Package: mslp
Type: Package
Title: Predict synthetic lethal partners of tumour mutations
Version: 1.14.0
Authors@R: person(given = "Chunxuan", family = "Shao", role = c("aut", "cre"), email = "chunxuan@outlook.com")
Description: An integrated pipeline to predict the potential synthetic
        lethality partners (SLPs) of tumour mutations, based on gene
        expression, mutation profiling and cell line genetic screens
        data. It has builtd-in support for data from cBioPortal. The
        primary SLPs correlating with muations in WT and compensating
        for the loss of function of mutations are predicted by random
        forest based methods (GENIE3) and Rank Products, respectively.
        Genetic screens are employed to identfy consensus SLPs leads to
        reduced cell viability when perturbed.
License: GPL-3
Encoding: UTF-8
LazyData: false
RoxygenNote: 7.2.3
Depends: R (>= 4.2.0)
Imports: data.table (>= 1.13.0), doRNG, fmsb, foreach, magrittr,
        org.Hs.eg.db, pROC, randomForest, RankProd, stats, utils
Suggests: BiocStyle, doFuture, future, knitr, rmarkdown, roxygen2,
        tinytest
VignetteBuilder: knitr
biocViews: Pharmacogenetics, Pharmacogenomics
Config/pak/sysreqs: libgmp3-dev libpng-dev libmpfr-dev libssl-dev
        zlib1g-dev
Repository: Bioconductor 3.23
Date/Publication: 2026-04-28 12:58:37 UTC
RemoteUrl: https://github.com/bioc/mslp
RemoteRef: RELEASE_3_23
RemoteSha: 62aa4eb31de45f86e58d82f38ced8b8e1c43eae7
NeedsCompilation: no
Packaged: 2026-09-19 08:18:03 UTC; root
Author: Chunxuan Shao [aut, cre]
Maintainer: Chunxuan Shao <chunxuan@outlook.com>