{
  "_id": "6a193eb7acfb0bcc41dd5c09",
  "Package": "QDNAseq",
  "Version": "1.48.0",
  "Title": "Quantitative DNA Sequencing for Chromosomal Aberrations",
  "Description": "Quantitative DNA sequencing for chromosomal aberrations.\nThe genome is divided into non-overlapping fixed-sized bins,\nnumber of sequence reads in each counted, adjusted with a\nsimultaneous two-dimensional loess correction for sequence\nmappability and GC content, and filtered to remove spurious\nregions in the genome. Downstream steps of segmentation and\ncalling are also implemented via packages DNAcopy and CGHcall,\nrespectively.",
  "Authors@R": "c(\nperson(\"Ilari\", \"Scheinin\", role=\"aut\"),\nperson(\"Daoud\", \"Sie\", role=c(\"aut\", \"cre\"), email=\"d.sie@vumc.nl\"),\nperson(\"Henrik\", \"Bengtsson\", role=\"aut\"),\nperson(\"Erik\", \"van Dijk\", role=\"ctb\"))",
  "biocViews": "CopyNumberVariation, DNASeq, Genetics, GenomeAnnotation,\nPreprocessing, QualityControl, Sequencing",
  "License": "GPL",
  "URL": "https://github.com/ccagc/QDNAseq",
  "BugReports": "https://github.com/ccagc/QDNAseq/issues",
  "RoxygenNote": "7.3.2",
  "Config/pak/sysreqs": "libbz2-dev liblzma-dev xz-utils zlib1g-dev",
  "Repository": "https://bioc-release.r-universe.dev",
  "Date/Publication": "2026-04-28 12:38:48 UTC",
  "RemoteUrl": "https://github.com/bioc/QDNAseq",
  "RemoteRef": "RELEASE_3_23",
  "RemoteSha": "a403328286782687f575a1633a51de63f8462263",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-29 06:33:46 UTC",
    "User": "root"
  },
  "Author": "Ilari Scheinin [aut],\nDaoud Sie [aut, cre],\nHenrik Bengtsson [aut],\nErik van Dijk [ctb]",
  "Maintainer": "Daoud Sie <d.sie@vumc.nl>",
  "MD5sum": "2ffc552f3c6f2f2c90095f57237a30c1",
  "_user": "bioc-release",
  "_type": "src",
  "_file": "QDNAseq_1.48.0.tar.gz",
  "_fileid": "aa54c08a1715d998ae440350a83bfadd9516a4cc5eba55e5634ede47d6d6b2a0",
  "_filesize": 1322612,
  "_sha256": "aa54c08a1715d998ae440350a83bfadd9516a4cc5eba55e5634ede47d6d6b2a0",
  "_created": "2026-05-29T06:33:46.000Z",
  "_published": "2026-05-29T07:22:30.980Z",
  "_jobs": [
    {
      "job": 78450430514,
      "time": 214,
      "config": "bioc-checks",
      "r": "4.6.0",
      "check": "ERROR",
      "artifact": "7284633809"
    },
    {
      "job": 78450430511,
      "time": 481,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7284694956"
    },
    {
      "job": 78450430499,
      "time": 384,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284671920"
    },
    {
      "job": 78450430494,
      "time": 346,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7285280824"
    },
    {
      "job": 78450430485,
      "time": 284,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7285261915"
    },
    {
      "job": 78449797202,
      "time": 304,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7284583088"
    },
    {
      "job": 78450430495,
      "time": 167,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7284623433"
    },
    {
      "job": 78450430504,
      "time": 482,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7284696990"
    },
    {
      "job": 78450430502,
      "time": 445,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7284686555"
    },
    {
      "job": 78450430498,
      "time": 471,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284692606"
    }
  ],
  "_bioccheck": {
    "error": 1,
    "warning": 4,
    "note": 16
  },
  "_buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/QDNAseq",
  "_commit": {
    "id": "a403328286782687f575a1633a51de63f8462263",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to even y prior to creation of RELEASE_3_23 branch\n",
    "time": 1777379928
  },
  "_maintainer": {
    "name": "Daoud Sie",
    "email": "d.sie@vumc.nl",
    "login": "daoud-sie",
    "description": "",
    "uuid": 4175342
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.1.0",
      "role": "Depends"
    },
    {
      "package": "graphics",
      "role": "Imports"
    },
    {
      "package": "methods",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "BiocGenerics",
      "role": "Imports"
    },
    {
      "package": "Biobase",
      "version": ">= 2.18.0",
      "role": "Imports"
    },
    {
      "package": "CGHbase",
      "version": ">= 1.18.0",
      "role": "Imports"
    },
    {
      "package": "CGHcall",
      "version": ">= 2.18.0",
      "role": "Imports"
    },
    {
      "package": "DNAcopy",
      "version": ">= 1.32.0",
      "role": "Imports"
    },
    {
      "package": "Seqinfo",
      "role": "Imports"
    },
    {
      "package": "GenomicRanges",
      "version": ">= 1.20",
      "role": "Imports"
    },
    {
      "package": "IRanges",
      "version": ">= 2.2",
      "role": "Imports"
    },
    {
      "package": "matrixStats",
      "version": ">= 0.60.0",
      "role": "Imports"
    },
    {
      "package": "R.utils",
      "version": ">= 2.9.0",
      "role": "Imports"
    },
    {
      "package": "Rsamtools",
      "version": ">= 1.20",
      "role": "Imports"
    },
    {
      "package": "future.apply",
      "version": ">= 1.8.1",
      "role": "Imports"
    },
    {
      "package": "BiocStyle",
      "version": ">= 1.8.0",
      "role": "Suggests"
    },
    {
      "package": "BSgenome",
      "version": ">= 1.38.0",
      "role": "Suggests"
    },
    {
      "package": "digest",
      "version": ">= 0.6.20",
      "role": "Suggests"
    },
    {
      "package": "GenomeInfoDb",
      "version": ">= 1.6.0",
      "role": "Suggests"
    },
    {
      "package": "future",
      "version": ">= 1.22.1",
      "role": "Suggests"
    },
    {
      "package": "parallelly",
      "version": ">= 1.28.1",
      "role": "Suggests"
    },
    {
      "package": "R.cache",
      "version": ">= 0.13.0",
      "role": "Suggests"
    },
    {
      "package": "QDNAseq.hg19",
      "role": "Suggests"
    },
    {
      "package": "QDNAseq.mm10",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": false,
  "_usedby": 4,
  "_updates": [
    {
      "week": "2025-31",
      "n": 1
    },
    {
      "week": "2025-44",
      "n": 2
    },
    {
      "week": "2026-18",
      "n": 1
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.49.0",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.48.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "copynumbervariation",
    "dnaseq",
    "genetics",
    "genomeannotation",
    "preprocessing",
    "qualitycontrol",
    "sequencing"
  ],
  "_stars": 54,
  "_contributors": [
    {
      "user": "henrikbengtsson",
      "count": 216,
      "uuid": 1616850
    },
    {
      "user": "daoud-sie",
      "count": 25,
      "uuid": 4175342
    },
    {
      "user": "ilarischeinin",
      "count": 21,
      "uuid": 2540173
    },
    {
      "user": "nturaga",
      "count": 14,
      "uuid": 2746443
    },
    {
      "user": "dtenenba",
      "count": 10,
      "uuid": 2286826
    },
    {
      "user": "jwokaty",
      "count": 8,
      "uuid": 1744257
    },
    {
      "user": "hpages",
      "count": 2,
      "uuid": 8810451
    },
    {
      "user": "vobencha",
      "count": 2,
      "uuid": 2466173
    },
    {
      "user": "roelkluin",
      "count": 1,
      "uuid": 596671
    }
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 962,
    "source": "https://www.bioconductor.org/packages/stats/bioc/QDNAseq"
  },
  "_mentions": 31,
  "_devurl": "https://github.com/ccagc/qdnaseq",
  "_searchresults": 225,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/QDNAseq.html",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/ccagc/qdnaseq",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "addPhenodata",
    "applyFilters",
    "binReadCounts",
    "bpend",
    "bpstart",
    "calculateBlacklist",
    "calculateBlacklistByRegions",
    "calculateMappability",
    "callBins",
    "chromosomes",
    "compareToReference",
    "correctBins",
    "createBins",
    "estimateCorrection",
    "exportBins",
    "frequencyPlot",
    "getBinAnnotations",
    "highlightFilters",
    "isobarPlot",
    "iterateResiduals",
    "makeCgh",
    "noisePlot",
    "normalizeBins",
    "normalizeSegmentedBins",
    "plot",
    "poolRuns",
    "segmentBins",
    "smoothOutlierBins"
  ],
  "_datasets": [
    {
      "name": "LGG150",
      "title": "LGG150 chromosomes 7-10",
      "object": "LGG150",
      "file": "LGG150.rda",
      "class": [
        "QDNAseqReadCounts"
      ],
      "fields": [],
      "table": false,
      "tojson": false
    }
  ],
  "_help": [
    {
      "page": "QDNAseq-package",
      "title": "Package QDNAseq",
      "topics": [
        "QDNAseq-package",
        "QDNAseq"
      ]
    },
    {
      "page": "addPhenodata",
      "title": "Adds phenotype data from a file to a QDNAseqReadCounts or a QDNAseqCopyNumbers object",
      "topics": [
        "addPhenodata"
      ]
    },
    {
      "page": "applyFilters",
      "title": "Adjusts the filtering on which bins are used",
      "topics": [
        "applyFilters",
        "applyFilters,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "binReadCounts",
      "title": "Calculate binned read counts from a set of BAM files",
      "topics": [
        "binReadCounts"
      ]
    },
    {
      "page": "callBins",
      "title": "Call aberrations from segmented copy number data",
      "topics": [
        "callBins",
        "callBins,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "compareToReference",
      "title": "Divide binned read counts with those of reference samples",
      "topics": [
        "compareToReference",
        "compareToReference,QDNAseqCopyNumbers,numeric-method"
      ]
    },
    {
      "page": "correctBins",
      "title": "Correct binned read counts for GC content and mappability",
      "topics": [
        "correctBins",
        "correctBins,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "createBins",
      "title": "Builds bin annotation data for a particular bin size",
      "topics": [
        "calculateBlacklist",
        "calculateBlacklistByRegions",
        "calculateMappability",
        "createBins",
        "iterateResiduals"
      ]
    },
    {
      "page": "estimateCorrection",
      "title": "Estimate correction to read counts for GC content and mappability",
      "topics": [
        "estimateCorrection",
        "estimateCorrection,QDNAseqReadCounts-method"
      ]
    },
    {
      "page": "exportBins",
      "title": "Exports to a file",
      "topics": [
        "exportBins",
        "exportBins,QDNAseqSignals-method"
      ]
    },
    {
      "page": "frequencyPlot",
      "title": "Plot copy number aberration frequencies",
      "topics": [
        "frequencyPlot",
        "frequencyPlot,QDNAseqCopyNumbers,missing-method"
      ]
    },
    {
      "page": "getBinAnnotations",
      "title": "Gets bin annotation data for a particular bin size",
      "topics": [
        "getBinAnnotations"
      ]
    },
    {
      "page": "highlightFilters",
      "title": "Highlights data points in a plotted profile to evaluate filtering",
      "topics": [
        "highlightFilters",
        "highlightFilters,QDNAseqSignals-method"
      ]
    },
    {
      "page": "isobarPlot",
      "title": "Plot median read counts as a function of GC content and mappability",
      "topics": [
        "isobarPlot",
        "isobarPlot,QDNAseqReadCounts,missing-method"
      ]
    },
    {
      "page": "LGG150",
      "title": "LGG150 chromosomes 7-10",
      "topics": [
        "LGG150"
      ]
    },
    {
      "page": "makeCgh",
      "title": "Constructs a 'cghRaw', 'cghSeg', or 'cghCall' object",
      "topics": [
        "makeCgh",
        "makeCgh,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "noisePlot",
      "title": "Plot noise as a function of sequence depth",
      "topics": [
        "noisePlot",
        "noisePlot,QDNAseqReadCounts,missing-method"
      ]
    },
    {
      "page": "normalizeBins",
      "title": "Normalizes binned read counts",
      "topics": [
        "normalizeBins",
        "normalizeBins,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "normalizeSegmentedBins",
      "title": "Normalize segmented bins",
      "topics": [
        "normalizeSegmentedBins",
        "normalizeSegmentedBins,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "plot",
      "title": "Plot copy number profile",
      "topics": [
        "plot",
        "plot,QDNAseqSignals,missing-method"
      ]
    },
    {
      "page": "poolRuns",
      "title": "Pools binned read counts across samples",
      "topics": [
        "poolRuns",
        "poolRuns,QDNAseqSignals,character-method"
      ]
    },
    {
      "page": "QDNAseq-defunct",
      "title": "Defunct functions in package 'QDNAseq'",
      "topics": [
        "downloadBinAnnotations"
      ]
    },
    {
      "page": "QDNAseqCopyNumbers",
      "title": "Container for QDNAseq read count data",
      "topics": [
        "QDNAseqCopyNumbers",
        "QDNAseqCopyNumbers-class"
      ]
    },
    {
      "page": "QDNAseqReadCounts",
      "title": "Container for QDNAseq read count data",
      "topics": [
        "QDNAseqReadCounts",
        "QDNAseqReadCounts-class"
      ]
    },
    {
      "page": "QDNAseqSignals",
      "title": "A parent class for containers of QDNAseq data",
      "topics": [
        "bpend,QDNAseqSignals-method",
        "bpstart,QDNAseqSignals-method",
        "chromosomes,QDNAseqSignals-method",
        "QDNAseqSignals",
        "QDNAseqSignals-class"
      ]
    },
    {
      "page": "segmentBins",
      "title": "Segments normalized copy number data",
      "topics": [
        "segmentBins",
        "segmentBins,QDNAseqCopyNumbers-method"
      ]
    },
    {
      "page": "smoothOutlierBins",
      "title": "Smooth outlier bins after normalization",
      "topics": [
        "smoothOutlierBins",
        "smoothOutlierBins,QDNAseqCopyNumbers-method"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/QDNAseq/raw/RELEASE_3_23/README.md",
  "_rundeps": [
    "BH",
    "Biobase",
    "BiocGenerics",
    "BiocParallel",
    "Biostrings",
    "bitops",
    "CGHbase",
    "CGHcall",
    "codetools",
    "cpp11",
    "crayon",
    "digest",
    "DNAcopy",
    "formatR",
    "futile.logger",
    "futile.options",
    "future",
    "future.apply",
    "generics",
    "GenomicRanges",
    "globals",
    "impute",
    "IRanges",
    "lambda.r",
    "limma",
    "listenv",
    "marray",
    "matrixStats",
    "parallelly",
    "R.methodsS3",
    "R.oo",
    "R.utils",
    "Rhtslib",
    "Rsamtools",
    "S4Vectors",
    "Seqinfo",
    "snow",
    "snowfall",
    "statmod",
    "XVector"
  ],
  "_vignettes": [
    {
      "source": "QDNAseq.Rnw",
      "filename": "QDNAseq.pdf",
      "title": "Introduction to QDNAseq",
      "engine": "utils::Sweave",
      "headings": [],
      "created": "2014-03-20 23:55:49",
      "modified": "2021-10-16 16:57:26",
      "commits": 15
    }
  ],
  "_score": 10.242938770029582,
  "_indexed": false,
  "_nocasepkg": "qdnaseq",
  "_universes": [
    "bioc-release"
  ],
  "_indexurl": "https://bioc.r-universe.dev/QDNAseq",
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.48.0",
      "date": "2026-05-29T06:37:50.000Z",
      "distro": "noble",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "bd51b430aac6eb59f2383d8982eb74bd3b202f56b0ca4cac72fba8a8c14503e9",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.48.0",
      "date": "2026-05-29T06:37:25.000Z",
      "distro": "noble",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "2c894abdad76a03c2be6e71b9b88ed5ef9959e076d36393225436a34874df10c",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.48.0",
      "date": "2026-05-29T07:18:22.000Z",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "91f28189352a39a3a186139d01f672535b484ea00f9fa075bd81680a51296db6",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.48.0",
      "date": "2026-05-29T07:17:49.000Z",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "ee6cbb0177447479c5c7b0d1464e5d5d8405c7e822736bafd0c415028c1b93d7",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "1.48.0",
      "date": "2026-05-29T06:37:01.000Z",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "b108e9cb61d260ae97c6d18327147e6f6c203c86e0f247aff81408e91a736185",
      "status": "success",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.48.0",
      "date": "2026-05-29T06:36:28.000Z",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "3b38ae5b446b7c3457b0303afbc3f72e1216e6348dcd6e8efc54c152983cd490",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.48.0",
      "date": "2026-05-29T06:35:55.000Z",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "b537bb5b2e80bbed6198d5e92d1834976ef0dbc2638c23a3a4c12ff692e4534d",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.48.0",
      "date": "2026-05-29T06:36:06.000Z",
      "commit": "a403328286782687f575a1633a51de63f8462263",
      "fileid": "991bfa37eb4f8c359f546ac34689a3489ef12ea4677a119ae7b9d21353cc6de5",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621959953"
    }
  ]
}