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  "Title": "Detection of cell-type-specific risk-CpG sites in epigenome-wide\nassociation studies",
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  "Author": "Xiangyu Luo <xyluo1991@gmail.com>, Can Yang <macyang@ust.hk>,\nYingying Wei <yweicuhk@gmail.com>",
  "Maintainer": "Xiangyu Luo <xyluo1991@gmail.com>",
  "Description": "In epigenome-wide association studies, the measured\nsignals for each sample are a mixture of methylation profiles\nfrom different cell types. The current approaches to the\nassociation detection only claim whether a\ncytosine-phosphate-guanine (CpG) site is associated with the\nphenotype or not, but they cannot determine the cell type in\nwhich the risk-CpG site is affected by the phenotype. We\npropose a solid statistical method, HIgh REsolution (HIRE),\nwhich not only substantially improves the power of association\ndetection at the aggregated level as compared to the existing\nmethods but also enables the detection of risk-CpG sites for\nindividual cell types. The \"HIREewas\" R package is to implement\nHIRE model in R.",
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