{
  "_id": "6a2126cbcd65a98ecbd21327",
  "Package": "sarks",
  "Title": "Suffix Array Kernel Smoothing for discovery of correlative\nsequence motifs and multi-motif domains",
  "Version": "1.24.0",
  "Authors@R": "person(given = \"Dennis\",\nfamily = \"Wylie\",\nrole = c(\"aut\", \"cre\"),\nemail = \"denniscwylie@gmail.com\",\ncomment = c(ORCID = \"0000-0003-0380-3549\"))",
  "Description": "Suffix Array Kernel Smoothing (see\nhttps://academic.oup.com/bioinformatics/article-abstract/35/20/3944/5418797),\nor SArKS, identifies sequence motifs whose presence correlates\nwith numeric scores (such as differential expression\nstatistics) assigned to the sequences (such as gene promoters).\nSArKS smooths over sequence similarity, quantified by location\nwithin a suffix array based on the full set of input sequences.\nA second round of smoothing over spatial proximity within\nsequences reveals multi-motif domains. Discovered motifs can\nthen be merged or extended based on adjacency within MMDs.\nFalse positive rates are estimated and controlled by\npermutation testing.",
  "biocViews": "MotifDiscovery, GeneRegulation, GeneExpression,\nTranscriptomics, RNASeq, DifferentialExpression,\nFeatureExtraction",
  "SystemRequirements": "Java (>= 1.8)",
  "License": "BSD_3_clause + file LICENSE",
  "Encoding": "UTF-8",
  "LazyData": "false",
  "RoxygenNote": "6.1.1",
  "BugReports": "https://github.com/denniscwylie/sarks/issues",
  "URL": "https://academic.oup.com/bioinformatics/article-abstract/35/20/3944/5418797,\nhttps://github.com/denniscwylie/sarks",
  "Config/pak/sysreqs": "make default-jdk zlib1g-dev",
  "Repository": "https://bioc-release.r-universe.dev",
  "Date/Publication": "2026-04-28 12:52:02 UTC",
  "RemoteUrl": "https://github.com/bioc/sarks",
  "RemoteRef": "RELEASE_3_23",
  "RemoteSha": "4d1c1c7160ba13fc6951e4db1451ae46569e69a9",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-04 07:13:59 UTC",
    "User": "root"
  },
  "Author": "Dennis Wylie [aut, cre] (ORCID:\n<https://orcid.org/0000-0003-0380-3549>)",
  "Maintainer": "Dennis Wylie <denniscwylie@gmail.com>",
  "MD5sum": "6845e3eca1a0faaf85b193727c4b9b10",
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  "_created": "2026-06-04T07:13:59.000Z",
  "_published": "2026-06-04T07:18:35.373Z",
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    "author": "A Wokaty <andres.wokaty@sph.cuny.edu>",
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    "message": "bump x.y.z version to even y prior to creation of RELEASE_3_23 branch\n",
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    },
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    },
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    },
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    },
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      "package": "RUnit",
      "role": "Suggests"
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    },
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  "_topics": [
    "motifdiscovery",
    "generegulation",
    "geneexpression",
    "transcriptomics",
    "rnaseq",
    "differentialexpression",
    "featureextraction",
    "openjdk"
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    "type": "organization",
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    "description": "Software for the analysis and comprehension of high-throughput genomic data"
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  "_devurl": "https://github.com/denniscwylie/sarks",
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  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
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    "extra/contents.json",
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    "extra/NEWS.txt",
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    "extra/readme.md",
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    "manual.pdf"
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  "_homeurl": "https://github.com/denniscwylie/sarks",
  "_realowner": "bioc",
  "_cranurl": false,
  "_exports": [
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    "blockScores",
    "clusterCounts",
    "clusterKmers",
    "estimateFalsePositiveRate",
    "extendKmers",
    "kmerCounts",
    "kmerPeaks",
    "locateClusters",
    "locateKmers",
    "mergedKmerSubPeaks",
    "permutationDistribution",
    "permutationThresholds",
    "pruneIntervals",
    "regexCounts",
    "regexLocate",
    "Sarks",
    "sarksFilters",
    "sourceBlock"
  ],
  "_datasets": [
    {
      "name": "simulatedScores",
      "title": "Scores associated with simulated sequences from SArKS paper.",
      "object": "simulatedScores",
      "file": "simulatedScores.rda",
      "class": [
        "integer"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "simulatedSeqs",
      "title": "Simulated sequences from SArKS paper.",
      "object": "simulatedSeqs",
      "file": "simulatedSeqs.rda",
      "class": [
        "character"
      ],
      "fields": [],
      "table": false,
      "tojson": true
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  "_help": [
    {
      "page": "blockInfo",
      "title": "Get sarks smoothed scores for input sequence",
      "topics": [
        "blockInfo"
      ]
    },
    {
      "page": "blockScores",
      "title": "SArKS input scores",
      "topics": [
        "blockScores"
      ]
    },
    {
      "page": "clusterCounts",
      "title": "Count occurrences of k-mer clusters",
      "topics": [
        "clusterCounts"
      ]
    },
    {
      "page": "clusterKmers",
      "title": "Cluster k-mers",
      "topics": [
        "clusterKmers"
      ]
    },
    {
      "page": "estimateFalsePositiveRate",
      "title": "Estimating SArKS false positive rate",
      "topics": [
        "estimateFalsePositiveRate"
      ]
    },
    {
      "page": "extendKmers",
      "title": "Extend k-mers in length where possible",
      "topics": [
        "extendKmers"
      ]
    },
    {
      "page": "kmerCounts",
      "title": "Count occurrences of k-mer",
      "topics": [
        "kmerCounts"
      ]
    },
    {
      "page": "kmerPeaks",
      "title": "Call k-mer peaks",
      "topics": [
        "kmerPeaks"
      ]
    },
    {
      "page": "locateClusters",
      "title": "Locate occurrences of specified clusters of k-mers",
      "topics": [
        "locateClusters"
      ]
    },
    {
      "page": "locateKmers",
      "title": "Locate occurrences of specified k-mers",
      "topics": [
        "locateKmers"
      ]
    },
    {
      "page": "mergedKmerSubPeaks",
      "title": "Identify and merge k-mer sub-peaks within multi-motif domains",
      "topics": [
        "mergedKmerSubPeaks"
      ]
    },
    {
      "page": "permutationDistribution",
      "title": "Estimating distribution of maximum smoothed sequence scores under permutation",
      "topics": [
        "permutationDistribution"
      ]
    },
    {
      "page": "permutationThresholds",
      "title": "Set smoothed score thresholds based on permutation distribution",
      "topics": [
        "permutationThresholds"
      ]
    },
    {
      "page": "pruneIntervals",
      "title": "Prune nested k-mer intervals from called k-mer peak set.",
      "topics": [
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      ]
    },
    {
      "page": "regexCounts",
      "title": "Count occurrences of regular expression",
      "topics": [
        "regexCounts"
      ]
    },
    {
      "page": "regexLocate",
      "title": "Locate occurrences of regular expression",
      "topics": [
        "regexLocate"
      ]
    },
    {
      "page": "Sarks",
      "title": "Suffix Array Kernel Smoothing",
      "topics": [
        "Sarks"
      ]
    },
    {
      "page": "sarksFilters",
      "title": "Smoothing window and Gini impurity filter settings",
      "topics": [
        "sarksFilters"
      ]
    },
    {
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      "title": "Scores associated with simulated sequences from SArKS paper.",
      "topics": [
        "simulatedScores"
      ]
    },
    {
      "page": "simulatedSeqs",
      "title": "Simulated sequences from SArKS paper.",
      "topics": [
        "simulatedSeqs"
      ]
    },
    {
      "page": "sourceBlock",
      "title": "Identify associated input sequence for given position(s) in suffix array",
      "topics": [
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