Package: methylSig 1.24.0

Raymond G. Cavalcante

methylSig: MethylSig: Differential Methylation Testing for WGBS and RRBS Data

MethylSig is a package for testing for differentially methylated cytosines (DMCs) or regions (DMRs) in whole-genome bisulfite sequencing (WGBS) or reduced representation bisulfite sequencing (RRBS) experiments. MethylSig uses a beta binomial model to test for significant differences between groups of samples. Several options exist for either site-specific or sliding window tests, and variance estimation.

Authors:Yongseok Park [aut], Raymond G. Cavalcante [aut, cre]

methylSig_1.24.0.tar.gz
methylSig_1.24.0.zip(r-4.7)methylSig_1.24.0.zip(r-4.6)methylSig_1.24.0.zip(r-4.5)
methylSig_1.24.0.tgz(r-4.6-any)methylSig_1.24.0.tgz(r-4.5-any)
methylSig_1.24.0.tar.gz(r-4.7-any)methylSig_1.24.0.tar.gz(r-4.6-any)
methylSig_1.24.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
card.svg |card.png
methylSig/json (API)
NEWS

# Install 'methylSig' in R:
install.packages('methylSig', repos = c('https://bioc-release.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/sartorlab/methylsig/issues

Datasets:

On BioConductor:methylSig-1.25.0(bioc 3.24)methylSig-1.24.0(bioc 3.23)

dnamethylationdifferentialmethylationepigeneticsregressionmethylseqdifferential-methylationdna-methylation

7.94 score 20 stars 36 scripts 344 downloads 11 mentions 9 exports 82 dependencies

Last updated from:8c4a67e0eb (on RELEASE_3_23). Checks:1 NOTE, 9 OK. Indexed: no.

TargetResultTimeFilesSyslog
bioc-checksNOTE269
linux-devel-x86_64OK527
source / vignettesOK343
linux-release-x86_64OK421
macos-release-arm64OK420
macos-oldrel-arm64OK258
windows-develOK501
windows-releaseOK620
windows-oldrelOK405
wasm-releaseOK204

Exports:diff_binomialdiff_dss_fitdiff_dss_testdiff_methylsigfilter_loci_by_coveragefilter_loci_by_group_coveragefilter_loci_by_locationtile_by_regionstile_by_windows

Dependencies:abindaskpassassortheadbeachmatBHBiobaseBiocGenericsBiocIObiocmakeBiocParallelBiostringsbitopsBSgenomebsseqcigarilloclicodetoolscpp11crayoncurldata.tableDelayedArrayDelayedMatrixStatsdir.expiryDSSfarverfilelockformatRfutile.loggerfutile.optionsgenericsGenomicAlignmentsGenomicRangesgluegtoolsh5mreadHDF5ArrayhttrIRangesjsonlitelabelinglambda.rlatticelifecyclelimmalocfitMatrixMatrixGenericsmatrixStatsmimeopensslpermuteR.methodsS3R.ooR.utilsR6RColorBrewerRcppRCurlrestfulrrhdf5rhdf5filtersRhdf5libRhtslibrjsonrlangRsamtoolsrtracklayerS4ArraysS4VectorsscalesSeqinfosnowSparseArraysparseMatrixStatsstatmodSummarizedExperimentsysviridisLiteXMLXVectoryaml

Updating methylSig code

Raymond G. Cavalcante

Rendered fromupdating-methylSig-code.Rmdusingknitr::rmarkdownon May 29 2026.

Last update: 2020-03-23
Started: 2020-03-23

Using methylSig

Yongseok Park, Raymond G. Cavalcante, Maria E. Figueroa, Laura S. Rozek, and Maureen A. Sartor

Rendered fromusing-methylSig.Rmdusingknitr::rmarkdownon May 29 2026.

Last update: 2020-03-23
Started: 2020-03-23