
    orcid: https://orcid.org/0000-0002-1904-9862
  - family-names: Romero
    given-names: Selim
  - family-names: Chapkin
    given-names: Robert
  - family-names: Cai
    given-names: James
    orcid: https://orcid.org/0000-0002-8081-6725
  journal: npj systems biology and applications
  year: '2025'
  doi: 10.1038/s41540-025-00507-z
repository: https://bioc-release.r-universe.dev
repository-code: https://github.com/Xenon8778/SplineDV
commit: 92706f0292707cb8c165e12b812711eb182c3d78
url: https://github.com/Xenon8778/SplineDV
date-released: '2026-04-28'
contact:
- family-names: Gupta
  given-names: Shreyan
  email: xenon8778@tamu.edu
  orcid: https://orcid.org/0000-0002-1904-9862