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  "Title": "Integrate TWAS and Colocalization Analysis for Gene Set\nEnrichment Analysis",
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  "Description": "This package integrates colocalization probabilities from\ncolocalization analysis with transcriptome-wide association\nstudy (TWAS) scan summary statistics to implicate genes that\nmay be biologically relevant to a complex trait. The\nprobabilistic framework implemented in this package constrains\nthe TWAS scan z-score-based likelihood using a gene-level\ncolocalization probability. Given gene set annotations, this\npackage can estimate gene set enrichment using posterior\nprobabilities from the TWAS-colocalization integration step.",
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  "Author": "Jeffrey Okamoto [aut, cre] (ORCID:\n<https://orcid.org/0000-0001-9988-1618>),\nXiaoquan Wen [aut] (ORCID: <https://orcid.org/0000-0001-8990-2737>)",
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      "page": "dot-bf_em_coloc_pi0",
      "title": "Multi-INTACT EM algorithm fixed-point function.",
      "topics": [
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    },
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      "page": "dot-bf_loglik_coloc",
      "title": "Multi-INTACT EM algorithm log-likelihood function.",
      "topics": [
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    },
    {
      "page": "dot-bf_weighted_sum_coloc",
      "title": "Helper function for EM algorithm to compute weighted sum of Bayes factors.",
      "topics": [
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    {
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      "topics": [
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      ]
    },
    {
      "page": "dot-enrich_bootstrap_se",
      "title": "Compute bootstrap standard errors for alpha MLEs.",
      "topics": [
        ".enrich_bootstrap_se"
      ]
    },
    {
      "page": "dot-enrich_res",
      "title": "Compute gene set enrichment estimates with standard errors.",
      "topics": [
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    },
    {
      "page": "dot-logistic_em",
      "title": "A fixed-point mapping for the expectation-maximization algorithm. Used as an argument for fixptfn in the squarem function.",
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      "title": "INTACT: Integrate TWAS and Colocalization Analysis for Gene Set Enrichment Analysis",
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        "INTACT-GSE: Gene Set Enrichment Estimation Using INTACT results",
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