Package: decompTumor2Sig
Type: Package
Title: Decomposition of individual tumors into mutational signatures by
        signature refitting
Depends: R(>= 4.0), ggplot2
Imports: methods, Matrix, quadprog(>= 1.5-5), GenomicRanges, stats,
        GenomicFeatures, Biostrings, BiocGenerics, S4Vectors, plyr,
        utils, graphics, BSgenome.Hsapiens.UCSC.hg19,
        TxDb.Hsapiens.UCSC.hg19.knownGene, VariantAnnotation,
        SummarizedExperiment, ggseqlogo, gridExtra, data.table,
        Seqinfo, readxl
Suggests: knitr, rmarkdown, BiocStyle
Version: 2.28.1
Date: 2026-07-21
Encoding: UTF-8
Authors@R: c(
    person("Rosario M.", "Piro", email = "rmpiro@gmail.com",
            role = c("aut", "cre")),
    person("Sandra", "Krueger", role = c("ctb"))
    )
Description: Uses quadratic programming for signature refitting, i.e.,
        to decompose the mutation catalog from an individual tumor
        sample into a set of given mutational signatures (either
        Alexandrov-model signatures or Shiraishi-model signatures),
        computing weights that reflect the contributions of the
        signatures to the mutation load of the tumor.
License: GPL-2
URL: http://rmpiro.net/decompTumor2Sig/,
        https://github.com/rmpiro/decompTumor2Sig
BugReports: https://github.com/rmpiro/decompTumor2Sig/issues
biocViews: Software, SNP, Sequencing, DNASeq, GenomicVariation,
        SomaticMutation, BiomedicalInformatics, Genetics,
        BiologicalQuestion, StatisticalMethod
VignetteBuilder: knitr
RoxygenNote: 7.1.2
Config/pak/sysreqs: make libbz2-dev liblzma-dev libpng-dev libxml2-dev
        libssl-dev xz-utils zlib1g-dev
Repository: Bioconductor 3.23
Date/Publication: 2026-07-21 16:21:34 UTC
RemoteUrl: https://github.com/bioc/decompTumor2Sig
RemoteRef: RELEASE_3_23
RemoteSha: a438ec11dde8ce0536e5727a9e6d75fb496dd841
NeedsCompilation: no
Packaged: 2026-09-19 09:29:11 UTC; root
Author: Rosario M. Piro [aut, cre],
  Sandra Krueger [ctb]
Maintainer: Rosario M. Piro <rmpiro@gmail.com>