{
  "_id": "6a19394facfb0bcc41dd3ad7",
  "Package": "cellmig",
  "Type": "Package",
  "Title": "Uncertainty-aware quantitative analysis of high-throughput live\ncell migration data",
  "Version": "1.2.0",
  "Authors@R": "c(\nperson(\"Simo\", \"Kitanovski\", email = \"simokitanovski@gmail.com\",\nrole = c(\"aut\", \"cre\"), comment=c(ORCID=\"0000-0003-2909-5376\")))",
  "Description": "High-throughput cell imaging facilitates the analysis of\ncell migration across many wells treated under different\nbiological conditions. These workflows generate considerable\ntechnical noise and biological variability, and therefore\ntechnical and biological replicates are necessary, leading to\nlarge, hierarchically structured datasets, i.e., cells are\nnested within technical replicates that are nested within\nbiological replicates. Current statistical analyses of such\ndata usually ignore the hierarchical structure of the data and\nfail to explicitly quantify uncertainty arising from technical\nor biological variability. To address this gap, we present\ncellmig, an R package implementing Bayesian hierarchical models\nfor migration analysis. cellmig quantifies condition- specific\nvelocity changes (e.g., drug effects) while modeling nested\ndata structures and technical artifacts. It further enables\nsynthetic data generation for experimental design optimization.",
  "License": "GPL-3 + file LICENSE",
  "Encoding": "UTF-8",
  "NeedsCompilation": "yes",
  "biocViews": "SingleCell, CellBiology, Bayesian, ExperimentalDesign,\nSoftware, BatchEffect, Regression, Clustering",
  "BugReports": "https://github.com/snaketron/cellmig/issues",
  "URL": "https://github.com/snaketron/cellmig",
  "RoxygenNote": "7.3.1",
  "VignetteBuilder": "knitr",
  "Biarch": "true",
  "SystemRequirements": "GNU make",
  "Config/pak/sysreqs": "libcairo2-dev cmake libfontconfig1-dev\nlibfreetype6-dev make libicu-dev libpng-dev libuv1-dev",
  "Repository": "https://bioc-release.r-universe.dev",
  "Date/Publication": "2026-04-28 13:05:21 UTC",
  "RemoteUrl": "https://github.com/bioc/cellmig",
  "RemoteRef": "RELEASE_3_23",
  "RemoteSha": "d26eec3088d7a51c77d89372a75d94081a4e535a",
  "Packaged": {
    "Date": "2026-05-29 06:13:09 UTC",
    "User": "root"
  },
  "Author": "Simo Kitanovski [aut, cre] (ORCID:\n<https://orcid.org/0000-0003-2909-5376>)",
  "Maintainer": "Simo Kitanovski <simokitanovski@gmail.com>",
  "MD5sum": "6ee7747cc4aac03744148ce9243a8a28",
  "_user": "bioc-release",
  "_type": "src",
  "_file": "cellmig_1.2.0.tar.gz",
  "_fileid": "ac3f97d54096b01b2b20fe756cb1589b91198664790a2810da9bdd9764451531",
  "_filesize": 5655154,
  "_sha256": "ac3f97d54096b01b2b20fe756cb1589b91198664790a2810da9bdd9764451531",
  "_created": "2026-05-29T06:13:09.000Z",
  "_published": "2026-05-29T06:59:27.076Z",
  "_jobs": [
    {
      "job": 78448187837,
      "time": 265,
      "config": "bioc-checks",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284377588"
    },
    {
      "job": 78448187899,
      "time": 653,
      "config": "linux-devel-arm64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7284466687"
    },
    {
      "job": 78448187984,
      "time": 646,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7284464719"
    },
    {
      "job": 78448187887,
      "time": 674,
      "config": "linux-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284471545"
    },
    {
      "job": 78448187910,
      "time": 669,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284470427"
    },
    {
      "job": 78448187942,
      "time": 343,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7284822785"
    },
    {
      "job": 78448187951,
      "time": 800,
      "config": "macos-oldrel-x86_64",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7284928122"
    },
    {
      "job": 78448187908,
      "time": 335,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284819878"
    },
    {
      "job": 78448187952,
      "time": 870,
      "config": "macos-release-x86_64",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284925687"
    },
    {
      "job": 78446958217,
      "time": 666,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7284315575"
    },
    {
      "job": 78448187885,
      "time": 174,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "FAIL",
      "artifact": ""
    },
    {
      "job": 78448187902,
      "time": 852,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "NOTE",
      "artifact": "7284511824"
    },
    {
      "job": 78448187896,
      "time": 918,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "NOTE",
      "artifact": "7284526885"
    },
    {
      "job": 78448187904,
      "time": 796,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "NOTE",
      "artifact": "7284499335"
    }
  ],
  "_bioccheck": {
    "error": 0,
    "warning": 0,
    "note": 7
  },
  "_buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/bioc/cellmig",
  "_commit": {
    "id": "d26eec3088d7a51c77d89372a75d94081a4e535a",
    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "committer": "A Wokaty <andres.wokaty@sph.cuny.edu>",
    "message": "bump x.y.z version to even y prior to creation of RELEASE_3_23 branch\n",
    "time": 1777381521
  },
  "_maintainer": {
    "name": "Simo Kitanovski",
    "email": "simokitanovski@gmail.com",
    "orcid": "0000-0003-2909-5376"
  },
  "_distro": "noble",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.5.0",
      "role": "Depends"
    },
    {
      "package": "BH",
      "version": ">= 1.66.0",
      "role": "LinkingTo"
    },
    {
      "package": "Rcpp",
      "version": ">= 0.12.0",
      "role": "LinkingTo"
    },
    {
      "package": "RcppEigen",
      "version": ">= 0.3.3.3.0",
      "role": "LinkingTo"
    },
    {
      "package": "RcppParallel",
      "version": ">= 5.0.1",
      "role": "LinkingTo"
    },
    {
      "package": "rstan",
      "version": ">= 2.18.1",
      "role": "LinkingTo"
    },
    {
      "package": "StanHeaders",
      "version": ">= 2.18.0",
      "role": "LinkingTo"
    },
    {
      "package": "base",
      "role": "Imports"
    },
    {
      "package": "ggplot2",
      "role": "Imports"
    },
    {
      "package": "ggforce",
      "role": "Imports"
    },
    {
      "package": "ggtree",
      "role": "Imports"
    },
    {
      "package": "patchwork",
      "role": "Imports"
    },
    {
      "package": "ape",
      "role": "Imports"
    },
    {
      "package": "methods",
      "role": "Imports"
    },
    {
      "package": "Rcpp",
      "version": ">= 0.12.0",
      "role": "Imports"
    },
    {
      "package": "RcppParallel",
      "version": ">= 5.0.1",
      "role": "Imports"
    },
    {
      "package": "reshape2",
      "role": "Imports"
    },
    {
      "package": "rstan",
      "version": ">= 2.18.1",
      "role": "Imports"
    },
    {
      "package": "rstantools",
      "version": ">= 2.4.0",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "scales",
      "role": "Imports"
    },
    {
      "package": "BiocStyle",
      "role": "Suggests"
    },
    {
      "package": "knitr",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "role": "Suggests"
    }
  ],
  "_owner": "bioc",
  "_selfowned": false,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2025-24",
      "n": 4
    },
    {
      "week": "2025-30",
      "n": 3
    },
    {
      "week": "2025-31",
      "n": 2
    },
    {
      "week": "2025-33",
      "n": 14
    },
    {
      "week": "2025-34",
      "n": 14
    },
    {
      "week": "2025-35",
      "n": 2
    },
    {
      "week": "2025-36",
      "n": 3
    },
    {
      "week": "2025-37",
      "n": 5
    },
    {
      "week": "2025-38",
      "n": 1
    },
    {
      "week": "2025-50",
      "n": 1
    },
    {
      "week": "2026-05",
      "n": 4
    },
    {
      "week": "2026-06",
      "n": 2
    },
    {
      "week": "2026-14",
      "n": 3
    },
    {
      "week": "2026-18",
      "n": 1
    }
  ],
  "_tags": [],
  "_bioc": [
    {
      "branch": "devel",
      "version": "1.3.4",
      "bioc": "3.24"
    },
    {
      "branch": "release",
      "version": "1.2.0",
      "bioc": "3.23"
    }
  ],
  "_topics": [
    "singlecell",
    "cellbiology",
    "bayesian",
    "experimentaldesign",
    "software",
    "batcheffect",
    "regression",
    "clustering",
    "cpp"
  ],
  "_stars": 1,
  "_contributors": [
    {
      "user": "snaketron",
      "count": 143,
      "uuid": 5060977
    },
    {
      "user": "jwokaty",
      "count": 4,
      "uuid": 1744257
    }
  ],
  "_userbio": {
    "uuid": 2286807,
    "type": "organization",
    "name": "Bioconductor",
    "description": "Software for the analysis and comprehension of high-throughput genomic data"
  },
  "_downloads": {
    "count": 206,
    "source": "https://www.bioconductor.org/packages/stats/bioc/cellmig"
  },
  "_devurl": "https://github.com/snaketron/cellmig",
  "_searchresults": 14,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/cellmig.html",
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/NEWS.html",
    "extra/NEWS.txt",
    "extra/readme.html",
    "extra/readme.md",
    "manual.pdf"
  ],
  "_homeurl": "https://github.com/snaketron/cellmig",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
    "cellmig",
    "gen_full",
    "gen_partial",
    "get_dose_response_profile",
    "get_groups",
    "get_pairs",
    "get_ppc_means",
    "get_ppc_violins",
    "get_violins"
  ],
  "_datasets": [
    {
      "name": "d",
      "title": "Example dataset 'd'",
      "object": "d",
      "file": "d.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "well",
        "plate",
        "compound",
        "dose",
        "v",
        "offset"
      ],
      "rows": 7560,
      "table": true,
      "tojson": true
    },
    {
      "name": "d_mini",
      "title": "Example dataset 'd'",
      "object": "d_mini",
      "file": "d_mini.RData",
      "class": [
        "data.frame"
      ],
      "fields": [
        "well",
        "plate",
        "compound",
        "dose",
        "v",
        "offset"
      ],
      "rows": 2160,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "cellmig-package",
      "title": "cellmig: quantifying cell migration soeed with hierarchical Bayesian models",
      "topics": [
        "cellmig-package"
      ]
    },
    {
      "page": "cellmig",
      "title": "Model-based quantification of cell migration speed",
      "topics": [
        "cellmig"
      ]
    },
    {
      "page": "d",
      "title": "Example dataset 'd'",
      "topics": [
        "d",
        "d_mini"
      ]
    },
    {
      "page": "sim_full",
      "title": "Simulate data from a fully generative hierarchical Bayesian model",
      "topics": [
        "gen_full"
      ]
    },
    {
      "page": "sim_partial",
      "title": "Simulate data from a partially generative hierarchical Bayesian model",
      "topics": [
        "gen_partial"
      ]
    },
    {
      "page": "get_dose_response_profile",
      "title": "Visualization of dose-response profiles",
      "topics": [
        "get_dose_response_profile"
      ]
    },
    {
      "page": "get_groups",
      "title": "Extract group labels",
      "topics": [
        "get_groups"
      ]
    },
    {
      "page": "get_pairs",
      "title": "Pairwise comparison of treatment effects on cell migration speed",
      "topics": [
        "get_pairs"
      ]
    },
    {
      "page": "ppc_means",
      "title": "Observed vs. predicted cell migration means in each well",
      "topics": [
        "get_ppc_means"
      ]
    },
    {
      "page": "ppc_violin",
      "title": "Posterior Predictive Checks (PPC) Visualization",
      "topics": [
        "get_ppc_violins"
      ]
    },
    {
      "page": "get_violins",
      "title": "Generate violin plots for treatment group comparisons",
      "topics": [
        "get_violins"
      ]
    }
  ],
  "_readme": "https://github.com/bioc/cellmig/raw/RELEASE_3_23/README.md",
  "_rundeps": [
    "abind",
    "ape",
    "aplot",
    "backports",
    "base64enc",
    "BH",
    "bslib",
    "cachem",
    "callr",
    "checkmate",
    "cli",
    "cpp11",
    "desc",
    "digest",
    "distributional",
    "dplyr",
    "evaluate",
    "farver",
    "fastmap",
    "fontawesome",
    "fontBitstreamVera",
    "fontLiberation",
    "fontquiver",
    "fs",
    "gdtools",
    "generics",
    "ggforce",
    "ggfun",
    "ggiraph",
    "ggplot2",
    "ggplotify",
    "ggtree",
    "glue",
    "gridExtra",
    "gridGraphics",
    "gtable",
    "highr",
    "htmltools",
    "htmlwidgets",
    "inline",
    "isoband",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "lattice",
    "lazyeval",
    "lifecycle",
    "loo",
    "magrittr",
    "MASS",
    "matrixStats",
    "memoise",
    "mime",
    "nlme",
    "numDeriv",
    "patchwork",
    "pillar",
    "pkgbuild",
    "pkgconfig",
    "plyr",
    "polyclip",
    "posterior",
    "processx",
    "ps",
    "purrr",
    "QuickJSR",
    "R6",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "RcppEigen",
    "RcppParallel",
    "reshape2",
    "rlang",
    "rmarkdown",
    "rstan",
    "rstantools",
    "S7",
    "sass",
    "scales",
    "StanHeaders",
    "stringi",
    "stringr",
    "systemfonts",
    "tensorA",
    "tibble",
    "tidyr",
    "tidyselect",
    "tidytree",
    "tinytex",
    "treeio",
    "tweenr",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "xfun",
    "yaml",
    "yulab.utils"
  ],
  "_sysdeps": [
    {
      "shlib": "libstdc++",
      "package": "libstdc++6",
      "source": "gcc",
      "version": "14.2.0-4ubuntu2~24.04.1",
      "name": "c++",
      "homepage": "http://gcc.gnu.org/",
      "description": "GNU Standard C++ Library v3"
    }
  ],
  "_vignettes": [
    {
      "source": "User_manual_analysis.Rmd",
      "filename": "User_manual_analysis.html",
      "title": "cellmig: quantifying cell migration speed with hierarchical Bayesian models",
      "author": "Simo Kitanovski (simo.kitanovski@uni-due.de)",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Background",
        "Installation",
        "Data",
        "Visualizing raw cell speed",
        "Mean migration speed per well",
        "cellmig analysis",
        "Model fitting",
        "What are the overall treatment effects ($\\delta_t$) on speed?",
        "Visualizing $\\delta_t$",
        "Dose-response profiles",
        "Pairwise comparisons of treatment effects",
        "Violin plots of pairwise differences",
        "Posterior predictive checks (PPCs)",
        "Compare simulated data to observed data at the cell level",
        "Compare mean velocity per well",
        "Other model parameters",
        "Session Info"
      ],
      "created": "2025-08-12 16:55:40",
      "modified": "2026-01-30 00:04:39",
      "commits": 10
    },
    {
      "source": "User_manual_simulation.Rmd",
      "filename": "User_manual_simulation.html",
      "title": "Simulating data with cellmig",
      "author": "Simo Kitanovski (simo.kitanovski@uni-due.de)",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Background",
        "Data simulation from partially generative model",
        "Model specification",
        "Setting $\\alpha_p$",
        "Defining the control treatment (offset)",
        "Setting $\\kappa_w$",
        "Generates dataframe with simulated speeds",
        "Analyzing simulated data with r Biocpkg(\"cellmig\")",
        "Comparing simulated vs. inferred parameters",
        "Plate-specific offsets ($\\alpha_p$)",
        "Effect sizes ($\\delta_t$)",
        "Biological ($\\sigma_{bio}$) and technical ($\\sigma_{tech}$) variability",
        "Data simulation from fully generative model",
        "Compare density of speeds from partially vs. fully generative models",
        "Power analysis",
        "Session Info"
      ],
      "created": "2025-08-12 16:55:40",
      "modified": "2026-01-27 17:01:43",
      "commits": 8
    }
  ],
  "_score": 5.292256071356476,
  "_indexed": false,
  "_nocasepkg": "cellmig",
  "_universes": [
    "bioc-release"
  ],
  "_indexurl": "https://bioc.r-universe.dev/cellmig",
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.2.0",
      "date": "2026-05-29T06:18:52.000Z",
      "distro": "noble",
      "arch": "aarch64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "0b1f2bde2fa2178521463f8ab1e667de68c86a526c1f796b8df764062c55fa54",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "1.2.0",
      "date": "2026-05-29T06:18:35.000Z",
      "distro": "noble",
      "arch": "x86_64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "40f1d902fcf1fec30c2f2ddc03775f49bd7e3711c379a3849047ca58e607443f",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.2.0",
      "date": "2026-05-29T06:19:08.000Z",
      "distro": "noble",
      "arch": "aarch64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "2551299a18d5825c6b7e8a59fa68b9e4433a7eb8fb0c31b77977b4d385cf2056",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "1.2.0",
      "date": "2026-05-29T06:19:01.000Z",
      "distro": "noble",
      "arch": "x86_64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "13cce2cde8a1b39240f1745cdd3d8587f2a67c65d0efd075c6fb90628d2f6664",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.2.0",
      "date": "2026-05-29T06:46:57.000Z",
      "arch": "aarch64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "a6658475bd2c222139bc3b1997e3a2388e2547805bc2c71449ace640c3311383",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "1.2.0",
      "date": "2026-05-29T06:48:29.000Z",
      "arch": "x86_64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "cfb996dccc8ae853549e675369271b41dcced1e2c28ee07da2ba849eca9e173d",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.2.0",
      "date": "2026-05-29T06:47:02.000Z",
      "arch": "aarch64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "0d9f9bb7677c29a987238151f66efaa053ce55316bb83c7b980f463646e5fd00",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "1.2.0",
      "date": "2026-05-29T06:48:19.000Z",
      "arch": "x86_64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "610a8ddd6ece466b287e9665d655d9136ae3739cab5f370b4c20b0446bdd5803",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "1.2.0",
      "date": "2026-05-29T06:16:55.000Z",
      "arch": "x86_64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "01e120aa4efa9e173be80163619f584f7874f750470190af97980ad802313cde",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "1.2.0",
      "date": "2026-05-29T06:16:49.000Z",
      "arch": "x86_64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "793d5084fb89208be564df6d40c09d83f62d158fd76087ad8c7a3965d44c412c",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "1.2.0",
      "date": "2026-05-29T06:16:29.000Z",
      "arch": "x86_64",
      "commit": "d26eec3088d7a51c77d89372a75d94081a4e535a",
      "fileid": "1256c502ab5ea5d7866729dd5764478e80e014e40eea78316977135b9c00956b",
      "status": "success",
      "check": "NOTE",
      "buildurl": "https://github.com/r-universe/bioc-release/actions/runs/26621082881"
    }
  ]
}