{ "_id": "6a1bebbf1d7bb097a0a1f6e3", "Package": "crisprScore", "Version": "1.16.0", "Date": "2026-04-02", "Title": "On-Target and Off-Target Scoring Algorithms for CRISPR gRNAs", "Authors@R": "c(\nperson(\"Jean-Philippe\", \"Fortin\", email = \"fortin946@gmail.com\", role = c(\"aut\", \"cre\", \"cph\")),\nperson(\"Aaron\", \"Lun\", email = \"infinite.monkeys.with.keyboards@gmail.com\", role = c(\"aut\")),\nperson(\"Luke\", \"Hoberecht\", email = \"lukehob3@gmail.com\", role = c(\"ctb\")),\nperson(\"Pirunthan\", \"Perampalam\", email = \"pirunthan@gmail.com\", role = c(\"ctb\")))", "biocViews": "CRISPR, FunctionalGenomics, FunctionalPrediction", "Description": "Provides R wrappers of several on-target and off-target\nscoring methods for CRISPR guide RNAs (gRNAs). The following\nnucleases are supported: SpCas9, AsCas12a, enAsCas12a, and\nRfxCas13d (CasRx). The available on-target cutting efficiency\nscoring methods are RuleSet1, RuleSet3, DeepHF, enPAM+GB, and\nCRISPRscan. Both the CFD and MIT scoring methods are available\nfor off-target specificity prediction. The package also\nprovides a Lindel-derived score to predict the probability of a\ngRNA to produce indels inducing a frameshift for the Cas9\nnuclease. Note that DeepHF and enPAM+GB are not available on\nWindows machines.", "License": "MIT + file LICENSE", "Encoding": "UTF-8", "RoxygenNote": "7.3.3", "VignetteBuilder": "knitr", "StagedInstall": "no", "BugReports": "https://github.com/crisprVerse/crisprScore", "URL": "https://github.com/crisprVerse/crisprScore/issues", "LazyData": "true", "Config/pak/sysreqs": "libicu-dev libpng-dev libssl-dev python3 zlib1g-dev", "Repository": "https://bioc-release.r-universe.dev", "Date/Publication": "2026-04-28 12:57:38 UTC", "RemoteUrl": "https://github.com/bioc/crisprScore", "RemoteRef": "RELEASE_3_23", "RemoteSha": "81c327cfaea687852c3bf7a5c83503c1906a43f6", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-31 06:47:28 UTC", "User": "root" }, "Author": "Jean-Philippe Fortin [aut, cre, cph],\nAaron Lun [aut],\nLuke Hoberecht [ctb],\nPirunthan Perampalam [ctb]", "Maintainer": "Jean-Philippe Fortin ", "MD5sum": "dffbe63e6e6de7959df1f8b783ddbb30", "_user": "bioc-release", "_type": "src", 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